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Antioxidant activity and total phenolic content of methanol extracts of Ixora coccinea.
Pharm Biol. 2010 Oct; 48(10):1119-23.PB

Abstract

OBJECTIVE

To investigate the in vitro antioxidant activity of methanol extracts of Ixora coccinea L. (Rubiaceae) flower, leaf and stem.

MATERIALS AND METHODS

The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, total antioxidant capacity (TAC) and xanthine oxidase inhibition assay were carried out to evaluate the antioxidant potential of the extract. The IC(50) values were calculated for the DPPH and xanthine oxidase assays in order to evaluate the antioxidant efficiency of each of the I. coccinea extracts. The phenol contents were also determined.

RESULTS

I. coccinea flowers revealed the best antioxidant property, presenting much lower IC(50) value (6.6 mg/mL for DPPH assay). The flower extract showed a significantly higher antioxidant capacity compared to the other extracts. Furthermore, the highest phenolic content (polyphenols) was found in the flower extract (210.55 ± 6.31 µg GAE/mg extract). Moreover, I. coccinea extracts scavenged the superoxide radical generated by the xanthine/xanthine oxidase system. The xanthine oxidase inhibition activity was in the order of allopurinol > leaf > flower > stem with the percentage of inhibition ranged from 39.7% to 77.3% for the plant parts investigated. The highest phenolic contents (polyphenols) were found in the flower extracts (210.55 ± 6.31 µg GAE/mg extract).

CONCLUSIONS

I. coccinea could be considered as a potential source of natural antioxidant.

Authors+Show Affiliations

Department of Biotechnology, Faculty of Applied Sciences, AIMST University, Kedah.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20738154

Citation

Torey, Angeline, et al. "Antioxidant Activity and Total Phenolic Content of Methanol Extracts of Ixora Coccinea." Pharmaceutical Biology, vol. 48, no. 10, 2010, pp. 1119-23.
Torey A, Sasidharan S, Latha LY, et al. Antioxidant activity and total phenolic content of methanol extracts of Ixora coccinea. Pharm Biol. 2010;48(10):1119-23.
Torey, A., Sasidharan, S., Latha, L. Y., Sudhakaran, S., & Ramanathan, S. (2010). Antioxidant activity and total phenolic content of methanol extracts of Ixora coccinea. Pharmaceutical Biology, 48(10), 1119-23. https://doi.org/10.3109/13880200903490505
Torey A, et al. Antioxidant Activity and Total Phenolic Content of Methanol Extracts of Ixora Coccinea. Pharm Biol. 2010;48(10):1119-23. PubMed PMID: 20738154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activity and total phenolic content of methanol extracts of Ixora coccinea. AU - Torey,Angeline, AU - Sasidharan,Sreenivasan, AU - Latha,Lachimanan Yoga, AU - Sudhakaran,Sivaramakrishnan, AU - Ramanathan,Surash, PY - 2010/8/27/entrez PY - 2010/8/27/pubmed PY - 2011/1/28/medline SP - 1119 EP - 23 JF - Pharmaceutical biology JO - Pharm Biol VL - 48 IS - 10 N2 - OBJECTIVE: To investigate the in vitro antioxidant activity of methanol extracts of Ixora coccinea L. (Rubiaceae) flower, leaf and stem. MATERIALS AND METHODS: The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, total antioxidant capacity (TAC) and xanthine oxidase inhibition assay were carried out to evaluate the antioxidant potential of the extract. The IC(50) values were calculated for the DPPH and xanthine oxidase assays in order to evaluate the antioxidant efficiency of each of the I. coccinea extracts. The phenol contents were also determined. RESULTS: I. coccinea flowers revealed the best antioxidant property, presenting much lower IC(50) value (6.6 mg/mL for DPPH assay). The flower extract showed a significantly higher antioxidant capacity compared to the other extracts. Furthermore, the highest phenolic content (polyphenols) was found in the flower extract (210.55 ± 6.31 µg GAE/mg extract). Moreover, I. coccinea extracts scavenged the superoxide radical generated by the xanthine/xanthine oxidase system. The xanthine oxidase inhibition activity was in the order of allopurinol > leaf > flower > stem with the percentage of inhibition ranged from 39.7% to 77.3% for the plant parts investigated. The highest phenolic contents (polyphenols) were found in the flower extracts (210.55 ± 6.31 µg GAE/mg extract). CONCLUSIONS: I. coccinea could be considered as a potential source of natural antioxidant. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/20738154/Antioxidant_activity_and_total_phenolic_content_of_methanol_extracts_of_Ixora_coccinea_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880200903490505 DB - PRIME DP - Unbound Medicine ER -