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A primary school outbreak of pandemic 2009 influenza A (H1N1) in China.
Influenza Other Respir Viruses. 2010 Sep; 4(5):259-66.IO

Abstract

BACKGROUND

We investigated the first known outbreak of pandemic 2009 influenza A (H1N1) at a primary school in China.

OBJECTIVES

To describe epidemiologic findings, identify risk factors associated with 2009 H1N1 illness, and inform national policy including school outbreak control and surveillance strategies.

METHODS

We conducted retrospective case finding by reviewing the school's absentee log and retrieving medical records. Enhanced surveillance was implemented by requiring physicians to report any influenza-like illness (ILI) cases to public health authorities. A case-control study was conducted to detect potential risk factors for 2009 H1N1 illness. A questionnaire was administered to 50 confirmed cases and 197 age-, gender-, and location-matched controls randomly selected from student and population registries.

RESULTS

The attack rate was 4% (50/1314), and children from all grades were affected. When compared with controls, confirmed cases were more likely to have been exposed to persons with respiratory illness either in the home or classroom within 7 days of symptom onset (OR, 4.5, 95% CI: 1.9-10.7). No cases reported travel or contact with persons who had traveled outside of the country.

CONCLUSIONS

Findings in this outbreak investigation, including risk of illness associated with contacting persons with respiratory illness, are consistent with those reported by others for seasonal influenza and 2009 H1N1 outbreaks in school. The outbreak confirmed that community-level transmission of 2009 H1N1 virus was occurring in China and helped lead to changes in the national pandemic policy from containment to mitigation.

Authors+Show Affiliations

Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20795308

Citation

Huai, Yang, et al. "A Primary School Outbreak of Pandemic 2009 Influenza a (H1N1) in China." Influenza and Other Respiratory Viruses, vol. 4, no. 5, 2010, pp. 259-66.
Huai Y, Lin J, Varma JK, et al. A primary school outbreak of pandemic 2009 influenza A (H1N1) in China. Influenza Other Respir Viruses. 2010;4(5):259-66.
Huai, Y., Lin, J., Varma, J. K., Peng, Z., He, J., Cheng, C., Zhong, H., Chen, Y., Zheng, Y., Luo, Y., Liang, W., Wu, X., Huang, Z., McFarland, J., Feng, Z., Uyeki, T. M., & Yu, H. (2010). A primary school outbreak of pandemic 2009 influenza A (H1N1) in China. Influenza and Other Respiratory Viruses, 4(5), 259-66.
Huai Y, et al. A Primary School Outbreak of Pandemic 2009 Influenza a (H1N1) in China. Influenza Other Respir Viruses. 2010;4(5):259-66. PubMed PMID: 20795308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A primary school outbreak of pandemic 2009 influenza A (H1N1) in China. AU - Huai,Yang, AU - Lin,Jinyan, AU - Varma,Jay K, AU - Peng,Zhibin, AU - He,Jianfeng, AU - Cheng,Chen, AU - Zhong,Haojie, AU - Chen,Yuansheng, AU - Zheng,Yingdong, AU - Luo,Yuan, AU - Liang,Wenjia, AU - Wu,Xiaoling, AU - Huang,Zhenyu, AU - McFarland,Jeffrey, AU - Feng,Zijian, AU - Uyeki,Timothy M, AU - Yu,Hongjie, PY - 2010/8/28/entrez PY - 2010/8/28/pubmed PY - 2010/12/14/medline SP - 259 EP - 66 JF - Influenza and other respiratory viruses JO - Influenza Other Respir Viruses VL - 4 IS - 5 N2 - BACKGROUND: We investigated the first known outbreak of pandemic 2009 influenza A (H1N1) at a primary school in China. OBJECTIVES: To describe epidemiologic findings, identify risk factors associated with 2009 H1N1 illness, and inform national policy including school outbreak control and surveillance strategies. METHODS: We conducted retrospective case finding by reviewing the school's absentee log and retrieving medical records. Enhanced surveillance was implemented by requiring physicians to report any influenza-like illness (ILI) cases to public health authorities. A case-control study was conducted to detect potential risk factors for 2009 H1N1 illness. A questionnaire was administered to 50 confirmed cases and 197 age-, gender-, and location-matched controls randomly selected from student and population registries. RESULTS: The attack rate was 4% (50/1314), and children from all grades were affected. When compared with controls, confirmed cases were more likely to have been exposed to persons with respiratory illness either in the home or classroom within 7 days of symptom onset (OR, 4.5, 95% CI: 1.9-10.7). No cases reported travel or contact with persons who had traveled outside of the country. CONCLUSIONS: Findings in this outbreak investigation, including risk of illness associated with contacting persons with respiratory illness, are consistent with those reported by others for seasonal influenza and 2009 H1N1 outbreaks in school. The outbreak confirmed that community-level transmission of 2009 H1N1 virus was occurring in China and helped lead to changes in the national pandemic policy from containment to mitigation. SN - 1750-2659 UR - https://www.unboundmedicine.com/medline/citation/20795308/A_primary_school_outbreak_of_pandemic_2009_influenza_A__H1N1__in_China_ L2 - https://doi.org/10.1111/j.1750-2659.2010.00150.x DB - PRIME DP - Unbound Medicine ER -