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Chemical composition and antibacterial activity of essential oils of Tripleurospermum disciforme in three developmental stages.
Pharm Biol. 2010 Nov; 48(11):1280-4.PB

Abstract

CONTEXT

Tripleurospermum disciforme (C.A. Mey) Schultz Bip. (Asteraceae) is a widespread biennial species which also has traditional medicinal uses. According to the few recent studies, essential oils of this species exhibit anti-inflammatory, antispasmodic, antiseptic, antifungal, antiulcer, and antioxidant activity.

OBJECTIVE

The chemical compositions of the hydrodistilled oils of T. disciforme of Iranian origin are studied in the stages of prior to flowering, flowering, and post flowering, for the first time. Also, we investigated the antibacterial activities of the oils.

MATERIALS AND METHODS

The essential oils of air-dried T. disciforme were obtained by hydrodistillation in three different developmental stages and analyzed by gas chromatography-mass spectrometry (GC-MS). The antimicrobial activity of the isolated essential oil, in the three stages, was also investigated against four Gram-positive and four Gram-negative bacteria.

RESULTS

Twenty-one components were identified in the essential oils of T. disciforme, and the highest amount of oil was extracted at the flowering stage. The main component of the species in the flowering stage was β-farnesene (22.46%) and the other major components were β-sesquiphellandrene (17.85%), p-methoxy-β-cyclopropylstyrene (16.64%), heptadecane (10.6%), p-methoxy-humulene oxide (6.88%) and benzene acetaldehyde (9.3%). The MIC of essential oil was evaluated from 4 µL ml(-1) against Staphylococcus subtilis and Bacillus cereus to 22 µL ml(-1) against Citrobacter amalonaticus.

DISCUSSION AND CONCLUSION

This study demonstrates the occurrence of β-farnesene/β-sesquiphellandrene chemotype of T. disciforme in western regions of Iran that are different from previous reports. The findings also showed that the essential oils T. disciforme have excellent antibacterial activities and thus have great potentiality to be used as a resource for natural health products.

Authors+Show Affiliations

Laboratory of Plant Cell Biology, Department of Biology, Bu-Ali Sina University, Hamedan, I.R. Iran. chehregani@basu.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20795784

Citation

Chehregani, Abdolkarim, et al. "Chemical Composition and Antibacterial Activity of Essential Oils of Tripleurospermum Disciforme in Three Developmental Stages." Pharmaceutical Biology, vol. 48, no. 11, 2010, pp. 1280-4.
Chehregani A, Mohsenzadeh F, Mirazi N, et al. Chemical composition and antibacterial activity of essential oils of Tripleurospermum disciforme in three developmental stages. Pharm Biol. 2010;48(11):1280-4.
Chehregani, A., Mohsenzadeh, F., Mirazi, N., Hajisadeghian, S., & Baghali, Z. (2010). Chemical composition and antibacterial activity of essential oils of Tripleurospermum disciforme in three developmental stages. Pharmaceutical Biology, 48(11), 1280-4. https://doi.org/10.3109/13880201003770143
Chehregani A, et al. Chemical Composition and Antibacterial Activity of Essential Oils of Tripleurospermum Disciforme in Three Developmental Stages. Pharm Biol. 2010;48(11):1280-4. PubMed PMID: 20795784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition and antibacterial activity of essential oils of Tripleurospermum disciforme in three developmental stages. AU - Chehregani,Abdolkarim, AU - Mohsenzadeh,Fariba, AU - Mirazi,Naser, AU - Hajisadeghian,Somayeh, AU - Baghali,Zahra, Y1 - 2010/08/26/ PY - 2010/8/28/entrez PY - 2010/8/28/pubmed PY - 2011/3/9/medline SP - 1280 EP - 4 JF - Pharmaceutical biology JO - Pharm Biol VL - 48 IS - 11 N2 - CONTEXT: Tripleurospermum disciforme (C.A. Mey) Schultz Bip. (Asteraceae) is a widespread biennial species which also has traditional medicinal uses. According to the few recent studies, essential oils of this species exhibit anti-inflammatory, antispasmodic, antiseptic, antifungal, antiulcer, and antioxidant activity. OBJECTIVE: The chemical compositions of the hydrodistilled oils of T. disciforme of Iranian origin are studied in the stages of prior to flowering, flowering, and post flowering, for the first time. Also, we investigated the antibacterial activities of the oils. MATERIALS AND METHODS: The essential oils of air-dried T. disciforme were obtained by hydrodistillation in three different developmental stages and analyzed by gas chromatography-mass spectrometry (GC-MS). The antimicrobial activity of the isolated essential oil, in the three stages, was also investigated against four Gram-positive and four Gram-negative bacteria. RESULTS: Twenty-one components were identified in the essential oils of T. disciforme, and the highest amount of oil was extracted at the flowering stage. The main component of the species in the flowering stage was β-farnesene (22.46%) and the other major components were β-sesquiphellandrene (17.85%), p-methoxy-β-cyclopropylstyrene (16.64%), heptadecane (10.6%), p-methoxy-humulene oxide (6.88%) and benzene acetaldehyde (9.3%). The MIC of essential oil was evaluated from 4 µL ml(-1) against Staphylococcus subtilis and Bacillus cereus to 22 µL ml(-1) against Citrobacter amalonaticus. DISCUSSION AND CONCLUSION: This study demonstrates the occurrence of β-farnesene/β-sesquiphellandrene chemotype of T. disciforme in western regions of Iran that are different from previous reports. The findings also showed that the essential oils T. disciforme have excellent antibacterial activities and thus have great potentiality to be used as a resource for natural health products. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/20795784/Chemical_composition_and_antibacterial_activity_of_essential_oils_of_Tripleurospermum_disciforme_in_three_developmental_stages_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880201003770143 DB - PRIME DP - Unbound Medicine ER -