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Mechanosensitivity during lower extremity neurodynamic testing is diminished in individuals with Type 2 Diabetes Mellitus and peripheral neuropathy: a cross sectional study.
BMC Neurol 2010; 10:75BN

Abstract

BACKGROUND

Type 2 Diabetes Mellitus (T2DM) and diabetic symmetrical polyneuropathy (DSP) impact multiple modalities of sensation including light touch, temperature, position sense and vibration perception. No study to date has examined the mechanosensitivity of peripheral nerves during limb movement in this population. The objective was to determine the unique effects T2DM and DSP have on nerve mechanosensitivity in the lower extremity.

METHODS

This cross-sectional study included 43 people with T2DM. Straight leg raise neurodynamic tests were performed with ankle plantar flexion (PF/SLR) and dorsiflexion (DF/SLR). Hip flexion range of motion (ROM), lower extremity muscle activity and symptom profile, intensity and location were measured at rest, first onset of symptoms (P1) and maximally tolerated symptoms (P2).

RESULTS

The addition of ankle dorsiflexion during SLR testing reduced the hip flexion ROM by 4.3° ± 6.5° at P1 and by 5.4° ± 4.9° at P2. Individuals in the T2DM group with signs of severe DSP (n = 9) had no difference in hip flexion ROM between PF/SLR and DF/SLR at P1 (1.4° ± 4.2°; paired t-test p = 0.34) or P2 (0.9° ± 2.5°; paired t-test p = 0.31). Movement induced muscle activity was absent during SLR with the exception of the tibialis anterior during DF/SLR testing. Increases in symptom intensity during SLR testing were similar for both PF/SLR and DF/SLR. The addition of ankle dorsiflexion induced more frequent posterior leg symptoms when taken to P2.

CONCLUSIONS

Consistent with previous recommendations in the literature, P1 is an appropriate test end point for SLR neurodynamic testing in people with T2DM. However, our findings suggest that people with T2DM and severe DSP have limited responses to SLR neurodynamic testing, and thus may be at risk for harm from nerve overstretch and the information gathered will be of limited clinical value.

Authors+Show Affiliations

Physical Therapy, University of California, San Francisco, Graduate Program in Physical Therapy, 1318 7th Avenue, Box 0736, San Francisco, CA 94143-0736, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20799983

Citation

Boyd, Benjamin S., et al. "Mechanosensitivity During Lower Extremity Neurodynamic Testing Is Diminished in Individuals With Type 2 Diabetes Mellitus and Peripheral Neuropathy: a Cross Sectional Study." BMC Neurology, vol. 10, 2010, p. 75.
Boyd BS, Wanek L, Gray AT, et al. Mechanosensitivity during lower extremity neurodynamic testing is diminished in individuals with Type 2 Diabetes Mellitus and peripheral neuropathy: a cross sectional study. BMC Neurol. 2010;10:75.
Boyd, B. S., Wanek, L., Gray, A. T., & Topp, K. S. (2010). Mechanosensitivity during lower extremity neurodynamic testing is diminished in individuals with Type 2 Diabetes Mellitus and peripheral neuropathy: a cross sectional study. BMC Neurology, 10, p. 75. doi:10.1186/1471-2377-10-75.
Boyd BS, et al. Mechanosensitivity During Lower Extremity Neurodynamic Testing Is Diminished in Individuals With Type 2 Diabetes Mellitus and Peripheral Neuropathy: a Cross Sectional Study. BMC Neurol. 2010 Aug 28;10:75. PubMed PMID: 20799983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanosensitivity during lower extremity neurodynamic testing is diminished in individuals with Type 2 Diabetes Mellitus and peripheral neuropathy: a cross sectional study. AU - Boyd,Benjamin S, AU - Wanek,Linda, AU - Gray,Andrew T, AU - Topp,Kimberly S, Y1 - 2010/08/28/ PY - 2009/11/21/received PY - 2010/08/28/accepted PY - 2010/8/31/entrez PY - 2010/8/31/pubmed PY - 2011/1/7/medline SP - 75 EP - 75 JF - BMC neurology JO - BMC Neurol VL - 10 N2 - BACKGROUND: Type 2 Diabetes Mellitus (T2DM) and diabetic symmetrical polyneuropathy (DSP) impact multiple modalities of sensation including light touch, temperature, position sense and vibration perception. No study to date has examined the mechanosensitivity of peripheral nerves during limb movement in this population. The objective was to determine the unique effects T2DM and DSP have on nerve mechanosensitivity in the lower extremity. METHODS: This cross-sectional study included 43 people with T2DM. Straight leg raise neurodynamic tests were performed with ankle plantar flexion (PF/SLR) and dorsiflexion (DF/SLR). Hip flexion range of motion (ROM), lower extremity muscle activity and symptom profile, intensity and location were measured at rest, first onset of symptoms (P1) and maximally tolerated symptoms (P2). RESULTS: The addition of ankle dorsiflexion during SLR testing reduced the hip flexion ROM by 4.3° ± 6.5° at P1 and by 5.4° ± 4.9° at P2. Individuals in the T2DM group with signs of severe DSP (n = 9) had no difference in hip flexion ROM between PF/SLR and DF/SLR at P1 (1.4° ± 4.2°; paired t-test p = 0.34) or P2 (0.9° ± 2.5°; paired t-test p = 0.31). Movement induced muscle activity was absent during SLR with the exception of the tibialis anterior during DF/SLR testing. Increases in symptom intensity during SLR testing were similar for both PF/SLR and DF/SLR. The addition of ankle dorsiflexion induced more frequent posterior leg symptoms when taken to P2. CONCLUSIONS: Consistent with previous recommendations in the literature, P1 is an appropriate test end point for SLR neurodynamic testing in people with T2DM. However, our findings suggest that people with T2DM and severe DSP have limited responses to SLR neurodynamic testing, and thus may be at risk for harm from nerve overstretch and the information gathered will be of limited clinical value. SN - 1471-2377 UR - https://www.unboundmedicine.com/medline/citation/20799983/Mechanosensitivity_during_lower_extremity_neurodynamic_testing_is_diminished_in_individuals_with_Type_2_Diabetes_Mellitus_and_peripheral_neuropathy:_a_cross_sectional_study_ L2 - https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-10-75 DB - PRIME DP - Unbound Medicine ER -