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Tumor necrosis factor-alpha, transforming growth factor-β1, and interleukin-10 gene polymorphisms: implication in protection or susceptibility to dengue hemorrhagic fever.
Hum Immunol. 2010 Nov; 71(11):1135-40.HI

Abstract

Dengue virus infection has emerged as one of the most important arthropod-borne viral diseases. Some dengue infected individuals develop the severe, life-threatening form of the disease, dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Host genetic factors may be relevant and may predispose some individuals to the severe illness. Human leukocyte antigen (HLA), FcγR, tumor necrosis factor (TNF)-α, and dendritic cell-specific intracellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), among others genes have been associated with the pathogenesis of dengue. Little is known, however, about the predictive value of cytokine genotypes for the clinical outcome of dengue infection. In this study, the TNF-α, interleukin (IL)-6, interferon (IFN)-γ, IL-10 and transforming growth factor (TGF)-β1 gene single nucleotide polymorphisms (SNP) were studied by polymerase chain reaction-sequence-specific primer in a group of individuals with the antecedent of DHF during a secondary infection in the sequence dengue 1/dengue 2. A control group was also included. TNF-α (-308) A allele and IL-10 (-1082/-819/-592) ACC/ATA haplotype were significantly associated with DHF. TNF-α (-308) GG and TGF-β1 (c25) GG genotypes were associated with protection. Our results suggest that genetic predisposition to a high TNF-α production and a low IL-10 production seems to increase the susceptibility to DHF during a secondary dengue 2 infection, whereas TGF-β1 high producers might be protected for developing DHF.

Authors+Show Affiliations

PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Institute for Tropical Medicine Pedro Kouri, Havana, Cuba. anab@ipk.sld.cuNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20732366

Citation

Perez, Ana B., et al. "Tumor Necrosis Factor-alpha, Transforming Growth Factor-β1, and Interleukin-10 Gene Polymorphisms: Implication in Protection or Susceptibility to Dengue Hemorrhagic Fever." Human Immunology, vol. 71, no. 11, 2010, pp. 1135-40.
Perez AB, Sierra B, Garcia G, et al. Tumor necrosis factor-alpha, transforming growth factor-β1, and interleukin-10 gene polymorphisms: implication in protection or susceptibility to dengue hemorrhagic fever. Hum Immunol. 2010;71(11):1135-40.
Perez, A. B., Sierra, B., Garcia, G., Aguirre, E., Babel, N., Alvarez, M., Sanchez, L., Valdes, L., Volk, H. D., & Guzman, M. G. (2010). Tumor necrosis factor-alpha, transforming growth factor-β1, and interleukin-10 gene polymorphisms: implication in protection or susceptibility to dengue hemorrhagic fever. Human Immunology, 71(11), 1135-40. https://doi.org/10.1016/j.humimm.2010.08.004
Perez AB, et al. Tumor Necrosis Factor-alpha, Transforming Growth Factor-β1, and Interleukin-10 Gene Polymorphisms: Implication in Protection or Susceptibility to Dengue Hemorrhagic Fever. Hum Immunol. 2010;71(11):1135-40. PubMed PMID: 20732366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tumor necrosis factor-alpha, transforming growth factor-β1, and interleukin-10 gene polymorphisms: implication in protection or susceptibility to dengue hemorrhagic fever. AU - Perez,Ana B, AU - Sierra,Beatriz, AU - Garcia,Gissel, AU - Aguirre,Eglis, AU - Babel,Nina, AU - Alvarez,Mayling, AU - Sanchez,Licel, AU - Valdes,Luis, AU - Volk,Hans D, AU - Guzman,Maria G, Y1 - 2010/08/21/ PY - 2010/02/11/received PY - 2010/07/18/revised PY - 2010/08/16/accepted PY - 2010/8/25/entrez PY - 2010/8/25/pubmed PY - 2011/5/6/medline SP - 1135 EP - 40 JF - Human immunology JO - Hum Immunol VL - 71 IS - 11 N2 - Dengue virus infection has emerged as one of the most important arthropod-borne viral diseases. Some dengue infected individuals develop the severe, life-threatening form of the disease, dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Host genetic factors may be relevant and may predispose some individuals to the severe illness. Human leukocyte antigen (HLA), FcγR, tumor necrosis factor (TNF)-α, and dendritic cell-specific intracellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), among others genes have been associated with the pathogenesis of dengue. Little is known, however, about the predictive value of cytokine genotypes for the clinical outcome of dengue infection. In this study, the TNF-α, interleukin (IL)-6, interferon (IFN)-γ, IL-10 and transforming growth factor (TGF)-β1 gene single nucleotide polymorphisms (SNP) were studied by polymerase chain reaction-sequence-specific primer in a group of individuals with the antecedent of DHF during a secondary infection in the sequence dengue 1/dengue 2. A control group was also included. TNF-α (-308) A allele and IL-10 (-1082/-819/-592) ACC/ATA haplotype were significantly associated with DHF. TNF-α (-308) GG and TGF-β1 (c25) GG genotypes were associated with protection. Our results suggest that genetic predisposition to a high TNF-α production and a low IL-10 production seems to increase the susceptibility to DHF during a secondary dengue 2 infection, whereas TGF-β1 high producers might be protected for developing DHF. SN - 1879-1166 UR - https://www.unboundmedicine.com/medline/citation/20732366/Tumor_necrosis_factor_alpha_transforming_growth_factor_β1_and_interleukin_10_gene_polymorphisms:_implication_in_protection_or_susceptibility_to_dengue_hemorrhagic_fever_ DB - PRIME DP - Unbound Medicine ER -