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Effect of drug-carrier interaction on the dissolution behavior of solid dispersion tablets.
Pharm Dev Technol. 2010 Sep-Oct; 15(5):460-8.PD

Abstract

The objective of this study was to compare the dissolution behavior of tablets prepared from solid dispersions with and without drug-carrier interactions. Diazepam and nifedipine were used as model drugs. Two types of carriers were used; polyvinylpyrrolidone (PVP K12, K30 and K60) and saccharides (inulin 1.8 kDa, 4 kDa and 6.5 kDa). Solid dispersions with various drug loads were prepared by lyophilization. It was found that the drug solubility in aqueous PVP solutions was significantly increased indicating the presence of drug-carrier interaction while the drug solubility was not affected by the saccharides indicating absence of drug-carrier interaction. X-ray powder diffraction and modulated differential scanning calorimetry revealed that all solid dispersions were fully amorphous. Dissolution behavior of solid dispersion tablets based on either the PVPs or saccharides was governed by both dissolution of the carrier and drug load. It was shown that a fast drug dissolution of solid dispersions with a high drug load could be obtained with carrier that showed interaction with the drug.

Authors+Show Affiliations

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands. P.srinarong@rug.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20735300

Citation

Srinarong, Parinda, et al. "Effect of Drug-carrier Interaction On the Dissolution Behavior of Solid Dispersion Tablets." Pharmaceutical Development and Technology, vol. 15, no. 5, 2010, pp. 460-8.
Srinarong P, Kouwen S, Visser MR, et al. Effect of drug-carrier interaction on the dissolution behavior of solid dispersion tablets. Pharm Dev Technol. 2010;15(5):460-8.
Srinarong, P., Kouwen, S., Visser, M. R., Hinrichs, W. L., & Frijlink, H. W. (2010). Effect of drug-carrier interaction on the dissolution behavior of solid dispersion tablets. Pharmaceutical Development and Technology, 15(5), 460-8. https://doi.org/10.3109/10837450903286529
Srinarong P, et al. Effect of Drug-carrier Interaction On the Dissolution Behavior of Solid Dispersion Tablets. Pharm Dev Technol. 2010 Sep-Oct;15(5):460-8. PubMed PMID: 20735300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of drug-carrier interaction on the dissolution behavior of solid dispersion tablets. AU - Srinarong,Parinda, AU - Kouwen,Sander, AU - Visser,Marinella R, AU - Hinrichs,Wouter L J, AU - Frijlink,Henderik W, PY - 2010/8/26/entrez PY - 2010/8/26/pubmed PY - 2010/12/14/medline SP - 460 EP - 8 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 15 IS - 5 N2 - The objective of this study was to compare the dissolution behavior of tablets prepared from solid dispersions with and without drug-carrier interactions. Diazepam and nifedipine were used as model drugs. Two types of carriers were used; polyvinylpyrrolidone (PVP K12, K30 and K60) and saccharides (inulin 1.8 kDa, 4 kDa and 6.5 kDa). Solid dispersions with various drug loads were prepared by lyophilization. It was found that the drug solubility in aqueous PVP solutions was significantly increased indicating the presence of drug-carrier interaction while the drug solubility was not affected by the saccharides indicating absence of drug-carrier interaction. X-ray powder diffraction and modulated differential scanning calorimetry revealed that all solid dispersions were fully amorphous. Dissolution behavior of solid dispersion tablets based on either the PVPs or saccharides was governed by both dissolution of the carrier and drug load. It was shown that a fast drug dissolution of solid dispersions with a high drug load could be obtained with carrier that showed interaction with the drug. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/20735300/Effect_of_drug_carrier_interaction_on_the_dissolution_behavior_of_solid_dispersion_tablets_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450903286529 DB - PRIME DP - Unbound Medicine ER -