Water-extracted polysaccharides from Azadirachta indica leaves: Structural features, chemical modification and anti-bovine herpesvirus type 1 (BoHV-1) activity.Int J Biol Macromol. 2010 Dec 01; 47(5):640-5.IJ
Abstract
In this study, we have analyzed the pectic arabinogalactan isolated from Azadirachta indica and its chemically sulfated derivative. The native polysaccharide had an apparent molecular mass of 80 kDa and is made up of (1→5)-/(1→3,5)-linked α-L-arabinosyl, (1→3)-/(1→6)-/(1→3,6)-linked β-D-galactosyl, and terminal-rhamnosyl and α-l-arabinosyl residues. These macromolecules showed activity against bovine herpesvirus type-1. Their inhibitory concentration 50% values ranging from 31.12 to 105.25 μg/ml were lower than the cytotoxicity values (>1600-1440 μg/ml). The anti-viral effect was exerted during virus adsorption to the cell. Anionic groups in particular the sulfate groups appeared to be very important for the anti-herpetic activity of these polymers.
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MeSH
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
20732349
Citation
Saha, Sudipta, et al. "Water-extracted Polysaccharides From Azadirachta Indica Leaves: Structural Features, Chemical Modification and Anti-bovine Herpesvirus Type 1 (BoHV-1) Activity." International Journal of Biological Macromolecules, vol. 47, no. 5, 2010, pp. 640-5.
Saha S, Galhardi LC, Yamamoto KA, et al. Water-extracted polysaccharides from Azadirachta indica leaves: Structural features, chemical modification and anti-bovine herpesvirus type 1 (BoHV-1) activity. Int J Biol Macromol. 2010;47(5):640-5.
Saha, S., Galhardi, L. C., Yamamoto, K. A., Linhares, R. E., Bandyopadhyay, S. S., Sinha, S., Nozawa, C., & Ray, B. (2010). Water-extracted polysaccharides from Azadirachta indica leaves: Structural features, chemical modification and anti-bovine herpesvirus type 1 (BoHV-1) activity. International Journal of Biological Macromolecules, 47(5), 640-5. https://doi.org/10.1016/j.ijbiomac.2010.08.011
Saha S, et al. Water-extracted Polysaccharides From Azadirachta Indica Leaves: Structural Features, Chemical Modification and Anti-bovine Herpesvirus Type 1 (BoHV-1) Activity. Int J Biol Macromol. 2010 Dec 1;47(5):640-5. PubMed PMID: 20732349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Water-extracted polysaccharides from Azadirachta indica leaves: Structural features, chemical modification and anti-bovine herpesvirus type 1 (BoHV-1) activity.
AU - Saha,Sudipta,
AU - Galhardi,Ligia C F,
AU - Yamamoto,Kristie A,
AU - Linhares,Rosa Elisa C,
AU - Bandyopadhyay,Shruti S,
AU - Sinha,Sharmistha,
AU - Nozawa,Carlos,
AU - Ray,Bimalendu,
Y1 - 2010/08/21/
PY - 2010/07/13/received
PY - 2010/08/15/revised
PY - 2010/08/17/accepted
PY - 2010/8/25/entrez
PY - 2010/8/25/pubmed
PY - 2011/2/8/medline
SP - 640
EP - 5
JF - International journal of biological macromolecules
JO - Int J Biol Macromol
VL - 47
IS - 5
N2 - In this study, we have analyzed the pectic arabinogalactan isolated from Azadirachta indica and its chemically sulfated derivative. The native polysaccharide had an apparent molecular mass of 80 kDa and is made up of (1→5)-/(1→3,5)-linked α-L-arabinosyl, (1→3)-/(1→6)-/(1→3,6)-linked β-D-galactosyl, and terminal-rhamnosyl and α-l-arabinosyl residues. These macromolecules showed activity against bovine herpesvirus type-1. Their inhibitory concentration 50% values ranging from 31.12 to 105.25 μg/ml were lower than the cytotoxicity values (>1600-1440 μg/ml). The anti-viral effect was exerted during virus adsorption to the cell. Anionic groups in particular the sulfate groups appeared to be very important for the anti-herpetic activity of these polymers.
SN - 1879-0003
UR - https://www.unboundmedicine.com/medline/citation/20732349/Water_extracted_polysaccharides_from_Azadirachta_indica_leaves:_Structural_features_chemical_modification_and_anti_bovine_herpesvirus_type_1__BoHV_1__activity_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(10)00259-X
DB - PRIME
DP - Unbound Medicine
ER -
