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Role of p53 and p21 polymorphisms in the risk of cervical cancer among Chinese women.
Acta Biochim Biophys Sin (Shanghai). 2010 Sep; 42(9):671-6.AB

Abstract

The objective of this study was to identify whether polymorphic variants of p53 at codon 72 and p21 at codon 31 were associated with increased risk for cervical cancer, either independently or jointly, among Chinese women from southern Han. We genotyped p53 codon 72 and p21 codon 31 polymorphisms of peripheral blood DNA from 104 cervical cancer patients and 160 controls. Genotyping was confirmed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct DNA sequencing. We observed an increased risk of cervical cancer associated with the p53 Arg/Arg (OR, 2.25; 95% CI, 1.11-4.54) or p21 Ser/Ser (OR, 2.09; 95% CI, 1.04-4.19) genotype, compared with the p53 Pro/Pro or p21 Arg/Arg genotype, respectively. In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes. These findings suggest that there is a significant association between the genetic polymorphism of p53, p21, and the risk of cervical cancer among Chinese southern women, and there is a possible gene-gene interaction in the incidence of cervical cancer.

Authors+Show Affiliations

Central South University, Changsha, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20732856

Citation

Jiang, Pei, et al. "Role of P53 and P21 Polymorphisms in the Risk of Cervical Cancer Among Chinese Women." Acta Biochimica Et Biophysica Sinica, vol. 42, no. 9, 2010, pp. 671-6.
Jiang P, Liu J, Li W, et al. Role of p53 and p21 polymorphisms in the risk of cervical cancer among Chinese women. Acta Biochim Biophys Sin (Shanghai). 2010;42(9):671-6.
Jiang, P., Liu, J., Li, W., Zeng, X., & Tang, J. (2010). Role of p53 and p21 polymorphisms in the risk of cervical cancer among Chinese women. Acta Biochimica Et Biophysica Sinica, 42(9), 671-6. https://doi.org/10.1093/abbs/gmq069
Jiang P, et al. Role of P53 and P21 Polymorphisms in the Risk of Cervical Cancer Among Chinese Women. Acta Biochim Biophys Sin (Shanghai). 2010;42(9):671-6. PubMed PMID: 20732856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of p53 and p21 polymorphisms in the risk of cervical cancer among Chinese women. AU - Jiang,Pei, AU - Liu,Jianxin, AU - Li,Wen, AU - Zeng,Xiaoxi, AU - Tang,Jianxin, Y1 - 2010/08/07/ PY - 2010/8/25/entrez PY - 2010/8/25/pubmed PY - 2011/2/8/medline SP - 671 EP - 6 JF - Acta biochimica et biophysica Sinica JO - Acta Biochim Biophys Sin (Shanghai) VL - 42 IS - 9 N2 - The objective of this study was to identify whether polymorphic variants of p53 at codon 72 and p21 at codon 31 were associated with increased risk for cervical cancer, either independently or jointly, among Chinese women from southern Han. We genotyped p53 codon 72 and p21 codon 31 polymorphisms of peripheral blood DNA from 104 cervical cancer patients and 160 controls. Genotyping was confirmed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct DNA sequencing. We observed an increased risk of cervical cancer associated with the p53 Arg/Arg (OR, 2.25; 95% CI, 1.11-4.54) or p21 Ser/Ser (OR, 2.09; 95% CI, 1.04-4.19) genotype, compared with the p53 Pro/Pro or p21 Arg/Arg genotype, respectively. In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes. These findings suggest that there is a significant association between the genetic polymorphism of p53, p21, and the risk of cervical cancer among Chinese southern women, and there is a possible gene-gene interaction in the incidence of cervical cancer. SN - 1745-7270 UR - https://www.unboundmedicine.com/medline/citation/20732856/Role_of_p53_and_p21_polymorphisms_in_the_risk_of_cervical_cancer_among_Chinese_women_ L2 - https://academic.oup.com/abbs/article-lookup/doi/10.1093/abbs/gmq069 DB - PRIME DP - Unbound Medicine ER -