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Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet.
J Biomed Sci 2010; 17 Suppl 1:S39JB

Abstract

BACKGROUND

Nelumbo nucifera, known as sacred lotus, is a well-known medicinal plant and this lotus root is commonly used as food compared to different parts of this plant. This study was conducted to investigate the antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in high fat diet-induced obese rats.

METHODS

Thirty-two male Sprague-Dawley rats (4-week-old) were randomly divided into four groups (n=8) for 6 weeks (normal diet, N group; high fat diet, HF group; high fat diet + lotus root hot water extract, HFR group; high fat diet + lotus root hot water extract + taurine, HFRT group). Lotus root hot water extract was orally administrated (400 mg/kg/day) to HFR and HFRT groups and the same amount of distilled water was orally administered to N and HF groups. Taurine was supplemented by dissolving in feed water (3% w/v).

RESULTS

The activities of glutamate oxaloacetate transaminase and glutamate pyruvate transaminase in serum were lower in HFR and HFRT groups compared to HF group. Thiobarbituric acid reactive substance contents in all groups fed a high fat diet were higher compared to N group. The activities of hepatic antioxidant enzymes were higher in HFR and HFRT groups compared to HF group.

CONCLUSIONS

These results suggest that lotus root hot water extract with taurine supplementation shows antioxidant and hepatic protective effects in high fat diet-induced obese rats.

Authors+Show Affiliations

Department of Food and Nutrition, Inha University, Incheon, Korea. sderic@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20804615

Citation

Du, Huan, et al. "Antioxidant and Hepatic Protective Effects of Lotus Root Hot Water Extract With Taurine Supplementation in Rats Fed a High Fat Diet." Journal of Biomedical Science, vol. 17 Suppl 1, 2010, pp. S39.
Du H, Zhao X, You JS, et al. Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet. J Biomed Sci. 2010;17 Suppl 1:S39.
Du, H., Zhao, X., You, J. S., Park, J. Y., Kim, S. H., & Chang, K. J. (2010). Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet. Journal of Biomedical Science, 17 Suppl 1, pp. S39. doi:10.1186/1423-0127-17-S1-S39.
Du H, et al. Antioxidant and Hepatic Protective Effects of Lotus Root Hot Water Extract With Taurine Supplementation in Rats Fed a High Fat Diet. J Biomed Sci. 2010 Aug 24;17 Suppl 1:S39. PubMed PMID: 20804615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet. AU - Du,Huan, AU - Zhao,Xu, AU - You,Jeong-Soon, AU - Park,Ji-Yeon, AU - Kim,Sung-Hoon, AU - Chang,Kyung-Ja, Y1 - 2010/08/24/ PY - 2010/9/1/entrez PY - 2010/9/11/pubmed PY - 2011/2/2/medline SP - S39 EP - S39 JF - Journal of biomedical science JO - J. Biomed. Sci. VL - 17 Suppl 1 N2 - BACKGROUND: Nelumbo nucifera, known as sacred lotus, is a well-known medicinal plant and this lotus root is commonly used as food compared to different parts of this plant. This study was conducted to investigate the antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in high fat diet-induced obese rats. METHODS: Thirty-two male Sprague-Dawley rats (4-week-old) were randomly divided into four groups (n=8) for 6 weeks (normal diet, N group; high fat diet, HF group; high fat diet + lotus root hot water extract, HFR group; high fat diet + lotus root hot water extract + taurine, HFRT group). Lotus root hot water extract was orally administrated (400 mg/kg/day) to HFR and HFRT groups and the same amount of distilled water was orally administered to N and HF groups. Taurine was supplemented by dissolving in feed water (3% w/v). RESULTS: The activities of glutamate oxaloacetate transaminase and glutamate pyruvate transaminase in serum were lower in HFR and HFRT groups compared to HF group. Thiobarbituric acid reactive substance contents in all groups fed a high fat diet were higher compared to N group. The activities of hepatic antioxidant enzymes were higher in HFR and HFRT groups compared to HF group. CONCLUSIONS: These results suggest that lotus root hot water extract with taurine supplementation shows antioxidant and hepatic protective effects in high fat diet-induced obese rats. SN - 1423-0127 UR - https://www.unboundmedicine.com/medline/citation/20804615/Antioxidant_and_hepatic_protective_effects_of_lotus_root_hot_water_extract_with_taurine_supplementation_in_rats_fed_a_high_fat_diet_ L2 - https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-17-S1-S39 DB - PRIME DP - Unbound Medicine ER -