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New biologically active triterpene-saponins from Randia dumetorum.
Planta Med. 1990 Oct; 56(5):451-5.PM

Abstract

Two new triterpene-saponins, 3-O-[O-beta-D-glucopyranosyl-(1----4)-O-beta-D-glucopyranosyl-(1----3)-(beta- D-glucuronopyranosyl)]oleanolic acid (1), 3-O-[O-beta-D-glucopyranosyl-(1----6)-O-beta-D-glucopyranosyl- (1----3)-(beta-D-glucuronopyranosyl)]oleanolic acid (2) together with five known saponins (3-7) were isolated from the methanolic extract of the fruits of Randia dumetorum (Retz) Lam. (Rubiaceae). Their structures were established on the basis of chemical and spectral data. The compounds 1, 3, 4, 5 were found to enhance significantly the proliferation of human lymphocytes in vitro. The crude saponin fraction showed haemolytic, molluscicidal, and immunostimulating activities.

Authors+Show Affiliations

Dubois MA
Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Bourgogne, Dijon, France.
Benze S
No affiliation info available
Wagner H
No affiliation info available

MeSH

AnimalsBiomphalariaLymphocyte ActivationLymphocytesMolluscacidesPlants, MedicinalSaponinsTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2077549

Citation

Dubois, M A., et al. "New Biologically Active Triterpene-saponins From Randia Dumetorum." Planta Medica, vol. 56, no. 5, 1990, pp. 451-5.
Dubois MA, Benze S, Wagner H. New biologically active triterpene-saponins from Randia dumetorum. Planta Med. 1990;56(5):451-5.
Dubois, M. A., Benze, S., & Wagner, H. (1990). New biologically active triterpene-saponins from Randia dumetorum. Planta Medica, 56(5), 451-5.
Dubois MA, Benze S, Wagner H. New Biologically Active Triterpene-saponins From Randia Dumetorum. Planta Med. 1990;56(5):451-5. PubMed PMID: 2077549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New biologically active triterpene-saponins from Randia dumetorum. AU - Dubois,M A, AU - Benze,S, AU - Wagner,H, PY - 1990/10/1/pubmed PY - 1990/10/1/medline PY - 1990/10/1/entrez SP - 451 EP - 5 JF - Planta medica JO - Planta Med VL - 56 IS - 5 N2 - Two new triterpene-saponins, 3-O-[O-beta-D-glucopyranosyl-(1----4)-O-beta-D-glucopyranosyl-(1----3)-(beta- D-glucuronopyranosyl)]oleanolic acid (1), 3-O-[O-beta-D-glucopyranosyl-(1----6)-O-beta-D-glucopyranosyl- (1----3)-(beta-D-glucuronopyranosyl)]oleanolic acid (2) together with five known saponins (3-7) were isolated from the methanolic extract of the fruits of Randia dumetorum (Retz) Lam. (Rubiaceae). Their structures were established on the basis of chemical and spectral data. The compounds 1, 3, 4, 5 were found to enhance significantly the proliferation of human lymphocytes in vitro. The crude saponin fraction showed haemolytic, molluscicidal, and immunostimulating activities. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/2077549/New_biologically_active_triterpene_saponins_from_Randia_dumetorum_ DB - PRIME DP - Unbound Medicine ER -