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Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia.
J Clin Virol. 2010 Oct; 49(2):94-9.JC

Abstract

BACKGROUND

Human rhinoviruses (HRVs) are among the most common causes of community-acquired pneumonia (CAP) in children. However, the differential roles of the three HRV species HRV-A, HRV-B, and HRV-C in pediatric CAP are not fully understood.

OBJECTIVE

To determine the distribution of HRV species and their roles in children hospitalized with CAP in Beijing, China.

STUDY DESIGN

Nasopharyngeal aspirates were collected between April 2007 and March 2008 from 554 children with a primary diagnosis of CAP. HRVs in the clinical samples were detected by RT-PCR and by sequencing. Infections with other respiratory viruses were identified by PCR.

RESULTS

HRVs were detected in 99 patients (17.87%). Among these patients, 51.52% tested positive for HRV-A, 38.38% for HRV-C, and 10.10% for HRV-B. HRVs were detected throughout the study period. The monthly distribution of HRV infections varied with HRV species. Median age, gender, symptoms, severity, and duration of hospitalization for single HRV-C infections were similar to those observed for single HRV-A infections. Co-infections with other respiratory viruses were detected in 57.58% of the HRV-positive children. HRV/RSV dual infections were correlated with a higher frequency of shortness of breath (HRV-A group, P(2 tail)= 0.01; HRV-C group, P(2 tail) = 0.015) and lower median ages (HRV-A group, P(2 tail) = 0.049; HRV-C group, P(2 tail) = 0.009).

CONCLUSION

Our study shows that HRV-C strains circulate at a prevalence intermediate between HRV-A and HRV-B. The severity of clinical manifestations for HRV-C is comparable to that for HRV-A in children with CAP. These findings point to an important role of both HRV-A and HRV-C in pediatric CAP.

Authors+Show Affiliations

Christophe Mérieux Laboratory, IPB, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Dongcheng District, Beijing 100730, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20728404

Citation

Xiang, Zichun, et al. "Human Rhinovirus C Infections Mirror Those of Human Rhinovirus a in Children With Community-acquired Pneumonia." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 49, no. 2, 2010, pp. 94-9.
Xiang Z, Gonzalez R, Xie Z, et al. Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia. J Clin Virol. 2010;49(2):94-9.
Xiang, Z., Gonzalez, R., Xie, Z., Xiao, Y., Liu, J., Chen, L., Liu, C., Zhang, J., Ren, L., Vernet, G., Paranhos-Baccalà, G., Shen, K., Jin, Q., & Wang, J. (2010). Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 49(2), 94-9. https://doi.org/10.1016/j.jcv.2010.07.013
Xiang Z, et al. Human Rhinovirus C Infections Mirror Those of Human Rhinovirus a in Children With Community-acquired Pneumonia. J Clin Virol. 2010;49(2):94-9. PubMed PMID: 20728404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia. AU - Xiang,Zichun, AU - Gonzalez,Richard, AU - Xie,Zhengde, AU - Xiao,Yan, AU - Liu,Jun, AU - Chen,Lan, AU - Liu,Chunyan, AU - Zhang,Jing, AU - Ren,Lili, AU - Vernet,Guy, AU - Paranhos-Baccalà,Gláucia, AU - Shen,Kunling, AU - Jin,Qi, AU - Wang,Jianwei, Y1 - 2010/08/21/ PY - 2010/02/23/received PY - 2010/07/23/revised PY - 2010/07/27/accepted PY - 2010/8/24/entrez PY - 2010/8/24/pubmed PY - 2011/1/5/medline SP - 94 EP - 9 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 49 IS - 2 N2 - BACKGROUND: Human rhinoviruses (HRVs) are among the most common causes of community-acquired pneumonia (CAP) in children. However, the differential roles of the three HRV species HRV-A, HRV-B, and HRV-C in pediatric CAP are not fully understood. OBJECTIVE: To determine the distribution of HRV species and their roles in children hospitalized with CAP in Beijing, China. STUDY DESIGN: Nasopharyngeal aspirates were collected between April 2007 and March 2008 from 554 children with a primary diagnosis of CAP. HRVs in the clinical samples were detected by RT-PCR and by sequencing. Infections with other respiratory viruses were identified by PCR. RESULTS: HRVs were detected in 99 patients (17.87%). Among these patients, 51.52% tested positive for HRV-A, 38.38% for HRV-C, and 10.10% for HRV-B. HRVs were detected throughout the study period. The monthly distribution of HRV infections varied with HRV species. Median age, gender, symptoms, severity, and duration of hospitalization for single HRV-C infections were similar to those observed for single HRV-A infections. Co-infections with other respiratory viruses were detected in 57.58% of the HRV-positive children. HRV/RSV dual infections were correlated with a higher frequency of shortness of breath (HRV-A group, P(2 tail)= 0.01; HRV-C group, P(2 tail) = 0.015) and lower median ages (HRV-A group, P(2 tail) = 0.049; HRV-C group, P(2 tail) = 0.009). CONCLUSION: Our study shows that HRV-C strains circulate at a prevalence intermediate between HRV-A and HRV-B. The severity of clinical manifestations for HRV-C is comparable to that for HRV-A in children with CAP. These findings point to an important role of both HRV-A and HRV-C in pediatric CAP. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/20728404/Human_rhinovirus_C_infections_mirror_those_of_human_rhinovirus_A_in_children_with_community_acquired_pneumonia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(10)00302-1 DB - PRIME DP - Unbound Medicine ER -