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A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 2: results by subsites.
Oral Oncol 2010; 46(10):720-6OO

Abstract

Oral and pharyngeal cancers are strongly related to alcohol drinking. We combined findings from all case-control and cohort studies published up to September 2009 and presented analyses by subsites, using a meta-analytic approach. Summary measures were obtained using random-effects models, and taking into account the correlation between estimates from the same study. We also performed a dose-risk analysis, using a random-effects meta-regression model. Compared to non- or occasional drinkers, the overall relative risks (RR) for light drinkers were 1.17 (95% confidence interval, CI, 1.01-1.35) for oral (nine studies) and 1.23 (95% CI, 0.87-1.73) for pharyngeal (five studies) cancer, with no significant heterogeneity between the two sites (p=0.793). RRs for heavy drinkers were 4.64 (95% CI, 3.78-5.70) for oral (17 studies) and 6.62 (95% CI, 4.72-9.29) for pharyngeal (17 studies) cancer (p of heterogeneity between the two sites=0.075). The summary RRs for heavy drinkers were 4.11 (95% CI, 2.46-6.87) for tongue (five studies), 7.76 (95% CI, 4.77-12.62) for oropharyngeal (four studies), and 9.03 (95% CI, 4.46-18.27) for hypopharyngeal (four studies) cancer. In conclusion, the alcohol-related RRs are higher for pharyngeal than for oral cancer, particularly at higher doses, while the association with cancer of the tongue was similar to that for oral cancer.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche "Mario Negri", Milano, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20728401

Citation

Turati, Federica, et al. "A Meta-analysis of Alcohol Drinking and Oral and Pharyngeal Cancers. Part 2: Results By Subsites." Oral Oncology, vol. 46, no. 10, 2010, pp. 720-6.
Turati F, Garavello W, Tramacere I, et al. A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 2: results by subsites. Oral Oncol. 2010;46(10):720-6.
Turati, F., Garavello, W., Tramacere, I., Bagnardi, V., Rota, M., Scotti, L., ... Negri, E. (2010). A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 2: results by subsites. Oral Oncology, 46(10), pp. 720-6. doi:10.1016/j.oraloncology.2010.07.010.
Turati F, et al. A Meta-analysis of Alcohol Drinking and Oral and Pharyngeal Cancers. Part 2: Results By Subsites. Oral Oncol. 2010;46(10):720-6. PubMed PMID: 20728401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 2: results by subsites. AU - Turati,Federica, AU - Garavello,Werner, AU - Tramacere,Irene, AU - Bagnardi,Vincenzo, AU - Rota,Matteo, AU - Scotti,Lorenza, AU - Islami,Farhad, AU - Corrao,Giovanni, AU - Boffetta,Paolo, AU - La Vecchia,Carlo, AU - Negri,Eva, Y1 - 2010/08/21/ PY - 2010/07/05/received PY - 2010/07/20/revised PY - 2010/07/21/accepted PY - 2010/8/24/entrez PY - 2010/8/24/pubmed PY - 2011/4/22/medline SP - 720 EP - 6 JF - Oral oncology JO - Oral Oncol. VL - 46 IS - 10 N2 - Oral and pharyngeal cancers are strongly related to alcohol drinking. We combined findings from all case-control and cohort studies published up to September 2009 and presented analyses by subsites, using a meta-analytic approach. Summary measures were obtained using random-effects models, and taking into account the correlation between estimates from the same study. We also performed a dose-risk analysis, using a random-effects meta-regression model. Compared to non- or occasional drinkers, the overall relative risks (RR) for light drinkers were 1.17 (95% confidence interval, CI, 1.01-1.35) for oral (nine studies) and 1.23 (95% CI, 0.87-1.73) for pharyngeal (five studies) cancer, with no significant heterogeneity between the two sites (p=0.793). RRs for heavy drinkers were 4.64 (95% CI, 3.78-5.70) for oral (17 studies) and 6.62 (95% CI, 4.72-9.29) for pharyngeal (17 studies) cancer (p of heterogeneity between the two sites=0.075). The summary RRs for heavy drinkers were 4.11 (95% CI, 2.46-6.87) for tongue (five studies), 7.76 (95% CI, 4.77-12.62) for oropharyngeal (four studies), and 9.03 (95% CI, 4.46-18.27) for hypopharyngeal (four studies) cancer. In conclusion, the alcohol-related RRs are higher for pharyngeal than for oral cancer, particularly at higher doses, while the association with cancer of the tongue was similar to that for oral cancer. SN - 1879-0593 UR - https://www.unboundmedicine.com/medline/citation/20728401/A_meta_analysis_of_alcohol_drinking_and_oral_and_pharyngeal_cancers__Part_2:_results_by_subsites_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-8375(10)00226-5 DB - PRIME DP - Unbound Medicine ER -