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Antidiabetic and antioxidant activity of Swietenia mahagoni in streptozotocin-induced diabetic rats.
Pharm Biol. 2010 Sep; 48(9):974-9.PB

Abstract

CONTEXT

Swietenia mahagoni L. Jacq. (Meliaceae) is a medium to large evergreen tree native to Southern Florida, Cuba, The Bahamas, Hispaniola, and Jamaica.

OBJECTIVE

To evaluate the antidiabetic and antioxidant potential of S. mahagoni bark.

MATERIALS AND METHODS

In the present study, the antidiabetic activity of the methanol extract of S. mahagoni (MESM) bark in streptozotocin (STZ; 65 mg/kg body weight)-induced diabetic rats was evaluated. Glibenclamide (0.5 mg/kg; orally) was taken as the reference drug. The blood glucose levels and body weights were measured every 5th day over a period of 15 days. Antioxidant effects were assayed in diabetic rats by estimating thiobarbituric acid reactive substances (TBARS), glutathione (GSH), and catalase (CAT) levels.

RESULTS AND DISCUSSION

Oral administration of MESM at the doses of 25 and 50 mg/kg b.w. resulted in a significant (p < 0.001) reduction in blood glucose levels in diabetic rats. Body weights were significantly (p < 0.001) reduced in STZ-induced diabetic rats when compared to normal rats, while the extract significantly restored body weight. The present study was further undertaken to evaluate the antioxidant activity of MESM in STZ-induced diabetic rats. Decreased levels of TBARS and increased levels of GSH and CAT activity indicated a reduction in free radical formation in tissues such as the liver and kidney of diabetic rats.

CONCLUSION

These findings showed the significant hypoglycemic and antioxidant activity of the extract (MESM) in diabetic rats.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20731547

Citation

Panda, Siva Prasad, et al. "Antidiabetic and Antioxidant Activity of Swietenia Mahagoni in Streptozotocin-induced Diabetic Rats." Pharmaceutical Biology, vol. 48, no. 9, 2010, pp. 974-9.
Panda SP, Haldar PK, Bera S, et al. Antidiabetic and antioxidant activity of Swietenia mahagoni in streptozotocin-induced diabetic rats. Pharm Biol. 2010;48(9):974-9.
Panda, S. P., Haldar, P. K., Bera, S., Adhikary, S., & Kandar, C. C. (2010). Antidiabetic and antioxidant activity of Swietenia mahagoni in streptozotocin-induced diabetic rats. Pharmaceutical Biology, 48(9), 974-9. https://doi.org/10.3109/13880200903390051
Panda SP, et al. Antidiabetic and Antioxidant Activity of Swietenia Mahagoni in Streptozotocin-induced Diabetic Rats. Pharm Biol. 2010;48(9):974-9. PubMed PMID: 20731547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic and antioxidant activity of Swietenia mahagoni in streptozotocin-induced diabetic rats. AU - Panda,Siva Prasad, AU - Haldar,Pallab Kanti, AU - Bera,Samit, AU - Adhikary,Soumitra, AU - Kandar,Chandi Charan, PY - 2010/8/25/entrez PY - 2010/8/25/pubmed PY - 2011/1/14/medline SP - 974 EP - 9 JF - Pharmaceutical biology JO - Pharm Biol VL - 48 IS - 9 N2 - CONTEXT: Swietenia mahagoni L. Jacq. (Meliaceae) is a medium to large evergreen tree native to Southern Florida, Cuba, The Bahamas, Hispaniola, and Jamaica. OBJECTIVE: To evaluate the antidiabetic and antioxidant potential of S. mahagoni bark. MATERIALS AND METHODS: In the present study, the antidiabetic activity of the methanol extract of S. mahagoni (MESM) bark in streptozotocin (STZ; 65 mg/kg body weight)-induced diabetic rats was evaluated. Glibenclamide (0.5 mg/kg; orally) was taken as the reference drug. The blood glucose levels and body weights were measured every 5th day over a period of 15 days. Antioxidant effects were assayed in diabetic rats by estimating thiobarbituric acid reactive substances (TBARS), glutathione (GSH), and catalase (CAT) levels. RESULTS AND DISCUSSION: Oral administration of MESM at the doses of 25 and 50 mg/kg b.w. resulted in a significant (p < 0.001) reduction in blood glucose levels in diabetic rats. Body weights were significantly (p < 0.001) reduced in STZ-induced diabetic rats when compared to normal rats, while the extract significantly restored body weight. The present study was further undertaken to evaluate the antioxidant activity of MESM in STZ-induced diabetic rats. Decreased levels of TBARS and increased levels of GSH and CAT activity indicated a reduction in free radical formation in tissues such as the liver and kidney of diabetic rats. CONCLUSION: These findings showed the significant hypoglycemic and antioxidant activity of the extract (MESM) in diabetic rats. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/20731547/Antidiabetic_and_antioxidant_activity_of_Swietenia_mahagoni_in_streptozotocin_induced_diabetic_rats_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880200903390051 DB - PRIME DP - Unbound Medicine ER -