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Anti-inflammatory and anticancer compounds isolated from Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.
J Pharm Pharmacol. 2010 Sep; 62(9):1158-66.JP

Abstract

OBJECTIVES

The aim was to search for anti-inflammatory and anticancer compounds from three medicinal plants, viz. Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.

METHODS

The NO* scavenging potential of selected plant extracts was determined on LPS/IFN-gamma activated murine peritoneal macrophage cultures, and iNOS and COX-2 expression was evaluated by Western blot analysis. Bio-assay guided fractionation yielded four compounds: physcion and emodin from V. madraspatana, 1-hydroxytectoquinone from R. cordifolia, and oleanonic acid from L. camara. The anti-inflammatory activity of these compounds was tested through the carrageenan-induced rat-paw oedema model. They were then tested against a murine tumour (Ehrlich ascites carcinoma), and three human cancer cell lines, namely A375 (malignant skin melanoma), Hep2 (epidermoid laryngeal carcinoma) and U937 (lymphoma).

KEY FINDINGS

All four compounds dose dependently inhibited NO* through suppression of iNOS protein without affecting macrophage viability. Physcion and emodin caused 65-68% reduction of oedema volume at 40 mg/kg, which validated their in-vivo anti-inflammatory effect. 1-Hydroxytectoquinone and oleanonic acid exhibited promising cytotoxicity against A375 cells.

CONCLUSIONS

Ethnomedical reports on these traditional medicinal plants have been rationalised through an insight into the anti-inflammatory as well as anticancer potential of four constituents, characterised to be prospective candidates for designing novel therapeutic agents.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20796195

Citation

Ghosh, Subhalakshmi, et al. "Anti-inflammatory and Anticancer Compounds Isolated From Ventilago Madraspatana Gaertn., Rubia Cordifolia Linn. and Lantana Camara Linn." The Journal of Pharmacy and Pharmacology, vol. 62, no. 9, 2010, pp. 1158-66.
Ghosh S, Das Sarma M, Patra A, et al. Anti-inflammatory and anticancer compounds isolated from Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn. J Pharm Pharmacol. 2010;62(9):1158-66.
Ghosh, S., Das Sarma, M., Patra, A., & Hazra, B. (2010). Anti-inflammatory and anticancer compounds isolated from Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn. The Journal of Pharmacy and Pharmacology, 62(9), 1158-66. https://doi.org/10.1111/j.2042-7158.2010.01151.x
Ghosh S, et al. Anti-inflammatory and Anticancer Compounds Isolated From Ventilago Madraspatana Gaertn., Rubia Cordifolia Linn. and Lantana Camara Linn. J Pharm Pharmacol. 2010;62(9):1158-66. PubMed PMID: 20796195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and anticancer compounds isolated from Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn. AU - Ghosh,Subhalakshmi, AU - Das Sarma,Madhushree, AU - Patra,Amarendra, AU - Hazra,Banasri, PY - 2010/8/28/entrez PY - 2010/8/28/pubmed PY - 2011/3/4/medline SP - 1158 EP - 66 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 62 IS - 9 N2 - OBJECTIVES: The aim was to search for anti-inflammatory and anticancer compounds from three medicinal plants, viz. Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn. METHODS: The NO* scavenging potential of selected plant extracts was determined on LPS/IFN-gamma activated murine peritoneal macrophage cultures, and iNOS and COX-2 expression was evaluated by Western blot analysis. Bio-assay guided fractionation yielded four compounds: physcion and emodin from V. madraspatana, 1-hydroxytectoquinone from R. cordifolia, and oleanonic acid from L. camara. The anti-inflammatory activity of these compounds was tested through the carrageenan-induced rat-paw oedema model. They were then tested against a murine tumour (Ehrlich ascites carcinoma), and three human cancer cell lines, namely A375 (malignant skin melanoma), Hep2 (epidermoid laryngeal carcinoma) and U937 (lymphoma). KEY FINDINGS: All four compounds dose dependently inhibited NO* through suppression of iNOS protein without affecting macrophage viability. Physcion and emodin caused 65-68% reduction of oedema volume at 40 mg/kg, which validated their in-vivo anti-inflammatory effect. 1-Hydroxytectoquinone and oleanonic acid exhibited promising cytotoxicity against A375 cells. CONCLUSIONS: Ethnomedical reports on these traditional medicinal plants have been rationalised through an insight into the anti-inflammatory as well as anticancer potential of four constituents, characterised to be prospective candidates for designing novel therapeutic agents. SN - 2042-7158 UR - https://www.unboundmedicine.com/medline/citation/20796195/Anti_inflammatory_and_anticancer_compounds_isolated_from_Ventilago_madraspatana_Gaertn__Rubia_cordifolia_Linn__and_Lantana_camara_Linn_ L2 - https://doi.org/10.1111/j.2042-7158.2010.01151.x DB - PRIME DP - Unbound Medicine ER -