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Chitosan microspheres of aceclofenac: in vitro and in vivo evaluation.
Pharm Dev Technol. 2010 Sep-Oct; 15(5):442-51.PD

Abstract

The objective of this investigation was to achieve controlled drug release of Aceclofenac (ACE) microspheres and to minimize local side-effects in the gastrointestinal tract (GIT). Sustained release chitosan microspheres containing ACE were prepared using double-emulsion solvent evaporation method (O/W/O). Chitosan microspheres were prepared by varying drug to polymer ratio (1:3, 1:4, 1:5 and 1:6). Microspheres were characterized for morphology, swelling behavior, mucoadhesive properties, FTIR and DSC study, drug loading efficiency, in vitro release, release kinetics, and in vivo study was performed on rat model. ACE-loaded microspheres were successfully prepared having production yield, 57-70% w/w. Drug encapsulation efficiency was ranging from 53-72% w/w, Scanning electron microscopy (SEM) revealed particle size of microspheres was between 39 and 55 mum. FTIR spectra and DSC thermograms demonstrated no interaction between drug and polymer. The in vitro release profiles of drug from chitosan microspheres showed sustained-release pattern of the drug in phosphate buffer, pH 6.8. In vitro release data showed correlation (r2 > 0.98), good fit with Higuchi/Korsmeyer-Peppas models, and exhibited Fickian diffusion. ACE microspheres demonstrated controlled delivery of aceclofenac and apparently, no G.I.T. erosion was noticed.

Authors+Show Affiliations

Indukaka Ipcowala College of Pharmacy, Vithal Udyognagar, New Vallabh Vidyanagar, Anand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20735299

Citation

Nagda, Chirag, et al. "Chitosan Microspheres of Aceclofenac: in Vitro and in Vivo Evaluation." Pharmaceutical Development and Technology, vol. 15, no. 5, 2010, pp. 442-51.
Nagda C, Chotai N, Patel S, et al. Chitosan microspheres of aceclofenac: in vitro and in vivo evaluation. Pharm Dev Technol. 2010;15(5):442-51.
Nagda, C., Chotai, N., Patel, S., Nagda, D., Patel, U., & Soni, T. (2010). Chitosan microspheres of aceclofenac: in vitro and in vivo evaluation. Pharmaceutical Development and Technology, 15(5), 442-51. https://doi.org/10.3109/10837450903286503
Nagda C, et al. Chitosan Microspheres of Aceclofenac: in Vitro and in Vivo Evaluation. Pharm Dev Technol. 2010 Sep-Oct;15(5):442-51. PubMed PMID: 20735299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chitosan microspheres of aceclofenac: in vitro and in vivo evaluation. AU - Nagda,Chirag, AU - Chotai,Narendra, AU - Patel,Sandip, AU - Nagda,Dhruti, AU - Patel,Upendra, AU - Soni,Tejal, PY - 2010/8/26/entrez PY - 2010/8/26/pubmed PY - 2010/12/14/medline SP - 442 EP - 51 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 15 IS - 5 N2 - The objective of this investigation was to achieve controlled drug release of Aceclofenac (ACE) microspheres and to minimize local side-effects in the gastrointestinal tract (GIT). Sustained release chitosan microspheres containing ACE were prepared using double-emulsion solvent evaporation method (O/W/O). Chitosan microspheres were prepared by varying drug to polymer ratio (1:3, 1:4, 1:5 and 1:6). Microspheres were characterized for morphology, swelling behavior, mucoadhesive properties, FTIR and DSC study, drug loading efficiency, in vitro release, release kinetics, and in vivo study was performed on rat model. ACE-loaded microspheres were successfully prepared having production yield, 57-70% w/w. Drug encapsulation efficiency was ranging from 53-72% w/w, Scanning electron microscopy (SEM) revealed particle size of microspheres was between 39 and 55 mum. FTIR spectra and DSC thermograms demonstrated no interaction between drug and polymer. The in vitro release profiles of drug from chitosan microspheres showed sustained-release pattern of the drug in phosphate buffer, pH 6.8. In vitro release data showed correlation (r2 > 0.98), good fit with Higuchi/Korsmeyer-Peppas models, and exhibited Fickian diffusion. ACE microspheres demonstrated controlled delivery of aceclofenac and apparently, no G.I.T. erosion was noticed. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/20735299/Chitosan_microspheres_of_aceclofenac:_in_vitro_and_in_vivo_evaluation_ L2 - http://www.tandfonline.com/doi/full/10.3109/10837450903286503 DB - PRIME DP - Unbound Medicine ER -