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Association of meat and fat intake with liver disease and hepatocellular carcinoma in the NIH-AARP cohort.

Abstract

BACKGROUND

Several plausible mechanisms, including fat, iron, heterocyclic amines, and N-nitroso compounds, link meat intake with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Few studies have investigated these associations.

METHODS

We prospectively examined the relationship between meat and associated exposures with CLD mortality (n = 551; not including HCC) and HCC incidence (n = 338) in 495 006 men and women of the National Institutes of Health-AARP Diet and Health Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the fifth (Q5) vs the first (Q1) quintile were estimated from multivariable adjusted Cox proportional hazards regression models. All tests of statistical significance were two-sided.

RESULTS

We found inverse associations between white meat and risk of CLD (HR = 0.52, 95% CI = 0.39 to 0.70, 7.5 vs 18.2 cases per 100 000 person-years) and HCC (HR = 0.52, 95% CI = 0.36 to 0.77, 5.8 vs 14.3 cases per 100 000 person-years). Red meat was associated with higher risk of CLD (HR = 2.59, 95% CI = 1.86 to 3.61, 22.3 vs 6.2 cases per 100 000 person-years) and HCC (HR = 1.74, 95% CI = 1.16 to 2.61, 14.9 vs 5.7 cases per 100 000 person-years). Among fat types, results were strongest for saturated fat (for CLD, HR = 3.50, 95% CI = 2.48 to 4.96, 23.0 vs 6.5 cases per 100 000 person-years; for HCC, HR = 1.87, 95% CI = 1.23 to 2.85, 14.5 vs 6.3 cases per 100 000 person-years). After mutual adjustment, risk estimates persisted for saturated fat, red meat, and white meat. Heme iron, processed meat, nitrate, and nitrite were positively associated with CLD but not with HCC. Individual heterocyclic amines, 2-amino-3,4,8-trimethylimidazo[4,5,-f]quinoxaline (DiMeIQx), 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), were not associated with either outcome.

CONCLUSION

Our results suggest that red meat and saturated fat may be associated with increased CLD and HCC risk, whereas white meat may be associated with reduced risk.

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  • Authors+Show Affiliations

    ,

    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd., Rockville, MD 20852, USA. freedmanne@mail.nih.gov

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    Source

    Journal of the National Cancer Institute 102:17 2010 Sep 08 pg 1354-65

    MeSH

    Aged
    Carcinoma, Hepatocellular
    Cohort Studies
    Dietary Fats
    Feeding Behavior
    Female
    Follow-Up Studies
    Hepatitis B
    Humans
    Incidence
    Liver Diseases
    Liver Neoplasms
    Male
    Meat
    Middle Aged
    Multivariate Analysis
    Nutrition Surveys
    Proportional Hazards Models
    Prospective Studies
    Research Design
    Risk Assessment
    Risk Factors
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    20729477

    Citation

    Freedman, Neal D., et al. "Association of Meat and Fat Intake With Liver Disease and Hepatocellular Carcinoma in the NIH-AARP Cohort." Journal of the National Cancer Institute, vol. 102, no. 17, 2010, pp. 1354-65.
    Freedman ND, Cross AJ, McGlynn KA, et al. Association of meat and fat intake with liver disease and hepatocellular carcinoma in the NIH-AARP cohort. J Natl Cancer Inst. 2010;102(17):1354-65.
    Freedman, N. D., Cross, A. J., McGlynn, K. A., Abnet, C. C., Park, Y., Hollenbeck, A. R., ... Sinha, R. (2010). Association of meat and fat intake with liver disease and hepatocellular carcinoma in the NIH-AARP cohort. Journal of the National Cancer Institute, 102(17), pp. 1354-65. doi:10.1093/jnci/djq301.
    Freedman ND, et al. Association of Meat and Fat Intake With Liver Disease and Hepatocellular Carcinoma in the NIH-AARP Cohort. J Natl Cancer Inst. 2010 Sep 8;102(17):1354-65. PubMed PMID: 20729477.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of meat and fat intake with liver disease and hepatocellular carcinoma in the NIH-AARP cohort. AU - Freedman,Neal D, AU - Cross,Amanda J, AU - McGlynn,Katherine A, AU - Abnet,Christian C, AU - Park,Yikyung, AU - Hollenbeck,Albert R, AU - Schatzkin,Arthur, AU - Everhart,James E, AU - Sinha,Rashmi, Y1 - 2010/08/20/ PY - 2010/8/24/entrez PY - 2010/8/24/pubmed PY - 2010/9/30/medline SP - 1354 EP - 65 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 102 IS - 17 N2 - BACKGROUND: Several plausible mechanisms, including fat, iron, heterocyclic amines, and N-nitroso compounds, link meat intake with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Few studies have investigated these associations. METHODS: We prospectively examined the relationship between meat and associated exposures with CLD mortality (n = 551; not including HCC) and HCC incidence (n = 338) in 495 006 men and women of the National Institutes of Health-AARP Diet and Health Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the fifth (Q5) vs the first (Q1) quintile were estimated from multivariable adjusted Cox proportional hazards regression models. All tests of statistical significance were two-sided. RESULTS: We found inverse associations between white meat and risk of CLD (HR = 0.52, 95% CI = 0.39 to 0.70, 7.5 vs 18.2 cases per 100 000 person-years) and HCC (HR = 0.52, 95% CI = 0.36 to 0.77, 5.8 vs 14.3 cases per 100 000 person-years). Red meat was associated with higher risk of CLD (HR = 2.59, 95% CI = 1.86 to 3.61, 22.3 vs 6.2 cases per 100 000 person-years) and HCC (HR = 1.74, 95% CI = 1.16 to 2.61, 14.9 vs 5.7 cases per 100 000 person-years). Among fat types, results were strongest for saturated fat (for CLD, HR = 3.50, 95% CI = 2.48 to 4.96, 23.0 vs 6.5 cases per 100 000 person-years; for HCC, HR = 1.87, 95% CI = 1.23 to 2.85, 14.5 vs 6.3 cases per 100 000 person-years). After mutual adjustment, risk estimates persisted for saturated fat, red meat, and white meat. Heme iron, processed meat, nitrate, and nitrite were positively associated with CLD but not with HCC. Individual heterocyclic amines, 2-amino-3,4,8-trimethylimidazo[4,5,-f]quinoxaline (DiMeIQx), 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), were not associated with either outcome. CONCLUSION: Our results suggest that red meat and saturated fat may be associated with increased CLD and HCC risk, whereas white meat may be associated with reduced risk. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/20729477/Association_of_meat_and_fat_intake_with_liver_disease_and_hepatocellular_carcinoma_in_the_NIH_AARP_cohort_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djq301 DB - PRIME DP - Unbound Medicine ER -