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Urinary nerve growth factor in women with overactive bladder syndrome.
BJU Int. 2011 Mar; 107(5):799-803.BI

Abstract

OBJECTIVE

• To measure urinary nerve growth factor (NGF) in women with overactive bladder (OAB)-dry and OAB-wet and investigate the association of urinary NGF expression with these factors.

PATIENTS AND METHODS

• Differentiation between OAB-wet and OAB-dry was based on symptoms and a 3-day voiding diary. • Urinary NGF levels were measured by enzyme-linked immunosorbent assay (ELISA). • The urinary NGF levels were compared among controls, OAB-dry and OAB-wet subgroups, and also between OAB patients ≥ 55 years and < 55 years, as well as between patients with a body mass index (BMI, kg/m²) < 20, 20-30 and > 30.

RESULTS

• A total of 113 women with OAB-dry, 106 with OAB-wet and 84 controls were enrolled. The urinary NGF/creatinine (Cr) levels were significantly highest in OAB-wet (2.13 ± 3.87) and second highest in OAB-dry (0.265 ± 0.59) compared to controls (0.07 ± 0.21). • Analysis of urinary NGF or NGF/Cr levels among controls, OAB-dry and OAB-wet groups by age and BMI showed no significant differences, except for the OAB-dry group. • Urinary NGF/Cr was not significantly correlated with age (P = 0.088) or BMI (P = 0.886) in women with OAB-dry and OAB-wet.

CONCLUSIONS

• Urinary NGF levels were significantly higher in women with OAB-dry and even higher in women with OAB-wet. • The urinary NGF level was not associated with ageing, menopause or higher BMI either in controls or OAB patients.

Authors+Show Affiliations

Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20804479

Citation

Liu, Hsin-Tzu, et al. "Urinary Nerve Growth Factor in Women With Overactive Bladder Syndrome." BJU International, vol. 107, no. 5, 2011, pp. 799-803.
Liu HT, Chen CY, Kuo HC. Urinary nerve growth factor in women with overactive bladder syndrome. BJU Int. 2011;107(5):799-803.
Liu, H. T., Chen, C. Y., & Kuo, H. C. (2011). Urinary nerve growth factor in women with overactive bladder syndrome. BJU International, 107(5), 799-803. https://doi.org/10.1111/j.1464-410X.2010.09585.x
Liu HT, Chen CY, Kuo HC. Urinary Nerve Growth Factor in Women With Overactive Bladder Syndrome. BJU Int. 2011;107(5):799-803. PubMed PMID: 20804479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary nerve growth factor in women with overactive bladder syndrome. AU - Liu,Hsin-Tzu, AU - Chen,Chia-Yen, AU - Kuo,Hann-Chorng, Y1 - 2010/08/26/ PY - 2010/9/1/entrez PY - 2010/9/2/pubmed PY - 2011/4/26/medline SP - 799 EP - 803 JF - BJU international JO - BJU Int VL - 107 IS - 5 N2 - OBJECTIVE: • To measure urinary nerve growth factor (NGF) in women with overactive bladder (OAB)-dry and OAB-wet and investigate the association of urinary NGF expression with these factors. PATIENTS AND METHODS: • Differentiation between OAB-wet and OAB-dry was based on symptoms and a 3-day voiding diary. • Urinary NGF levels were measured by enzyme-linked immunosorbent assay (ELISA). • The urinary NGF levels were compared among controls, OAB-dry and OAB-wet subgroups, and also between OAB patients ≥ 55 years and < 55 years, as well as between patients with a body mass index (BMI, kg/m²) < 20, 20-30 and > 30. RESULTS: • A total of 113 women with OAB-dry, 106 with OAB-wet and 84 controls were enrolled. The urinary NGF/creatinine (Cr) levels were significantly highest in OAB-wet (2.13 ± 3.87) and second highest in OAB-dry (0.265 ± 0.59) compared to controls (0.07 ± 0.21). • Analysis of urinary NGF or NGF/Cr levels among controls, OAB-dry and OAB-wet groups by age and BMI showed no significant differences, except for the OAB-dry group. • Urinary NGF/Cr was not significantly correlated with age (P = 0.088) or BMI (P = 0.886) in women with OAB-dry and OAB-wet. CONCLUSIONS: • Urinary NGF levels were significantly higher in women with OAB-dry and even higher in women with OAB-wet. • The urinary NGF level was not associated with ageing, menopause or higher BMI either in controls or OAB patients. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/20804479/Urinary_nerve_growth_factor_in_women_with_overactive_bladder_syndrome_ L2 - https://doi.org/10.1111/j.1464-410X.2010.09585.x DB - PRIME DP - Unbound Medicine ER -