Tags

Type your tag names separated by a space and hit enter

Beyond hereditary hemochromatosis: new insights into the relationship between iron overload and chronic liver diseases.
Dig Liver Dis. 2011 Feb; 43(2):89-95.DL

Abstract

Following the model of hereditary hemochromatosis, the possible role of iron overload as a cofactor for disease progression in acquired liver diseases has been investigated with controversial results. In recent years, progress has been made in understanding the regulation of iron metabolism, thereby allowing the evaluation of the mechanisms linking liver diseases to excessive iron accumulation. Indeed, deregulation of the transcription of hepcidin, emerging as the master regulator of systemic iron metabolism, has been implicated in the pathogenesis of hepatic iron overload in chronic liver diseases. Whatever the cause, hepatocellular iron deposition promotes liver fibrogenesis, while an emerging possible aggravating factor is represented by the strong link between iron stores and insulin resistance, a recently recognized risk factor for the progression of liver diseases. Overall, these pathogenic mechanisms, together with the known proliferative and mutagenic effect of excess iron, converge in determining an increased susceptibility to hepatocellular carcinoma. Finally, an association between serum ferritin levels and mortality in patients with end-stage liver disease has recently been reported. Prospective, randomized studies are required to evaluate whether iron depletion may reduce fibrosis progression, hepatocellular carcinoma development, and eventually mortality in patients with chronic liver diseases.

Authors+Show Affiliations

The Department of Internal Medicine, Università degli Studi, Fondazione IRCCS Ospedale Maggiore Policlinico Ca' Granda IRCCS, Milan, Italy. silvia.fargion@unimi.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20739232

Citation

Fargion, Silvia, et al. "Beyond Hereditary Hemochromatosis: New Insights Into the Relationship Between Iron Overload and Chronic Liver Diseases." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 43, no. 2, 2011, pp. 89-95.
Fargion S, Valenti L, Fracanzani AL. Beyond hereditary hemochromatosis: new insights into the relationship between iron overload and chronic liver diseases. Dig Liver Dis. 2011;43(2):89-95.
Fargion, S., Valenti, L., & Fracanzani, A. L. (2011). Beyond hereditary hemochromatosis: new insights into the relationship between iron overload and chronic liver diseases. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 43(2), 89-95. https://doi.org/10.1016/j.dld.2010.07.006
Fargion S, Valenti L, Fracanzani AL. Beyond Hereditary Hemochromatosis: New Insights Into the Relationship Between Iron Overload and Chronic Liver Diseases. Dig Liver Dis. 2011;43(2):89-95. PubMed PMID: 20739232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beyond hereditary hemochromatosis: new insights into the relationship between iron overload and chronic liver diseases. AU - Fargion,Silvia, AU - Valenti,Luca, AU - Fracanzani,Anna Ludovica, Y1 - 2010/08/24/ PY - 2010/05/14/received PY - 2010/07/22/accepted PY - 2010/8/27/entrez PY - 2010/8/27/pubmed PY - 2011/5/7/medline SP - 89 EP - 95 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 43 IS - 2 N2 - Following the model of hereditary hemochromatosis, the possible role of iron overload as a cofactor for disease progression in acquired liver diseases has been investigated with controversial results. In recent years, progress has been made in understanding the regulation of iron metabolism, thereby allowing the evaluation of the mechanisms linking liver diseases to excessive iron accumulation. Indeed, deregulation of the transcription of hepcidin, emerging as the master regulator of systemic iron metabolism, has been implicated in the pathogenesis of hepatic iron overload in chronic liver diseases. Whatever the cause, hepatocellular iron deposition promotes liver fibrogenesis, while an emerging possible aggravating factor is represented by the strong link between iron stores and insulin resistance, a recently recognized risk factor for the progression of liver diseases. Overall, these pathogenic mechanisms, together with the known proliferative and mutagenic effect of excess iron, converge in determining an increased susceptibility to hepatocellular carcinoma. Finally, an association between serum ferritin levels and mortality in patients with end-stage liver disease has recently been reported. Prospective, randomized studies are required to evaluate whether iron depletion may reduce fibrosis progression, hepatocellular carcinoma development, and eventually mortality in patients with chronic liver diseases. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/20739232/Beyond_hereditary_hemochromatosis:_new_insights_into_the_relationship_between_iron_overload_and_chronic_liver_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(10)00257-4 DB - PRIME DP - Unbound Medicine ER -