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Vitamin D in chronic kidney disease: new potential for intervention.
Curr Drug Targets. 2011 Jan; 12(1):42-53.CD

Abstract

Prevention of progressive renal function loss and its complications remains the main challenge in clinical nephrology. Although current therapeutic strategies aiming at reduction of blood pressure and proteinuria often slow down deterioration of renal function, still many patients progress to end-stage renal disease. The development of novel pharmacological approaches for treatment of chronic kidney disease (CKD) is therefore instrumental. Here we review the renoprotective potential of vitamin D and its analogues. In CKD patients, vitamin D deficiency is common and progression of CKD is associated with low (active) vitamin D levels. Moreover, in animal models of CKD, treatment with vitamin D (analogues) alone or in combination with renin-angiotensin-aldosterone system (RAAS) blockade reduces proteinuria, glomerulosclerosis and tubulointerstitial fibrosis. Potential underlying mechanisms include suppression of the RAAS, modulation of immune cell function and direct protective effects on renal cells such as podocytes. Whether vitamin D analogues could further optimize existing therapies in human renal disease is currently under investigation.

Authors+Show Affiliations

Department of Internal Medicine, University Medical Center Groningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20795938

Citation

Mirković, Katarina, et al. "Vitamin D in Chronic Kidney Disease: New Potential for Intervention." Current Drug Targets, vol. 12, no. 1, 2011, pp. 42-53.
Mirković K, van den Born J, Navis G, et al. Vitamin D in chronic kidney disease: new potential for intervention. Curr Drug Targets. 2011;12(1):42-53.
Mirković, K., van den Born, J., Navis, G., & de Borst, M. H. (2011). Vitamin D in chronic kidney disease: new potential for intervention. Current Drug Targets, 12(1), 42-53.
Mirković K, et al. Vitamin D in Chronic Kidney Disease: New Potential for Intervention. Curr Drug Targets. 2011;12(1):42-53. PubMed PMID: 20795938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D in chronic kidney disease: new potential for intervention. AU - Mirković,Katarina, AU - van den Born,Jaap, AU - Navis,Gerjan, AU - de Borst,Martin H, PY - 2010/04/15/received PY - 2010/06/21/accepted PY - 2010/8/28/entrez PY - 2010/8/28/pubmed PY - 2011/3/31/medline SP - 42 EP - 53 JF - Current drug targets JO - Curr Drug Targets VL - 12 IS - 1 N2 - Prevention of progressive renal function loss and its complications remains the main challenge in clinical nephrology. Although current therapeutic strategies aiming at reduction of blood pressure and proteinuria often slow down deterioration of renal function, still many patients progress to end-stage renal disease. The development of novel pharmacological approaches for treatment of chronic kidney disease (CKD) is therefore instrumental. Here we review the renoprotective potential of vitamin D and its analogues. In CKD patients, vitamin D deficiency is common and progression of CKD is associated with low (active) vitamin D levels. Moreover, in animal models of CKD, treatment with vitamin D (analogues) alone or in combination with renin-angiotensin-aldosterone system (RAAS) blockade reduces proteinuria, glomerulosclerosis and tubulointerstitial fibrosis. Potential underlying mechanisms include suppression of the RAAS, modulation of immune cell function and direct protective effects on renal cells such as podocytes. Whether vitamin D analogues could further optimize existing therapies in human renal disease is currently under investigation. SN - 1873-5592 UR - https://www.unboundmedicine.com/medline/citation/20795938/Vitamin_D_in_chronic_kidney_disease:_new_potential_for_intervention_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1389-4501&volume=12&issue=1&spage=42&aulast=Mirković DB - PRIME DP - Unbound Medicine ER -