Tags

Type your tag names separated by a space and hit enter

[Protective antithrombotic effects of proline-containing peptides in the animal body subjected to stress].
Izv Akad Nauk Ser Biol. 2010 Jul-AugIA

Abstract

We discovered that simple proline-containing peptides Gly-Pro, Pro-Gly, Pro-Gly-Pro, and semax had an antistress protective effect on the organism appearing as anticoagulation system activation. Repeated intranasal injection of each of these peptides to rats prior to acute immobilization stress prevented a hypercoagulation response to prolonged stress lasting 60 min. At the same time there was increase of antithrombotic, anticoagulant, and fibrin depolymerization activity and recovery of enzymatic fibrinolytic activity. Dipeptides were found to have the greatest antistress effect. Our results showed that semax had a protective effect against enhanced blood coagulability resulting from repeated immobilization stress.

Authors

Liapina LA
No affiliation info available
Grigor'eva ME
No affiliation info available
Andreeva LA
No affiliation info available
Miasoedov NF
No affiliation info available

MeSH

Adrenocorticotropic HormoneAnimalsDipeptidesFibrinolytic AgentsImmobilizationMaleOligopeptidesPeptide FragmentsProlineRatsStress, Psychological

Pub Type(s)

Journal Article

Language

rus

PubMed ID

20799647

Citation

Liapina, L A., et al. "[Protective Antithrombotic Effects of Proline-containing Peptides in the Animal Body Subjected to Stress]." Izvestiia Akademii Nauk. Seriia Biologicheskaia, 2010, pp. 462-7.
Liapina LA, Grigor'eva ME, Andreeva LA, et al. [Protective antithrombotic effects of proline-containing peptides in the animal body subjected to stress]. Izv Akad Nauk Ser Biol. 2010.
Liapina, L. A., Grigor'eva, M. E., Andreeva, L. A., & Miasoedov, N. F. (2010). [Protective antithrombotic effects of proline-containing peptides in the animal body subjected to stress]. Izvestiia Akademii Nauk. Seriia Biologicheskaia, (4), 462-7.
Liapina LA, et al. [Protective Antithrombotic Effects of Proline-containing Peptides in the Animal Body Subjected to Stress]. Izv Akad Nauk Ser Biol. 2010 Jul-Aug;(4)462-7. PubMed PMID: 20799647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Protective antithrombotic effects of proline-containing peptides in the animal body subjected to stress]. AU - Liapina,L A, AU - Grigor'eva,M E, AU - Andreeva,L A, AU - Miasoedov,N F, PY - 2010/8/31/entrez PY - 2010/8/31/pubmed PY - 2010/10/26/medline SP - 462 EP - 7 JF - Izvestiia Akademii nauk. Seriia biologicheskaia JO - Izv Akad Nauk Ser Biol IS - 4 N2 - We discovered that simple proline-containing peptides Gly-Pro, Pro-Gly, Pro-Gly-Pro, and semax had an antistress protective effect on the organism appearing as anticoagulation system activation. Repeated intranasal injection of each of these peptides to rats prior to acute immobilization stress prevented a hypercoagulation response to prolonged stress lasting 60 min. At the same time there was increase of antithrombotic, anticoagulant, and fibrin depolymerization activity and recovery of enzymatic fibrinolytic activity. Dipeptides were found to have the greatest antistress effect. Our results showed that semax had a protective effect against enhanced blood coagulability resulting from repeated immobilization stress. SN - 1026-3470 UR - https://www.unboundmedicine.com/medline/citation/20799647/[Protective_antithrombotic_effects_of_proline_containing_peptides_in_the_animal_body_subjected_to_stress]_ DB - PRIME DP - Unbound Medicine ER -