Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children.Vaccine. 2010 Oct 18; 28(44):7184-92.V
Abstract
Development of natural antibodies to 3 nontypeable Haemophilus influenzae (NTHi) outer membrane proteins (D, P6 and OMP26) was prospectively studied in 130 children 6-30 months of age during NP colonization and acute otitis media (AOM). IgG antibody to protein D, P6 and OMP26 increased with age (p<0.001). Serum IgG responses to NP colonization were different for the 3 proteins: protein D responses occurred at a later age than P6, and OMP26 responses were minimal. For all 3 proteins serum antibody levels in the convalescent phase of AOM infection were not as high as after NP colonization. Antibodies to protein D and P6 but not OMP26 were bactericidal.
Links
MeSH
Antibodies, BacterialAntibody FormationBacterial Outer Membrane ProteinsBacterial ProteinsCarrier ProteinsChild, PreschoolHaemophilus InfectionsHaemophilus VaccinesHaemophilus influenzaeHumansImmunoglobulin DImmunoglobulin GInfantLipoproteinsMultilocus Sequence TypingNasopharynxOtitis MediaProspective Studies
Pub Type(s)
Journal Article
Research Support, N.I.H., Extramural
Language
eng
PubMed ID
20800701
Citation
Pichichero, Michael E., et al. "Antibody Response to Haemophilus Influenzae Outer Membrane Protein D, P6, and OMP26 After Nasopharyngeal Colonization and Acute Otitis Media in Children." Vaccine, vol. 28, no. 44, 2010, pp. 7184-92.
Pichichero ME, Kaur R, Casey JR, et al. Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children. Vaccine. 2010;28(44):7184-92.
Pichichero, M. E., Kaur, R., Casey, J. R., Sabirov, A., Khan, M. N., & Almudevar, A. (2010). Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children. Vaccine, 28(44), 7184-92. https://doi.org/10.1016/j.vaccine.2010.08.063
Pichichero ME, et al. Antibody Response to Haemophilus Influenzae Outer Membrane Protein D, P6, and OMP26 After Nasopharyngeal Colonization and Acute Otitis Media in Children. Vaccine. 2010 Oct 18;28(44):7184-92. PubMed PMID: 20800701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children.
AU - Pichichero,Michael E,
AU - Kaur,Ravinder,
AU - Casey,Janet R,
AU - Sabirov,Albert,
AU - Khan,M Nadeem,
AU - Almudevar,Anthony,
Y1 - 2010/08/26/
PY - 2010/06/21/received
PY - 2010/08/02/revised
PY - 2010/08/12/accepted
PY - 2010/8/31/entrez
PY - 2010/8/31/pubmed
PY - 2011/1/15/medline
SP - 7184
EP - 92
JF - Vaccine
JO - Vaccine
VL - 28
IS - 44
N2 - Development of natural antibodies to 3 nontypeable Haemophilus influenzae (NTHi) outer membrane proteins (D, P6 and OMP26) was prospectively studied in 130 children 6-30 months of age during NP colonization and acute otitis media (AOM). IgG antibody to protein D, P6 and OMP26 increased with age (p<0.001). Serum IgG responses to NP colonization were different for the 3 proteins: protein D responses occurred at a later age than P6, and OMP26 responses were minimal. For all 3 proteins serum antibody levels in the convalescent phase of AOM infection were not as high as after NP colonization. Antibodies to protein D and P6 but not OMP26 were bactericidal.
SN - 1873-2518
UR - https://www.unboundmedicine.com/medline/citation/20800701/Antibody_response_to_Haemophilus_influenzae_outer_membrane_protein_D_P6_and_OMP26_after_nasopharyngeal_colonization_and_acute_otitis_media_in_children_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(10)01220-X
DB - PRIME
DP - Unbound Medicine
ER -
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