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Resistance to tobramycin and colistin in isolates of Pseudomonas aeruginosa from chronically colonized patients with cystic fibrosis under antimicrobial treatment.
Scand J Infect Dis. 2010 Dec; 42(11-12):885-9.SJ

Abstract

Tobramycin and colistin represent 2 standard antimicrobial agents in the treatment of cystic fibrosis (CF) patients who are chronically colonized with Pseudomonas aeruginosa. In this study, we determined the rate of resistance to tobramycin and colistin in 1844 isolates of P. aeruginosa obtained from 22 CF patients under alternate therapy with inhaled tobramycin and colistin. Resistance to tobramycin was observed in 27.5% of isolates. In contrast, all isolates were susceptible to colistin. Molecular typing of selected isolates suggested that only 1 clone occurred over time in each patient. To conclude, resistance to tobramycin in P. aeruginosa isolates from CF patients under antimicrobial therapy may occur while colistin resistance remains uncommon.

Authors+Show Affiliations

Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany. gvalenza@hygiene.uni-wuerzburg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20735333

Citation

Valenza, Giuseppe, et al. "Resistance to Tobramycin and Colistin in Isolates of Pseudomonas Aeruginosa From Chronically Colonized Patients With Cystic Fibrosis Under Antimicrobial Treatment." Scandinavian Journal of Infectious Diseases, vol. 42, no. 11-12, 2010, pp. 885-9.
Valenza G, Radike K, Schoen C, et al. Resistance to tobramycin and colistin in isolates of Pseudomonas aeruginosa from chronically colonized patients with cystic fibrosis under antimicrobial treatment. Scand J Infect Dis. 2010;42(11-12):885-9.
Valenza, G., Radike, K., Schoen, C., Horn, S., Oesterlein, A., Frosch, M., Abele-Horn, M., & Hebestreit, H. (2010). Resistance to tobramycin and colistin in isolates of Pseudomonas aeruginosa from chronically colonized patients with cystic fibrosis under antimicrobial treatment. Scandinavian Journal of Infectious Diseases, 42(11-12), 885-9. https://doi.org/10.3109/00365548.2010.509333
Valenza G, et al. Resistance to Tobramycin and Colistin in Isolates of Pseudomonas Aeruginosa From Chronically Colonized Patients With Cystic Fibrosis Under Antimicrobial Treatment. Scand J Infect Dis. 2010;42(11-12):885-9. PubMed PMID: 20735333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resistance to tobramycin and colistin in isolates of Pseudomonas aeruginosa from chronically colonized patients with cystic fibrosis under antimicrobial treatment. AU - Valenza,Giuseppe, AU - Radike,Kerstin, AU - Schoen,Christoph, AU - Horn,Stephan, AU - Oesterlein,Anett, AU - Frosch,Matthias, AU - Abele-Horn,Marianne, AU - Hebestreit,Helge, Y1 - 2010/08/25/ PY - 2010/8/26/entrez PY - 2010/8/26/pubmed PY - 2011/2/26/medline SP - 885 EP - 9 JF - Scandinavian journal of infectious diseases JO - Scand J Infect Dis VL - 42 IS - 11-12 N2 - Tobramycin and colistin represent 2 standard antimicrobial agents in the treatment of cystic fibrosis (CF) patients who are chronically colonized with Pseudomonas aeruginosa. In this study, we determined the rate of resistance to tobramycin and colistin in 1844 isolates of P. aeruginosa obtained from 22 CF patients under alternate therapy with inhaled tobramycin and colistin. Resistance to tobramycin was observed in 27.5% of isolates. In contrast, all isolates were susceptible to colistin. Molecular typing of selected isolates suggested that only 1 clone occurred over time in each patient. To conclude, resistance to tobramycin in P. aeruginosa isolates from CF patients under antimicrobial therapy may occur while colistin resistance remains uncommon. SN - 1651-1980 UR - https://www.unboundmedicine.com/medline/citation/20735333/Resistance_to_tobramycin_and_colistin_in_isolates_of_Pseudomonas_aeruginosa_from_chronically_colonized_patients_with_cystic_fibrosis_under_antimicrobial_treatment_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365548.2010.509333 DB - PRIME DP - Unbound Medicine ER -