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Dynamic regulation of sarcomeric actin filaments in striated muscle.
Cytoskeleton (Hoboken). 2010 Nov; 67(11):677-92.C

Abstract

In striated muscle, the actin cytoskeleton is differentiated into myofibrils. Actin and myosin filaments are organized in sarcomeres and specialized for producing contractile forces. Regular arrangement of actin filaments with uniform length and polarity is critical for the contractile function. However, the mechanisms of assembly and maintenance of sarcomeric actin filaments in striated muscle are not completely understood. Live imaging of actin in striated muscle has revealed that actin subunits within sarcomeric actin filaments are dynamically exchanged without altering overall sarcomeric structures. A number of regulators for actin dynamics have been identified, and malfunction of these regulators often result in disorganization of myofibril structures or muscle diseases. Therefore, proper regulation of actin dynamics in striated muscle is critical for assembly and maintenance of functional myofibrils. Recent studies have suggested that both enhancers of actin dynamics and stabilizers of actin filaments are important for sarcomeric actin organization. Further investigation of the regulatory mechanism of actin dynamics in striated muscle should be a key to understanding how myofibrils develop and operate.

Authors+Show Affiliations

Department of Pathology and Department of Cell Biology, Emory University, Atlanta, Georgia 30322, USA. sono@emory.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

20737540

Citation

Ono, Shoichiro. "Dynamic Regulation of Sarcomeric Actin Filaments in Striated Muscle." Cytoskeleton (Hoboken, N.J.), vol. 67, no. 11, 2010, pp. 677-92.
Ono S. Dynamic regulation of sarcomeric actin filaments in striated muscle. Cytoskeleton (Hoboken). 2010;67(11):677-92.
Ono, S. (2010). Dynamic regulation of sarcomeric actin filaments in striated muscle. Cytoskeleton (Hoboken, N.J.), 67(11), 677-92. https://doi.org/10.1002/cm.20476
Ono S. Dynamic Regulation of Sarcomeric Actin Filaments in Striated Muscle. Cytoskeleton (Hoboken). 2010;67(11):677-92. PubMed PMID: 20737540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dynamic regulation of sarcomeric actin filaments in striated muscle. A1 - Ono,Shoichiro, PY - 2010/8/26/entrez PY - 2010/8/26/pubmed PY - 2011/1/28/medline SP - 677 EP - 92 JF - Cytoskeleton (Hoboken, N.J.) JO - Cytoskeleton (Hoboken) VL - 67 IS - 11 N2 - In striated muscle, the actin cytoskeleton is differentiated into myofibrils. Actin and myosin filaments are organized in sarcomeres and specialized for producing contractile forces. Regular arrangement of actin filaments with uniform length and polarity is critical for the contractile function. However, the mechanisms of assembly and maintenance of sarcomeric actin filaments in striated muscle are not completely understood. Live imaging of actin in striated muscle has revealed that actin subunits within sarcomeric actin filaments are dynamically exchanged without altering overall sarcomeric structures. A number of regulators for actin dynamics have been identified, and malfunction of these regulators often result in disorganization of myofibril structures or muscle diseases. Therefore, proper regulation of actin dynamics in striated muscle is critical for assembly and maintenance of functional myofibrils. Recent studies have suggested that both enhancers of actin dynamics and stabilizers of actin filaments are important for sarcomeric actin organization. Further investigation of the regulatory mechanism of actin dynamics in striated muscle should be a key to understanding how myofibrils develop and operate. SN - 1949-3592 UR - https://www.unboundmedicine.com/medline/citation/20737540/Dynamic_regulation_of_sarcomeric_actin_filaments_in_striated_muscle_ L2 - https://doi.org/10.1002/cm.20476 DB - PRIME DP - Unbound Medicine ER -