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Maternal plasma adipokines and insulin concentrations in relation to fetal biometry in the gestational diabetes.
Neuro Endocrinol Lett 2010; 31(4):568-72NE

Abstract

OBJECTIVE

Maternal insulin sensitivity have strong correlation with fetal growth. The dysregulation of adiponectin and leptin is found in insulin resistance. The aim of this study was to determine whether there is an association between ultrasound fetal biometry and the maternal plasma cytokines and insulin concentrations at the beginning of gestational diabetes treatment.

METHODS

121 women with gestational diabetes diagnosed between 26th and 30th weeks, were included to the study. Plasma levels of adiponectin, leptin, insulin and glucose were quantified with the measurements and percentiles of the biparietal diameter, head circumference and abdominal circumference , estimated fetal weight and the actual birthweight.

RESULTS

Associations between both of the adipokines and fetal biometry measurements were not evident. There were also no differences in their serum concentrations between groups of women with and without accelerated fetal growth . Adiponectin negatively correlated with pre-pregnancy BMI (r=-0.366, p=0.01). Leptin positively correlated with pre - pregnancy BMI (r=0.42, p=0.002), fasting insulin (r=0.51, p=0.0006) and HOMA-IR (r=0.43, p=0.005). No association was found between adiponectin, leptin, fasting insulin, HOMA-IR and neonatal birth weight or birth weight percentile.

CONCLUSION

The results of this study imply that adiponectin, leptin and insulin maternal plasma concentrations in the third trimester do not have influence on fetal growth in gestational diabetes.

Authors+Show Affiliations

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20802449

Citation

Bomba-Opon, Dorota A., et al. "Maternal Plasma Adipokines and Insulin Concentrations in Relation to Fetal Biometry in the Gestational Diabetes." Neuro Endocrinology Letters, vol. 31, no. 4, 2010, pp. 568-72.
Bomba-Opon DA, Horosz E, Szymanska M, et al. Maternal plasma adipokines and insulin concentrations in relation to fetal biometry in the gestational diabetes. Neuro Endocrinol Lett. 2010;31(4):568-72.
Bomba-Opon, D. A., Horosz, E., Szymanska, M., & Wielgos, M. (2010). Maternal plasma adipokines and insulin concentrations in relation to fetal biometry in the gestational diabetes. Neuro Endocrinology Letters, 31(4), pp. 568-72.
Bomba-Opon DA, et al. Maternal Plasma Adipokines and Insulin Concentrations in Relation to Fetal Biometry in the Gestational Diabetes. Neuro Endocrinol Lett. 2010;31(4):568-72. PubMed PMID: 20802449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal plasma adipokines and insulin concentrations in relation to fetal biometry in the gestational diabetes. AU - Bomba-Opon,Dorota A, AU - Horosz,Edyta, AU - Szymanska,Monika, AU - Wielgos,Miroslaw, PY - 2009/10/12/received PY - 2010/01/05/accepted PY - 2010/8/31/entrez PY - 2010/8/31/pubmed PY - 2010/12/14/medline SP - 568 EP - 72 JF - Neuro endocrinology letters JO - Neuro Endocrinol. Lett. VL - 31 IS - 4 N2 - OBJECTIVE: Maternal insulin sensitivity have strong correlation with fetal growth. The dysregulation of adiponectin and leptin is found in insulin resistance. The aim of this study was to determine whether there is an association between ultrasound fetal biometry and the maternal plasma cytokines and insulin concentrations at the beginning of gestational diabetes treatment. METHODS: 121 women with gestational diabetes diagnosed between 26th and 30th weeks, were included to the study. Plasma levels of adiponectin, leptin, insulin and glucose were quantified with the measurements and percentiles of the biparietal diameter, head circumference and abdominal circumference , estimated fetal weight and the actual birthweight. RESULTS: Associations between both of the adipokines and fetal biometry measurements were not evident. There were also no differences in their serum concentrations between groups of women with and without accelerated fetal growth . Adiponectin negatively correlated with pre-pregnancy BMI (r=-0.366, p=0.01). Leptin positively correlated with pre - pregnancy BMI (r=0.42, p=0.002), fasting insulin (r=0.51, p=0.0006) and HOMA-IR (r=0.43, p=0.005). No association was found between adiponectin, leptin, fasting insulin, HOMA-IR and neonatal birth weight or birth weight percentile. CONCLUSION: The results of this study imply that adiponectin, leptin and insulin maternal plasma concentrations in the third trimester do not have influence on fetal growth in gestational diabetes. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/20802449/Maternal_plasma_adipokines_and_insulin_concentrations_in_relation_to_fetal_biometry_in_the_gestational_diabetes_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -