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A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children.

Abstract

Because children are becoming overweight, unhealthy, and unfit, understanding the neurocognitive benefits of an active lifestyle in childhood has important public health and educational implications. Animal research has indicated that aerobic exercise is related to increased cell proliferation and survival in the hippocampus as well as enhanced hippocampal-dependent learning and memory. Recent evidence extends this relationship to elderly humans by suggesting that high aerobic fitness levels in older adults are associated with increased hippocampal volume and superior memory performance. The present study aimed to further extend the link between fitness, hippocampal volume, and memory to a sample of preadolescent children. To this end, magnetic resonance imaging was employed to investigate whether higher- and lower-fit 9- and 10-year-old children showed differences in hippocampal volume and if the differences were related to performance on an item and relational memory task. Relational but not item memory is primarily supported by the hippocampus. Consistent with predictions, higher-fit children showed greater bilateral hippocampal volumes and superior relational memory task performance compared to lower-fit children. Hippocampal volume was also positively associated with performance on the relational but not the item memory task. Furthermore, bilateral hippocampal volume was found to mediate the relationship between fitness level (VO(2) max) and relational memory. No relationship between aerobic fitness, nucleus accumbens volume, and memory was reported, which strengthens the hypothesized specific effect of fitness on the hippocampus. The findings are the first to indicate that aerobic fitness may relate to the structure and function of the preadolescent human brain.

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    ,

    Department of Psychology & Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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    Source

    Brain research 1358: 2010 Oct 28 pg 172-83

    MeSH

    Analysis of Variance
    Association Learning
    Brain Mapping
    Calorimetry, Indirect
    Child
    Exercise
    Female
    Functional Laterality
    Hippocampus
    Humans
    Image Processing, Computer-Assisted
    Magnetic Resonance Imaging
    Male
    Memory
    Models, Biological
    Neuropsychological Tests
    Nucleus Accumbens
    Oxygen Consumption
    Statistics as Topic

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20735996

    Citation

    Chaddock, Laura, et al. "A Neuroimaging Investigation of the Association Between Aerobic Fitness, Hippocampal Volume, and Memory Performance in Preadolescent Children." Brain Research, vol. 1358, 2010, pp. 172-83.
    Chaddock L, Erickson KI, Prakash RS, et al. A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children. Brain Res. 2010;1358:172-83.
    Chaddock, L., Erickson, K. I., Prakash, R. S., Kim, J. S., Voss, M. W., Vanpatter, M., ... Kramer, A. F. (2010). A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children. Brain Research, 1358, pp. 172-83. doi:10.1016/j.brainres.2010.08.049.
    Chaddock L, et al. A Neuroimaging Investigation of the Association Between Aerobic Fitness, Hippocampal Volume, and Memory Performance in Preadolescent Children. Brain Res. 2010 Oct 28;1358:172-83. PubMed PMID: 20735996.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children. AU - Chaddock,Laura, AU - Erickson,Kirk I, AU - Prakash,Ruchika Shaurya, AU - Kim,Jennifer S, AU - Voss,Michelle W, AU - Vanpatter,Matt, AU - Pontifex,Matthew B, AU - Raine,Lauren B, AU - Konkel,Alex, AU - Hillman,Charles H, AU - Cohen,Neal J, AU - Kramer,Arthur F, Y1 - 2010/08/22/ PY - 2010/02/25/received PY - 2010/08/03/revised PY - 2010/08/17/accepted PY - 2010/8/26/entrez PY - 2010/8/26/pubmed PY - 2011/1/19/medline SP - 172 EP - 83 JF - Brain research JO - Brain Res. VL - 1358 N2 - Because children are becoming overweight, unhealthy, and unfit, understanding the neurocognitive benefits of an active lifestyle in childhood has important public health and educational implications. Animal research has indicated that aerobic exercise is related to increased cell proliferation and survival in the hippocampus as well as enhanced hippocampal-dependent learning and memory. Recent evidence extends this relationship to elderly humans by suggesting that high aerobic fitness levels in older adults are associated with increased hippocampal volume and superior memory performance. The present study aimed to further extend the link between fitness, hippocampal volume, and memory to a sample of preadolescent children. To this end, magnetic resonance imaging was employed to investigate whether higher- and lower-fit 9- and 10-year-old children showed differences in hippocampal volume and if the differences were related to performance on an item and relational memory task. Relational but not item memory is primarily supported by the hippocampus. Consistent with predictions, higher-fit children showed greater bilateral hippocampal volumes and superior relational memory task performance compared to lower-fit children. Hippocampal volume was also positively associated with performance on the relational but not the item memory task. Furthermore, bilateral hippocampal volume was found to mediate the relationship between fitness level (VO(2) max) and relational memory. No relationship between aerobic fitness, nucleus accumbens volume, and memory was reported, which strengthens the hypothesized specific effect of fitness on the hippocampus. The findings are the first to indicate that aerobic fitness may relate to the structure and function of the preadolescent human brain. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/20735996/A_neuroimaging_investigation_of_the_association_between_aerobic_fitness_hippocampal_volume_and_memory_performance_in_preadolescent_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(10)01831-7 DB - PRIME DP - Unbound Medicine ER -