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Genetic correlation between current circulating H1N1 swine and human influenza viruses.
J Clin Virol. 2010 Nov; 49(3):186-91.JC

Abstract

BACKGROUND

H1N1 is the main subtype influenza A virus circulating in human and swine population, and has long been a threat to economy and public health.

OBJECTIVE

To explore the genetic correlation between current circulating H1N1 swine and human influenza viruses.

STUDY DESIGN

Three new H1N1 swine influenza viruses (SIVs) were isolated and genomes sequencing were conducted followed by phylogenetic and molecular analysis of all swine and human H1N1 influenza viruses isolated in China in the past five years.

RESULTS

Homology and phylogenetic analysis revealed that the three isolates possessed different characteristics: the genome of A/Swine/Shandong/1112/2008 was closely related to that of classical H1N1 SIV, while A/Swine/Shandong/1123/2008 was a reassortant with NS gene from the human-like H3N2 influenza virus and other genes from the classical H1N1 SIV, and A/Swine/Fujian/0325/2008 fell into a lineage of seasonal human H1N1 influenza viruses. Genetically, 2009 H1N1 influenza A viruses (2009 H1N1) in China were contiguous to the SIV lineages rather than the seasonal H1N1 human influenza virus's lineage. Furthermore, molecular analysis among human and swine influenza viruses provided more detail information for understanding their genetic correlation.

CONCLUSIONS

These results suggested that in China in the past five years, the classical, avian-like and human-like H1N1 SIV existed in swine herds and the reassortment between H1N1 swine and H3N2 human influenza viruses was identified. In addition, the present data showed no evidence to support a strong correlation between the 2009 H1N1 and the swine influenza virus circulating in China.

Authors+Show Affiliations

Center for Molecular Virology, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20732830

Citation

Lu, Lu, et al. "Genetic Correlation Between Current Circulating H1N1 Swine and Human Influenza Viruses." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 49, no. 3, 2010, pp. 186-91.
Lu L, Yin Y, Sun Z, et al. Genetic correlation between current circulating H1N1 swine and human influenza viruses. J Clin Virol. 2010;49(3):186-91.
Lu, L., Yin, Y., Sun, Z., Gao, L., Gao, G. F., Liu, S., Sun, L., & Liu, W. (2010). Genetic correlation between current circulating H1N1 swine and human influenza viruses. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 49(3), 186-91. https://doi.org/10.1016/j.jcv.2010.07.018
Lu L, et al. Genetic Correlation Between Current Circulating H1N1 Swine and Human Influenza Viruses. J Clin Virol. 2010;49(3):186-91. PubMed PMID: 20732830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic correlation between current circulating H1N1 swine and human influenza viruses. AU - Lu,Lu, AU - Yin,Yanbo, AU - Sun,Zhongsheng, AU - Gao,Lei, AU - Gao,George F, AU - Liu,Sidang, AU - Sun,Lei, AU - Liu,Wenjun, Y1 - 2010/08/21/ PY - 2010/02/08/received PY - 2010/07/16/revised PY - 2010/07/27/accepted PY - 2010/8/25/entrez PY - 2010/8/25/pubmed PY - 2011/1/19/medline SP - 186 EP - 91 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 49 IS - 3 N2 - BACKGROUND: H1N1 is the main subtype influenza A virus circulating in human and swine population, and has long been a threat to economy and public health. OBJECTIVE: To explore the genetic correlation between current circulating H1N1 swine and human influenza viruses. STUDY DESIGN: Three new H1N1 swine influenza viruses (SIVs) were isolated and genomes sequencing were conducted followed by phylogenetic and molecular analysis of all swine and human H1N1 influenza viruses isolated in China in the past five years. RESULTS: Homology and phylogenetic analysis revealed that the three isolates possessed different characteristics: the genome of A/Swine/Shandong/1112/2008 was closely related to that of classical H1N1 SIV, while A/Swine/Shandong/1123/2008 was a reassortant with NS gene from the human-like H3N2 influenza virus and other genes from the classical H1N1 SIV, and A/Swine/Fujian/0325/2008 fell into a lineage of seasonal human H1N1 influenza viruses. Genetically, 2009 H1N1 influenza A viruses (2009 H1N1) in China were contiguous to the SIV lineages rather than the seasonal H1N1 human influenza virus's lineage. Furthermore, molecular analysis among human and swine influenza viruses provided more detail information for understanding their genetic correlation. CONCLUSIONS: These results suggested that in China in the past five years, the classical, avian-like and human-like H1N1 SIV existed in swine herds and the reassortment between H1N1 swine and H3N2 human influenza viruses was identified. In addition, the present data showed no evidence to support a strong correlation between the 2009 H1N1 and the swine influenza virus circulating in China. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/20732830/Genetic_correlation_between_current_circulating_H1N1_swine_and_human_influenza_viruses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(10)00307-0 DB - PRIME DP - Unbound Medicine ER -