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Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria.

Abstract

Polycystic ovary syndrome (PCOS) is strongly associated with metabolic abnormalities in Western women. However, data from other populations and geographical regions are scarce. This study evaluated cardiovascular and metabolic risk factors in Chinese infertile women diagnosed with PCOS using the 2003 Rotterdam consensus criteria. A total of 615 women representing the four PCOS phenotypes (oligo- or anovulation (AO)+hyperandrogenism (HA)+polycystic ovaries (PCO), AO+HA, AO+PCO and HA+PCO) underwent standardized metabolic screening including a 75g oral glucose tolerance test. All groups presented with similar reproductive characteristics, with the only difference being a significantly higher Ferriman-Gallwey score for hirsutism (P=0.01) in the subgroup characterized by HA+PCO. Overall, the prevalence of metabolic syndrome was 6.4%, with no difference among the four groups (range of 2.3-12.2%). Metabolic syndrome was associated with body mass index (P<0.001), waist/hip ratio (P=0.002), index of insulin resistance (P=0.005) and fasting insulin (P=0.009) in multivariate analysis. Compared with Caucasians and Chinese women in Westernized societies, mainland Chinese women with PCOS have a low risk of metabolic syndrome and its presence does not vary across the specific PCOS phenotypes.

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  • Authors+Show Affiliations

    ,

    Department of Reproductive Medicine and Gynecology, University Medical Center, Utrecht, The Netherlands.

    , , , , , ,

    Source

    Reproductive biomedicine online 21:4 2010 Oct pg 572-80

    MeSH

    Adult
    Anovulation
    Asian Continental Ancestry Group
    Cardiovascular Diseases
    China
    Female
    Glucose
    Hirsutism
    Humans
    Hyperandrogenism
    Lipid Metabolism
    Metabolic Syndrome
    Phenotype
    Polycystic Ovary Syndrome

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20800551

    Citation

    Guo, M, et al. "Cardiovascular and Metabolic Characteristics of Infertile Chinese Women With PCOS Diagnosed According to the Rotterdam Consensus Criteria." Reproductive Biomedicine Online, vol. 21, no. 4, 2010, pp. 572-80.
    Guo M, Chen ZJ, Macklon NS, et al. Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria. Reprod Biomed Online. 2010;21(4):572-80.
    Guo, M., Chen, Z. J., Macklon, N. S., Shi, Y. H., Westerveld, H. E., Eijkemans, M. J., ... Goverde, A. J. (2010). Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria. Reproductive Biomedicine Online, 21(4), pp. 572-80. doi:10.1016/j.rbmo.2010.04.032.
    Guo M, et al. Cardiovascular and Metabolic Characteristics of Infertile Chinese Women With PCOS Diagnosed According to the Rotterdam Consensus Criteria. Reprod Biomed Online. 2010;21(4):572-80. PubMed PMID: 20800551.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria. AU - Guo,M, AU - Chen,Z J, AU - Macklon,N S, AU - Shi,Y H, AU - Westerveld,H E, AU - Eijkemans,M J, AU - Fauser,B C J M, AU - Goverde,A J, Y1 - 2010/05/06/ PY - 2009/12/22/received PY - 2010/04/26/revised PY - 2010/04/27/accepted PY - 2010/8/31/entrez PY - 2010/8/31/pubmed PY - 2011/1/14/medline SP - 572 EP - 80 JF - Reproductive biomedicine online JO - Reprod. Biomed. Online VL - 21 IS - 4 N2 - Polycystic ovary syndrome (PCOS) is strongly associated with metabolic abnormalities in Western women. However, data from other populations and geographical regions are scarce. This study evaluated cardiovascular and metabolic risk factors in Chinese infertile women diagnosed with PCOS using the 2003 Rotterdam consensus criteria. A total of 615 women representing the four PCOS phenotypes (oligo- or anovulation (AO)+hyperandrogenism (HA)+polycystic ovaries (PCO), AO+HA, AO+PCO and HA+PCO) underwent standardized metabolic screening including a 75g oral glucose tolerance test. All groups presented with similar reproductive characteristics, with the only difference being a significantly higher Ferriman-Gallwey score for hirsutism (P=0.01) in the subgroup characterized by HA+PCO. Overall, the prevalence of metabolic syndrome was 6.4%, with no difference among the four groups (range of 2.3-12.2%). Metabolic syndrome was associated with body mass index (P<0.001), waist/hip ratio (P=0.002), index of insulin resistance (P=0.005) and fasting insulin (P=0.009) in multivariate analysis. Compared with Caucasians and Chinese women in Westernized societies, mainland Chinese women with PCOS have a low risk of metabolic syndrome and its presence does not vary across the specific PCOS phenotypes. SN - 1472-6491 UR - https://www.unboundmedicine.com/medline/citation/20800551/Cardiovascular_and_metabolic_characteristics_of_infertile_Chinese_women_with_PCOS_diagnosed_according_to_the_Rotterdam_consensus_criteria_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1472-6483(10)00293-2 DB - PRIME DP - Unbound Medicine ER -