Abstract
OBJECTIVE
• To measure urinary nerve growth factor (NGF) in women with overactive bladder (OAB)-dry and OAB-wet and investigate the association of urinary NGF expression with these factors.
PATIENTS AND METHODS
• Differentiation between OAB-wet and OAB-dry was based on symptoms and a 3-day voiding diary. • Urinary NGF levels were measured by enzyme-linked immunosorbent assay (ELISA). • The urinary NGF levels were compared among controls, OAB-dry and OAB-wet subgroups, and also between OAB patients ≥ 55 years and < 55 years, as well as between patients with a body mass index (BMI, kg/m²) < 20, 20-30 and > 30.
RESULTS
• A total of 113 women with OAB-dry, 106 with OAB-wet and 84 controls were enrolled. The urinary NGF/creatinine (Cr) levels were significantly highest in OAB-wet (2.13 ± 3.87) and second highest in OAB-dry (0.265 ± 0.59) compared to controls (0.07 ± 0.21). • Analysis of urinary NGF or NGF/Cr levels among controls, OAB-dry and OAB-wet groups by age and BMI showed no significant differences, except for the OAB-dry group. • Urinary NGF/Cr was not significantly correlated with age (P = 0.088) or BMI (P = 0.886) in women with OAB-dry and OAB-wet.
CONCLUSIONS
• Urinary NGF levels were significantly higher in women with OAB-dry and even higher in women with OAB-wet. • The urinary NGF level was not associated with ageing, menopause or higher BMI either in controls or OAB patients.
TY - JOUR
T1 - Urinary nerve growth factor in women with overactive bladder syndrome.
AU - Liu,Hsin-Tzu,
AU - Chen,Chia-Yen,
AU - Kuo,Hann-Chorng,
Y1 - 2010/08/26/
PY - 2010/9/1/entrez
PY - 2010/9/2/pubmed
PY - 2011/4/26/medline
SP - 799
EP - 803
JF - BJU international
JO - BJU Int
VL - 107
IS - 5
N2 - OBJECTIVE: • To measure urinary nerve growth factor (NGF) in women with overactive bladder (OAB)-dry and OAB-wet and investigate the association of urinary NGF expression with these factors. PATIENTS AND METHODS: • Differentiation between OAB-wet and OAB-dry was based on symptoms and a 3-day voiding diary. • Urinary NGF levels were measured by enzyme-linked immunosorbent assay (ELISA). • The urinary NGF levels were compared among controls, OAB-dry and OAB-wet subgroups, and also between OAB patients ≥ 55 years and < 55 years, as well as between patients with a body mass index (BMI, kg/m²) < 20, 20-30 and > 30. RESULTS: • A total of 113 women with OAB-dry, 106 with OAB-wet and 84 controls were enrolled. The urinary NGF/creatinine (Cr) levels were significantly highest in OAB-wet (2.13 ± 3.87) and second highest in OAB-dry (0.265 ± 0.59) compared to controls (0.07 ± 0.21). • Analysis of urinary NGF or NGF/Cr levels among controls, OAB-dry and OAB-wet groups by age and BMI showed no significant differences, except for the OAB-dry group. • Urinary NGF/Cr was not significantly correlated with age (P = 0.088) or BMI (P = 0.886) in women with OAB-dry and OAB-wet. CONCLUSIONS: • Urinary NGF levels were significantly higher in women with OAB-dry and even higher in women with OAB-wet. • The urinary NGF level was not associated with ageing, menopause or higher BMI either in controls or OAB patients.
SN - 1464-410X
UR - https://www.unboundmedicine.com/medline/citation/20804479/Urinary_nerve_growth_factor_in_women_with_overactive_bladder_syndrome_
L2 - https://doi.org/10.1111/j.1464-410X.2010.09585.x
DB - PRIME
DP - Unbound Medicine
ER -
