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Soil transmitted helminth infections and schistosomiasis in school age children in sub-Saharan Africa: efficacy of chemotherapeutic intervention since World Health Assembly Resolution 2001.
Tanzan J Health Res. 2010 Jan; 12(1):86-99.TJ

Abstract

Soil transmitted helminth infections (STH) and schistosomiasis constitute major public health challenges among school-age children in sub-Saharan Africa. This review assessed the efficacy of chemotherapeutic intervention in line with the World Health Assembly (WHA) resolution since the passage in 2001. Using the Medline Entrez-Pubmed search, relevant publications were identified via combinations of key words such as helminth infection, school children, chemotherapy, Africa. Albendazole, mebendazole, and praziquantel were the antihelminthic drugs most commonly evaluated. Cure rates >80% and egg reduction rates >90% were recorded in most cases of schistosomiasis using praziquantel. Albendazole was very effective against A. lumbricoides and hookworm infections with majority of the studies recording cure rates >75%, but the efficacy of the drug was poor against T. trichiura. To ensure the realization of the WHA resolution, there is need for regular treatment of school children, development of alternative antihelminthic drugs and vaccines, environmental control measures and health education.

Authors+Show Affiliations

Department of Medical Microbiology/Parasitology, Faculty of Clinical Medicine, Ebonyi State University, PMB 053 Abakaliki, Nigeria. unekecj@yahoo.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20737834

Citation

Uneke, C J.. "Soil Transmitted Helminth Infections and Schistosomiasis in School Age Children in sub-Saharan Africa: Efficacy of Chemotherapeutic Intervention Since World Health Assembly Resolution 2001." Tanzania Journal of Health Research, vol. 12, no. 1, 2010, pp. 86-99.
Uneke CJ. Soil transmitted helminth infections and schistosomiasis in school age children in sub-Saharan Africa: efficacy of chemotherapeutic intervention since World Health Assembly Resolution 2001. Tanzan J Health Res. 2010;12(1):86-99.
Uneke, C. J. (2010). Soil transmitted helminth infections and schistosomiasis in school age children in sub-Saharan Africa: efficacy of chemotherapeutic intervention since World Health Assembly Resolution 2001. Tanzania Journal of Health Research, 12(1), 86-99.
Uneke CJ. Soil Transmitted Helminth Infections and Schistosomiasis in School Age Children in sub-Saharan Africa: Efficacy of Chemotherapeutic Intervention Since World Health Assembly Resolution 2001. Tanzan J Health Res. 2010;12(1):86-99. PubMed PMID: 20737834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soil transmitted helminth infections and schistosomiasis in school age children in sub-Saharan Africa: efficacy of chemotherapeutic intervention since World Health Assembly Resolution 2001. A1 - Uneke,C J, PY - 2010/8/27/entrez PY - 2010/8/27/pubmed PY - 2010/9/10/medline SP - 86 EP - 99 JF - Tanzania journal of health research JO - Tanzan J Health Res VL - 12 IS - 1 N2 - Soil transmitted helminth infections (STH) and schistosomiasis constitute major public health challenges among school-age children in sub-Saharan Africa. This review assessed the efficacy of chemotherapeutic intervention in line with the World Health Assembly (WHA) resolution since the passage in 2001. Using the Medline Entrez-Pubmed search, relevant publications were identified via combinations of key words such as helminth infection, school children, chemotherapy, Africa. Albendazole, mebendazole, and praziquantel were the antihelminthic drugs most commonly evaluated. Cure rates >80% and egg reduction rates >90% were recorded in most cases of schistosomiasis using praziquantel. Albendazole was very effective against A. lumbricoides and hookworm infections with majority of the studies recording cure rates >75%, but the efficacy of the drug was poor against T. trichiura. To ensure the realization of the WHA resolution, there is need for regular treatment of school children, development of alternative antihelminthic drugs and vaccines, environmental control measures and health education. SN - 1821-6404 UR - https://www.unboundmedicine.com/medline/citation/20737834/Soil_transmitted_helminth_infections_and_schistosomiasis_in_school_age_children_in_sub_Saharan_Africa:_efficacy_of_chemotherapeutic_intervention_since_World_Health_Assembly_Resolution_2001_ L2 - http://www.diseaseinfosearch.org/result/6440 DB - PRIME DP - Unbound Medicine ER -