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Diet, but not oral probiotics, effectively reduces urinary oxalate excretion and calcium oxalate supersaturation.
Kidney Int. 2010 Dec; 78(11):1178-85.KI

Abstract

We examined the effect of a controlled diet and two probiotic preparations on urinary oxalate excretion, a risk factor for calcium oxalate kidney stone formation, in patients with mild hyperoxaluria. Patients were randomized to a placebo, a probiotic, or a synbiotic preparation. This tested whether these probiotic preparations can increase oxalate metabolism in the intestine and/or decrease oxalate absorption from the gut. Patients were maintained on a controlled diet to remove the confounding variable of differing oxalate intake from food. Urinary oxalate excretion and calcium oxalate supersaturation on the controlled diet were significantly lower compared with baseline on a free-choice diet. Neither study preparation reduced urinary oxalate excretion nor calcium oxalate supersaturation. Fecal lactobacilli colony counts increased on both preparations, whereas enterococcal and yeast colony counts were increased on the synbiotic. Total urine volume and the excretion of oxalate and calcium were all strong independent determinants of urinary calcium oxalate supersaturation. Hence, dietary oxalate restriction reduced urinary oxalate excretion, but the tested probiotics did not influence urinary oxalate levels in patients on a restricted oxalate diet. However, this study suggests that dietary oxalate restriction is useful for kidney stone prevention.

Authors+Show Affiliations

Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. Lieske.John@mayo.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20736987

Citation

Lieske, John C., et al. "Diet, but Not Oral Probiotics, Effectively Reduces Urinary Oxalate Excretion and Calcium Oxalate Supersaturation." Kidney International, vol. 78, no. 11, 2010, pp. 1178-85.
Lieske JC, Tremaine WJ, De Simone C, et al. Diet, but not oral probiotics, effectively reduces urinary oxalate excretion and calcium oxalate supersaturation. Kidney Int. 2010;78(11):1178-85.
Lieske, J. C., Tremaine, W. J., De Simone, C., O'Connor, H. M., Li, X., Bergstralh, E. J., & Goldfarb, D. S. (2010). Diet, but not oral probiotics, effectively reduces urinary oxalate excretion and calcium oxalate supersaturation. Kidney International, 78(11), 1178-85. https://doi.org/10.1038/ki.2010.310
Lieske JC, et al. Diet, but Not Oral Probiotics, Effectively Reduces Urinary Oxalate Excretion and Calcium Oxalate Supersaturation. Kidney Int. 2010;78(11):1178-85. PubMed PMID: 20736987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet, but not oral probiotics, effectively reduces urinary oxalate excretion and calcium oxalate supersaturation. AU - Lieske,John C, AU - Tremaine,William J, AU - De Simone,Claudio, AU - O'Connor,Helen M, AU - Li,Xujian, AU - Bergstralh,Eric J, AU - Goldfarb,David S, Y1 - 2010/08/25/ PY - 2010/8/26/entrez PY - 2010/8/26/pubmed PY - 2011/2/26/medline SP - 1178 EP - 85 JF - Kidney international JO - Kidney Int VL - 78 IS - 11 N2 - We examined the effect of a controlled diet and two probiotic preparations on urinary oxalate excretion, a risk factor for calcium oxalate kidney stone formation, in patients with mild hyperoxaluria. Patients were randomized to a placebo, a probiotic, or a synbiotic preparation. This tested whether these probiotic preparations can increase oxalate metabolism in the intestine and/or decrease oxalate absorption from the gut. Patients were maintained on a controlled diet to remove the confounding variable of differing oxalate intake from food. Urinary oxalate excretion and calcium oxalate supersaturation on the controlled diet were significantly lower compared with baseline on a free-choice diet. Neither study preparation reduced urinary oxalate excretion nor calcium oxalate supersaturation. Fecal lactobacilli colony counts increased on both preparations, whereas enterococcal and yeast colony counts were increased on the synbiotic. Total urine volume and the excretion of oxalate and calcium were all strong independent determinants of urinary calcium oxalate supersaturation. Hence, dietary oxalate restriction reduced urinary oxalate excretion, but the tested probiotics did not influence urinary oxalate levels in patients on a restricted oxalate diet. However, this study suggests that dietary oxalate restriction is useful for kidney stone prevention. SN - 1523-1755 UR - https://www.unboundmedicine.com/medline/citation/20736987/Diet_but_not_oral_probiotics_effectively_reduces_urinary_oxalate_excretion_and_calcium_oxalate_supersaturation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0085-2538(15)54438-4 DB - PRIME DP - Unbound Medicine ER -