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Toxico-pathological effects of sodium hypochlorite administration through drinking water in female Japanese quail (Coturnix japonica).
Hum Exp Toxicol. 2010 Sep; 29(9):779-88.HE

Abstract

Fifty female Japanese quail (Coturnix japonica) at 40 days were divided into five equal groups. Sodium hypochlorite was added in drinking water to provide 0, 25, 50, 200, 400 mg chlorine/L for 6 weeks. At week 7, the chlorine concentration of 25 and 50 mg groups was increased to 100 mg and further increased to 400, 1600 and 6400 mg at weeks 8, 9 and 10, respectively. At the end the experiment (week 10), all the birds were sacrificed. No clinical signs were observed in quail given 50 mg chlorine/L. Quail given 200-400 mg/L chlorine exhibited decreased feed intake, body weight and egg production. In addition, those given 1600-6400 mg/L chlorine also exhibited depression. Decreased hematocrit, erythrocyte, hemoglobin, leukocytes, plasma proteins and globulin were observed at 200 mg/L chlorine and higher concentration. Gross lesions were not observed in quail offered 200-400 mg/L chlorine for 6 weeks; however, those offered 1600-6400 mg/L chlorine exhibited atrophied pectoral muscles, prominently protruding keel bones, decreased weight of ovary and oviduct and a reduction in an area of the different segments of oviduct. The histopathological picture in mucosa of oviduct consisted of degenerated glandular cells. In some cases, glandular tissue was replaced by cord of cells and fibroblast. The present study suggested that sodium hypochlorite in drinking water yielding 50 mg/L chlorine was not toxic for 6 weeks. However, sodium hypochlorite providing 200 mg/L chlorine or higher concentrations in drinking water was toxic to the quail.

Authors+Show Affiliations

Department of Veterinary Pathology, University of Agriculture, Faisalabad, Pakistan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20729259

Citation

Hamdullah, , et al. "Toxico-pathological Effects of Sodium Hypochlorite Administration Through Drinking Water in Female Japanese Quail (Coturnix Japonica)." Human & Experimental Toxicology, vol. 29, no. 9, 2010, pp. 779-88.
Hamdullah , Khan MZ, Khan A, et al. Toxico-pathological effects of sodium hypochlorite administration through drinking water in female Japanese quail (Coturnix japonica). Hum Exp Toxicol. 2010;29(9):779-88.
Hamdullah, ., Khan, M. Z., Khan, A., & Javed, I. (2010). Toxico-pathological effects of sodium hypochlorite administration through drinking water in female Japanese quail (Coturnix japonica). Human & Experimental Toxicology, 29(9), 779-88. https://doi.org/10.1177/0960327110361755
Hamdullah , et al. Toxico-pathological Effects of Sodium Hypochlorite Administration Through Drinking Water in Female Japanese Quail (Coturnix Japonica). Hum Exp Toxicol. 2010;29(9):779-88. PubMed PMID: 20729259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxico-pathological effects of sodium hypochlorite administration through drinking water in female Japanese quail (Coturnix japonica). AU - Hamdullah,, AU - Khan,Muhammad Zargham, AU - Khan,Ahrar, AU - Javed,Ijaz, Y1 - 2010/02/10/ PY - 2010/8/24/entrez PY - 2010/8/24/pubmed PY - 2010/12/22/medline SP - 779 EP - 88 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 29 IS - 9 N2 - Fifty female Japanese quail (Coturnix japonica) at 40 days were divided into five equal groups. Sodium hypochlorite was added in drinking water to provide 0, 25, 50, 200, 400 mg chlorine/L for 6 weeks. At week 7, the chlorine concentration of 25 and 50 mg groups was increased to 100 mg and further increased to 400, 1600 and 6400 mg at weeks 8, 9 and 10, respectively. At the end the experiment (week 10), all the birds were sacrificed. No clinical signs were observed in quail given 50 mg chlorine/L. Quail given 200-400 mg/L chlorine exhibited decreased feed intake, body weight and egg production. In addition, those given 1600-6400 mg/L chlorine also exhibited depression. Decreased hematocrit, erythrocyte, hemoglobin, leukocytes, plasma proteins and globulin were observed at 200 mg/L chlorine and higher concentration. Gross lesions were not observed in quail offered 200-400 mg/L chlorine for 6 weeks; however, those offered 1600-6400 mg/L chlorine exhibited atrophied pectoral muscles, prominently protruding keel bones, decreased weight of ovary and oviduct and a reduction in an area of the different segments of oviduct. The histopathological picture in mucosa of oviduct consisted of degenerated glandular cells. In some cases, glandular tissue was replaced by cord of cells and fibroblast. The present study suggested that sodium hypochlorite in drinking water yielding 50 mg/L chlorine was not toxic for 6 weeks. However, sodium hypochlorite providing 200 mg/L chlorine or higher concentrations in drinking water was toxic to the quail. SN - 1477-0903 UR - https://www.unboundmedicine.com/medline/citation/20729259/Toxico_pathological_effects_of_sodium_hypochlorite_administration_through_drinking_water_in_female_Japanese_quail__Coturnix_japonica__ L2 - http://journals.sagepub.com/doi/full/10.1177/0960327110361755?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -