Tags

Type your tag names separated by a space and hit enter

Hydroalcoholic extract of Emblica officinalis Gaertn. affords protection against PTZ-induced seizures, oxidative stress and cognitive impairment in rats.
Indian J Exp Biol. 2010 May; 48(5):474-8.IJ

Abstract

The cognitive impairment seen in epileptics may be a consequence of either the underlying epileptogenic process alone or it could manifest on account of the use of antiepileptic drugs that cause cognitive impairment as an adverse effect or both. Thus, there is a need for drugs that can suppress epileptogenesis without contributing to or, if possible, by acting to prevent the development of cognitive impairment. Emblica officinalis, an Indian medicinal plant, has marked antioxidant property. The effect of seven days pretreatment of 300, 500 and 700 mg/kg doses of hydroalcoholic extract of E. officinalis (HAEEO) administered intraperitoneally to rats was evaluated on pentylenetetrazole (PTZ) induced seizures, cognitive deficit and oxidative stress markers viz malondialdehyde (MDA) and glutathione. The 500 and 700 mg/kg ip doses of HAEEO completely abolished the generalized tonic seizures and also improved the retention latency in passive avoidance task. Further, HAEEO dose-dependently ameliorated the oxidative stress induced by PTZ. These findings suggest the potential of HAEEO to be used as an adjuvant to treatment with antiepileptic drugs.

Authors+Show Affiliations

Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20795364

Citation

Golechha, Mahaveer, et al. "Hydroalcoholic Extract of Emblica Officinalis Gaertn. Affords Protection Against PTZ-induced Seizures, Oxidative Stress and Cognitive Impairment in Rats." Indian Journal of Experimental Biology, vol. 48, no. 5, 2010, pp. 474-8.
Golechha M, Bhatia J, Arya DS. Hydroalcoholic extract of Emblica officinalis Gaertn. affords protection against PTZ-induced seizures, oxidative stress and cognitive impairment in rats. Indian J Exp Biol. 2010;48(5):474-8.
Golechha, M., Bhatia, J., & Arya, D. S. (2010). Hydroalcoholic extract of Emblica officinalis Gaertn. affords protection against PTZ-induced seizures, oxidative stress and cognitive impairment in rats. Indian Journal of Experimental Biology, 48(5), 474-8.
Golechha M, Bhatia J, Arya DS. Hydroalcoholic Extract of Emblica Officinalis Gaertn. Affords Protection Against PTZ-induced Seizures, Oxidative Stress and Cognitive Impairment in Rats. Indian J Exp Biol. 2010;48(5):474-8. PubMed PMID: 20795364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydroalcoholic extract of Emblica officinalis Gaertn. affords protection against PTZ-induced seizures, oxidative stress and cognitive impairment in rats. AU - Golechha,Mahaveer, AU - Bhatia,Jagriti, AU - Arya,Dharamvir Singh, PY - 2010/8/28/entrez PY - 2010/8/28/pubmed PY - 2010/10/6/medline SP - 474 EP - 8 JF - Indian journal of experimental biology JO - Indian J Exp Biol VL - 48 IS - 5 N2 - The cognitive impairment seen in epileptics may be a consequence of either the underlying epileptogenic process alone or it could manifest on account of the use of antiepileptic drugs that cause cognitive impairment as an adverse effect or both. Thus, there is a need for drugs that can suppress epileptogenesis without contributing to or, if possible, by acting to prevent the development of cognitive impairment. Emblica officinalis, an Indian medicinal plant, has marked antioxidant property. The effect of seven days pretreatment of 300, 500 and 700 mg/kg doses of hydroalcoholic extract of E. officinalis (HAEEO) administered intraperitoneally to rats was evaluated on pentylenetetrazole (PTZ) induced seizures, cognitive deficit and oxidative stress markers viz malondialdehyde (MDA) and glutathione. The 500 and 700 mg/kg ip doses of HAEEO completely abolished the generalized tonic seizures and also improved the retention latency in passive avoidance task. Further, HAEEO dose-dependently ameliorated the oxidative stress induced by PTZ. These findings suggest the potential of HAEEO to be used as an adjuvant to treatment with antiepileptic drugs. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/20795364/Hydroalcoholic_extract_of_Emblica_officinalis_Gaertn__affords_protection_against_PTZ_induced_seizures_oxidative_stress_and_cognitive_impairment_in_rats_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -