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Oxidative imbalance in child and adolescent patients with attention-deficit/hyperactivity disorder.

Abstract

Various psychological, social, genetic, and biochemical factors are thought to be involved in the aetiology of attention-deficit/hyperactivity disorder (ADHD). However, few studies have evaluated the biochemical basis of ADHD. In the present study, we evaluate whether levels of nitric oxide pool (NO+NO(2)(-)) and malondialdehyde (MDA) oxidants as well as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) antioxidant enzyme activities are associated with ADHD. The sample population consisted of thirty-five child or adolescent patients diagnosed with ADHD according to DSM-IV-TR criteria. Thirty-five healthy subjects also were included in the study as controls. Venous blood samples were collected, and NO pool and MDA levels as well as SOD, GSH-Px, and CAT activities were measured. NO and MDA levels of the patients were significantly higher than the controls. GSH-Px activities of the patients were significantly lower than the controls. CAT activities of the patients were higher than the controls; however, the difference was not statistically significant. There were no significant differences in SOD activity between the patient and control groups. Remarkably high levels of NO pool and MDA oxidants as well as low GSH-Px activities suggest an oxidative imbalance in paediatric patients with ADHD. CAT activities may be increased in response to increased oxidant levels.

Authors+Show Affiliations

Gulhane Military Medical Academy, Child and Adolescent Psychiatry, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20732373

Citation

Ceylan, Mehmet, et al. "Oxidative Imbalance in Child and Adolescent Patients With Attention-deficit/hyperactivity Disorder." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 34, no. 8, 2010, pp. 1491-4.
Ceylan M, Sener S, Bayraktar AC, et al. Oxidative imbalance in child and adolescent patients with attention-deficit/hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(8):1491-4.
Ceylan, M., Sener, S., Bayraktar, A. C., & Kavutcu, M. (2010). Oxidative imbalance in child and adolescent patients with attention-deficit/hyperactivity disorder. Progress in Neuro-psychopharmacology & Biological Psychiatry, 34(8), pp. 1491-4. doi:10.1016/j.pnpbp.2010.08.010.
Ceylan M, et al. Oxidative Imbalance in Child and Adolescent Patients With Attention-deficit/hyperactivity Disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Dec 1;34(8):1491-4. PubMed PMID: 20732373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative imbalance in child and adolescent patients with attention-deficit/hyperactivity disorder. AU - Ceylan,Mehmet, AU - Sener,Sahnur, AU - Bayraktar,Aslıhan Cavunt, AU - Kavutcu,Mustafa, Y1 - 2010/08/20/ PY - 2010/04/07/received PY - 2010/08/03/revised PY - 2010/08/16/accepted PY - 2010/8/25/entrez PY - 2010/8/25/pubmed PY - 2011/11/15/medline SP - 1491 EP - 4 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 34 IS - 8 N2 - Various psychological, social, genetic, and biochemical factors are thought to be involved in the aetiology of attention-deficit/hyperactivity disorder (ADHD). However, few studies have evaluated the biochemical basis of ADHD. In the present study, we evaluate whether levels of nitric oxide pool (NO+NO(2)(-)) and malondialdehyde (MDA) oxidants as well as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) antioxidant enzyme activities are associated with ADHD. The sample population consisted of thirty-five child or adolescent patients diagnosed with ADHD according to DSM-IV-TR criteria. Thirty-five healthy subjects also were included in the study as controls. Venous blood samples were collected, and NO pool and MDA levels as well as SOD, GSH-Px, and CAT activities were measured. NO and MDA levels of the patients were significantly higher than the controls. GSH-Px activities of the patients were significantly lower than the controls. CAT activities of the patients were higher than the controls; however, the difference was not statistically significant. There were no significant differences in SOD activity between the patient and control groups. Remarkably high levels of NO pool and MDA oxidants as well as low GSH-Px activities suggest an oxidative imbalance in paediatric patients with ADHD. CAT activities may be increased in response to increased oxidant levels. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/20732373/Oxidative_imbalance_in_child_and_adolescent_patients_with_attention_deficit/hyperactivity_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(10)00313-1 DB - PRIME DP - Unbound Medicine ER -