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Oxidative imbalance in child and adolescent patients with attention-deficit/hyperactivity disorder.

Abstract

Various psychological, social, genetic, and biochemical factors are thought to be involved in the aetiology of attention-deficit/hyperactivity disorder (ADHD). However, few studies have evaluated the biochemical basis of ADHD. In the present study, we evaluate whether levels of nitric oxide pool (NO+NO(2)(-)) and malondialdehyde (MDA) oxidants as well as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) antioxidant enzyme activities are associated with ADHD. The sample population consisted of thirty-five child or adolescent patients diagnosed with ADHD according to DSM-IV-TR criteria. Thirty-five healthy subjects also were included in the study as controls. Venous blood samples were collected, and NO pool and MDA levels as well as SOD, GSH-Px, and CAT activities were measured. NO and MDA levels of the patients were significantly higher than the controls. GSH-Px activities of the patients were significantly lower than the controls. CAT activities of the patients were higher than the controls; however, the difference was not statistically significant. There were no significant differences in SOD activity between the patient and control groups. Remarkably high levels of NO pool and MDA oxidants as well as low GSH-Px activities suggest an oxidative imbalance in paediatric patients with ADHD. CAT activities may be increased in response to increased oxidant levels.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Gulhane Military Medical Academy, Child and Adolescent Psychiatry, Ankara, Turkey.

    , ,

    Source

    MeSH

    Adolescent
    Age Factors
    Attention Deficit Disorder with Hyperactivity
    Biomarkers
    Catalase
    Child
    Female
    Humans
    Male
    Oxidants
    Oxidation-Reduction
    Oxidative Stress
    Up-Regulation

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20732373

    Citation

    Ceylan, Mehmet, et al. "Oxidative Imbalance in Child and Adolescent Patients With Attention-deficit/hyperactivity Disorder." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 34, no. 8, 2010, pp. 1491-4.
    Ceylan M, Sener S, Bayraktar AC, et al. Oxidative imbalance in child and adolescent patients with attention-deficit/hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(8):1491-4.
    Ceylan, M., Sener, S., Bayraktar, A. C., & Kavutcu, M. (2010). Oxidative imbalance in child and adolescent patients with attention-deficit/hyperactivity disorder. Progress in Neuro-psychopharmacology & Biological Psychiatry, 34(8), pp. 1491-4. doi:10.1016/j.pnpbp.2010.08.010.
    Ceylan M, et al. Oxidative Imbalance in Child and Adolescent Patients With Attention-deficit/hyperactivity Disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Dec 1;34(8):1491-4. PubMed PMID: 20732373.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oxidative imbalance in child and adolescent patients with attention-deficit/hyperactivity disorder. AU - Ceylan,Mehmet, AU - Sener,Sahnur, AU - Bayraktar,Aslıhan Cavunt, AU - Kavutcu,Mustafa, Y1 - 2010/08/20/ PY - 2010/04/07/received PY - 2010/08/03/revised PY - 2010/08/16/accepted PY - 2010/8/25/entrez PY - 2010/8/25/pubmed PY - 2011/11/15/medline SP - 1491 EP - 4 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 34 IS - 8 N2 - Various psychological, social, genetic, and biochemical factors are thought to be involved in the aetiology of attention-deficit/hyperactivity disorder (ADHD). However, few studies have evaluated the biochemical basis of ADHD. In the present study, we evaluate whether levels of nitric oxide pool (NO+NO(2)(-)) and malondialdehyde (MDA) oxidants as well as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) antioxidant enzyme activities are associated with ADHD. The sample population consisted of thirty-five child or adolescent patients diagnosed with ADHD according to DSM-IV-TR criteria. Thirty-five healthy subjects also were included in the study as controls. Venous blood samples were collected, and NO pool and MDA levels as well as SOD, GSH-Px, and CAT activities were measured. NO and MDA levels of the patients were significantly higher than the controls. GSH-Px activities of the patients were significantly lower than the controls. CAT activities of the patients were higher than the controls; however, the difference was not statistically significant. There were no significant differences in SOD activity between the patient and control groups. Remarkably high levels of NO pool and MDA oxidants as well as low GSH-Px activities suggest an oxidative imbalance in paediatric patients with ADHD. CAT activities may be increased in response to increased oxidant levels. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/20732373/Oxidative_imbalance_in_child_and_adolescent_patients_with_attention_deficit/hyperactivity_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(10)00313-1 DB - PRIME DP - Unbound Medicine ER -