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A HPLC method to evaluate the influence of photostabilizers on cosmetic formulations containing UV-filters and vitamins A and E.
Talanta. 2010 Sep 15; 82(4):1490-4.T

Abstract

This paper reports a simple and reliable HPLC method to evaluate the influence of two currently available photostabilizers on cosmetic formulations containing combined UV-filters and vitamins A and E. Vitamins and UV-filters, widely encountered in products of daily use have to be routinely evaluated since photoinstability can lead to reductions in their efficacy and safety. UV-irradiated formulation samples were submitted to a procedure that included a reliable, precise and specific HPLC method employing a C18 column and detection at 325 and 235 nm. Methanol, isopropanol and water were the mobile phases in gradient elution. The method precision was between 0.28 and 5.07. The photostabilizers studied [diethylhexyl 2,6-naphthalate (DEHN) and benzotriazolyl dodecyl p-cresol (BTDC)], influenced the stability of octyl methoxycinnamate (OMC) associated with vitamins A and E. BTDC was considered the best photostabilizer to vitamins and OMC when the UV-filters were combined with both vitamins A and E.

Authors+Show Affiliations

University of Sao Paulo, Faculty of Pharmaceutical Sciences of Ribeirao Preto, Sao Paulo, Brazil. lorena@fcfrp.usp.brNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20801361

Citation

Gaspar, Lorena Rigo, and Patricia Maria Berardo Gonçalves Maia Campos. "A HPLC Method to Evaluate the Influence of Photostabilizers On Cosmetic Formulations Containing UV-filters and Vitamins a and E." Talanta, vol. 82, no. 4, 2010, pp. 1490-4.
Gaspar LR, Campos PM. A HPLC method to evaluate the influence of photostabilizers on cosmetic formulations containing UV-filters and vitamins A and E. Talanta. 2010;82(4):1490-4.
Gaspar, L. R., & Campos, P. M. (2010). A HPLC method to evaluate the influence of photostabilizers on cosmetic formulations containing UV-filters and vitamins A and E. Talanta, 82(4), 1490-4. https://doi.org/10.1016/j.talanta.2010.07.025
Gaspar LR, Campos PM. A HPLC Method to Evaluate the Influence of Photostabilizers On Cosmetic Formulations Containing UV-filters and Vitamins a and E. Talanta. 2010 Sep 15;82(4):1490-4. PubMed PMID: 20801361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A HPLC method to evaluate the influence of photostabilizers on cosmetic formulations containing UV-filters and vitamins A and E. AU - Gaspar,Lorena Rigo, AU - Campos,Patricia Maria Berardo Gonçalves Maia, Y1 - 2010/07/17/ PY - 2010/03/24/received PY - 2010/07/12/revised PY - 2010/07/12/accepted PY - 2010/8/31/entrez PY - 2010/8/31/pubmed PY - 2010/12/16/medline SP - 1490 EP - 4 JF - Talanta JO - Talanta VL - 82 IS - 4 N2 - This paper reports a simple and reliable HPLC method to evaluate the influence of two currently available photostabilizers on cosmetic formulations containing combined UV-filters and vitamins A and E. Vitamins and UV-filters, widely encountered in products of daily use have to be routinely evaluated since photoinstability can lead to reductions in their efficacy and safety. UV-irradiated formulation samples were submitted to a procedure that included a reliable, precise and specific HPLC method employing a C18 column and detection at 325 and 235 nm. Methanol, isopropanol and water were the mobile phases in gradient elution. The method precision was between 0.28 and 5.07. The photostabilizers studied [diethylhexyl 2,6-naphthalate (DEHN) and benzotriazolyl dodecyl p-cresol (BTDC)], influenced the stability of octyl methoxycinnamate (OMC) associated with vitamins A and E. BTDC was considered the best photostabilizer to vitamins and OMC when the UV-filters were combined with both vitamins A and E. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/20801361/A_HPLC_method_to_evaluate_the_influence_of_photostabilizers_on_cosmetic_formulations_containing_UV_filters_and_vitamins_A_and_E_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(10)00539-4 DB - PRIME DP - Unbound Medicine ER -