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Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria.
Reprod Biomed Online 2010; 21(4):572-80RB

Abstract

Polycystic ovary syndrome (PCOS) is strongly associated with metabolic abnormalities in Western women. However, data from other populations and geographical regions are scarce. This study evaluated cardiovascular and metabolic risk factors in Chinese infertile women diagnosed with PCOS using the 2003 Rotterdam consensus criteria. A total of 615 women representing the four PCOS phenotypes (oligo- or anovulation (AO)+hyperandrogenism (HA)+polycystic ovaries (PCO), AO+HA, AO+PCO and HA+PCO) underwent standardized metabolic screening including a 75g oral glucose tolerance test. All groups presented with similar reproductive characteristics, with the only difference being a significantly higher Ferriman-Gallwey score for hirsutism (P=0.01) in the subgroup characterized by HA+PCO. Overall, the prevalence of metabolic syndrome was 6.4%, with no difference among the four groups (range of 2.3-12.2%). Metabolic syndrome was associated with body mass index (P<0.001), waist/hip ratio (P=0.002), index of insulin resistance (P=0.005) and fasting insulin (P=0.009) in multivariate analysis. Compared with Caucasians and Chinese women in Westernized societies, mainland Chinese women with PCOS have a low risk of metabolic syndrome and its presence does not vary across the specific PCOS phenotypes.

Authors+Show Affiliations

Department of Reproductive Medicine and Gynecology, University Medical Center, Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20800551

Citation

Guo, M, et al. "Cardiovascular and Metabolic Characteristics of Infertile Chinese Women With PCOS Diagnosed According to the Rotterdam Consensus Criteria." Reproductive Biomedicine Online, vol. 21, no. 4, 2010, pp. 572-80.
Guo M, Chen ZJ, Macklon NS, et al. Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria. Reprod Biomed Online. 2010;21(4):572-80.
Guo, M., Chen, Z. J., Macklon, N. S., Shi, Y. H., Westerveld, H. E., Eijkemans, M. J., ... Goverde, A. J. (2010). Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria. Reproductive Biomedicine Online, 21(4), pp. 572-80. doi:10.1016/j.rbmo.2010.04.032.
Guo M, et al. Cardiovascular and Metabolic Characteristics of Infertile Chinese Women With PCOS Diagnosed According to the Rotterdam Consensus Criteria. Reprod Biomed Online. 2010;21(4):572-80. PubMed PMID: 20800551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria. AU - Guo,M, AU - Chen,Z J, AU - Macklon,N S, AU - Shi,Y H, AU - Westerveld,H E, AU - Eijkemans,M J, AU - Fauser,B C J M, AU - Goverde,A J, Y1 - 2010/05/06/ PY - 2009/12/22/received PY - 2010/04/26/revised PY - 2010/04/27/accepted PY - 2010/8/31/entrez PY - 2010/8/31/pubmed PY - 2011/1/14/medline SP - 572 EP - 80 JF - Reproductive biomedicine online JO - Reprod. Biomed. Online VL - 21 IS - 4 N2 - Polycystic ovary syndrome (PCOS) is strongly associated with metabolic abnormalities in Western women. However, data from other populations and geographical regions are scarce. This study evaluated cardiovascular and metabolic risk factors in Chinese infertile women diagnosed with PCOS using the 2003 Rotterdam consensus criteria. A total of 615 women representing the four PCOS phenotypes (oligo- or anovulation (AO)+hyperandrogenism (HA)+polycystic ovaries (PCO), AO+HA, AO+PCO and HA+PCO) underwent standardized metabolic screening including a 75g oral glucose tolerance test. All groups presented with similar reproductive characteristics, with the only difference being a significantly higher Ferriman-Gallwey score for hirsutism (P=0.01) in the subgroup characterized by HA+PCO. Overall, the prevalence of metabolic syndrome was 6.4%, with no difference among the four groups (range of 2.3-12.2%). Metabolic syndrome was associated with body mass index (P<0.001), waist/hip ratio (P=0.002), index of insulin resistance (P=0.005) and fasting insulin (P=0.009) in multivariate analysis. Compared with Caucasians and Chinese women in Westernized societies, mainland Chinese women with PCOS have a low risk of metabolic syndrome and its presence does not vary across the specific PCOS phenotypes. SN - 1472-6491 UR - https://www.unboundmedicine.com/medline/citation/20800551/Cardiovascular_and_metabolic_characteristics_of_infertile_Chinese_women_with_PCOS_diagnosed_according_to_the_Rotterdam_consensus_criteria_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1472-6483(10)00293-2 DB - PRIME DP - Unbound Medicine ER -