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Parathelypteriside attenuates cognition deficits in d-galactose treated mice by increasing antioxidant capacity and improving long-term potentiation.
Neurobiol Learn Mem. 2010 Oct; 94(3):414-21.NL

Abstract

Parathelypteriside (PG), a stilbenoid compound, was extracted from Parathelypteris glanduligera (kze.) ching that exhibits antioxidative and anti-inflammatory effects. The aim of this study was to investigate the protective effect of PG against the d-galactose (d-gal)-induced neurotoxicity in mice. It was found that long-term intraperitoneal (i.p.) injection of PG (5 or 10 mg/(kg day)) for two weeks significantly improved the behavioral performance of d-gal-treated mice in both Morris water maze test and step-down avoidance test. Biochemical examination revealed that PG reduced the increased levels of malondialdehyde (MDA), and attenuated the decreased activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase in the hippocampus of d-gal-treated mice. Furthermore, the electrophysiological assay showed that PG significantly rescued the long-term potentiation (LTP) impairment in mice hippocampus, and western blotting analysis indicated that the effects of PG on LTP might be attributed to the activation of cAMP-response element-binding protein (CREB). Together, these results suggested that the natural product PG represented a potential source of medicine for the treatment of the neurodegenerative diseases.

Authors+Show Affiliations

Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation of Hubei Province, College of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20800101

Citation

Fu, Wei, et al. "Parathelypteriside Attenuates Cognition Deficits in D-galactose Treated Mice By Increasing Antioxidant Capacity and Improving Long-term Potentiation." Neurobiology of Learning and Memory, vol. 94, no. 3, 2010, pp. 414-21.
Fu W, Lei YF, Chen JL, et al. Parathelypteriside attenuates cognition deficits in d-galactose treated mice by increasing antioxidant capacity and improving long-term potentiation. Neurobiol Learn Mem. 2010;94(3):414-21.
Fu, W., Lei, Y. F., Chen, J. L., Xiong, C. M., Zhou, D. N., Wu, G. H., Chen, J., Cai, Y. L., & Ruan, J. L. (2010). Parathelypteriside attenuates cognition deficits in d-galactose treated mice by increasing antioxidant capacity and improving long-term potentiation. Neurobiology of Learning and Memory, 94(3), 414-21. https://doi.org/10.1016/j.nlm.2010.08.009
Fu W, et al. Parathelypteriside Attenuates Cognition Deficits in D-galactose Treated Mice By Increasing Antioxidant Capacity and Improving Long-term Potentiation. Neurobiol Learn Mem. 2010;94(3):414-21. PubMed PMID: 20800101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parathelypteriside attenuates cognition deficits in d-galactose treated mice by increasing antioxidant capacity and improving long-term potentiation. AU - Fu,Wei, AU - Lei,Yong-Fang, AU - Chen,Jing-Lou, AU - Xiong,Chao-Mei, AU - Zhou,Dao-Nian, AU - Wu,Guang-Hua, AU - Chen,Jing, AU - Cai,Ya-Ling, AU - Ruan,Jin-Lan, Y1 - 2010/08/25/ PY - 2010/05/02/received PY - 2010/08/18/revised PY - 2010/08/19/accepted PY - 2010/8/31/entrez PY - 2010/8/31/pubmed PY - 2011/1/29/medline SP - 414 EP - 21 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 94 IS - 3 N2 - Parathelypteriside (PG), a stilbenoid compound, was extracted from Parathelypteris glanduligera (kze.) ching that exhibits antioxidative and anti-inflammatory effects. The aim of this study was to investigate the protective effect of PG against the d-galactose (d-gal)-induced neurotoxicity in mice. It was found that long-term intraperitoneal (i.p.) injection of PG (5 or 10 mg/(kg day)) for two weeks significantly improved the behavioral performance of d-gal-treated mice in both Morris water maze test and step-down avoidance test. Biochemical examination revealed that PG reduced the increased levels of malondialdehyde (MDA), and attenuated the decreased activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase in the hippocampus of d-gal-treated mice. Furthermore, the electrophysiological assay showed that PG significantly rescued the long-term potentiation (LTP) impairment in mice hippocampus, and western blotting analysis indicated that the effects of PG on LTP might be attributed to the activation of cAMP-response element-binding protein (CREB). Together, these results suggested that the natural product PG represented a potential source of medicine for the treatment of the neurodegenerative diseases. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/20800101/Parathelypteriside_attenuates_cognition_deficits_in_d_galactose_treated_mice_by_increasing_antioxidant_capacity_and_improving_long_term_potentiation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(10)00135-8 DB - PRIME DP - Unbound Medicine ER -