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Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet.
J Biomed Sci 2010; 17 Suppl 1:S42JB

Abstract

BACKGROUND

Lotus (Nelumbo nucifera) leaf has been used to treat obesity. The purpose of this study was to investigate the antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in high fat diet-induced obese rats.

METHODS

Four week-old male Sprague-Dawley rats were randomly divided into four groups with 8 rats in each group for a period of 6 weeks (normal diet, N group; high fat diet, HF group; high fat diet + lotus leaf hot water extract, HFL group; high fat diet + lotus leaf hot water extract + taurine, HFLT group). Lotus leaf hot water extract was orally administrated to HFL and HFLT groups and the same amount of distilled water was orally administered (400 mg/kg/day) to N and HF groups. Taurine was supplemented by dissolving in feed water (3% w/v).

RESULTS

The body weight gain and relative weights of epididymal and retroperitoneal adipose tissues were significantly lower in N, HFL and HFLT groups compared to HF group. HFL and HFLT groups showed lower concentrations of total cholesterol, triglyceride and low density lipoprotein cholesterol in serum. HFLT group showed higher the ratio of high density lipoprotein cholesterol/total cholesterol compared to HFL group. HFLT group showed better blood lipid profiles compared to HFL group.

CONCLUSIONS

Lotus leaf hot water extract with taurine supplementation showed antiobesity and hypolipidemic effects in high fat diet-induced obese rats, which was more effective than lotus leaf hot water extract alone.

Authors+Show Affiliations

Department of Food and Nutrition, Inha University, Incheon, Korea. sderic@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20804619

Citation

Du, Huan, et al. "Antiobesity and Hypolipidemic Effects of Lotus Leaf Hot Water Extract With Taurine Supplementation in Rats Fed a High Fat Diet." Journal of Biomedical Science, vol. 17 Suppl 1, 2010, pp. S42.
Du H, You JS, Zhao X, et al. Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet. J Biomed Sci. 2010;17 Suppl 1:S42.
Du, H., You, J. S., Zhao, X., Park, J. Y., Kim, S. H., & Chang, K. J. (2010). Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet. Journal of Biomedical Science, 17 Suppl 1, pp. S42. doi:10.1186/1423-0127-17-S1-S42.
Du H, et al. Antiobesity and Hypolipidemic Effects of Lotus Leaf Hot Water Extract With Taurine Supplementation in Rats Fed a High Fat Diet. J Biomed Sci. 2010 Aug 24;17 Suppl 1:S42. PubMed PMID: 20804619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet. AU - Du,Huan, AU - You,Jeong-Soon, AU - Zhao,Xu, AU - Park,Ji-Yeon, AU - Kim,Sung-Hoon, AU - Chang,Kyung-Ja, Y1 - 2010/08/24/ PY - 2010/9/1/entrez PY - 2010/9/11/pubmed PY - 2011/2/2/medline SP - S42 EP - S42 JF - Journal of biomedical science JO - J. Biomed. Sci. VL - 17 Suppl 1 N2 - BACKGROUND: Lotus (Nelumbo nucifera) leaf has been used to treat obesity. The purpose of this study was to investigate the antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in high fat diet-induced obese rats. METHODS: Four week-old male Sprague-Dawley rats were randomly divided into four groups with 8 rats in each group for a period of 6 weeks (normal diet, N group; high fat diet, HF group; high fat diet + lotus leaf hot water extract, HFL group; high fat diet + lotus leaf hot water extract + taurine, HFLT group). Lotus leaf hot water extract was orally administrated to HFL and HFLT groups and the same amount of distilled water was orally administered (400 mg/kg/day) to N and HF groups. Taurine was supplemented by dissolving in feed water (3% w/v). RESULTS: The body weight gain and relative weights of epididymal and retroperitoneal adipose tissues were significantly lower in N, HFL and HFLT groups compared to HF group. HFL and HFLT groups showed lower concentrations of total cholesterol, triglyceride and low density lipoprotein cholesterol in serum. HFLT group showed higher the ratio of high density lipoprotein cholesterol/total cholesterol compared to HFL group. HFLT group showed better blood lipid profiles compared to HFL group. CONCLUSIONS: Lotus leaf hot water extract with taurine supplementation showed antiobesity and hypolipidemic effects in high fat diet-induced obese rats, which was more effective than lotus leaf hot water extract alone. SN - 1423-0127 UR - https://www.unboundmedicine.com/medline/citation/20804619/Antiobesity_and_hypolipidemic_effects_of_lotus_leaf_hot_water_extract_with_taurine_supplementation_in_rats_fed_a_high_fat_diet_ L2 - https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-17-S1-S42 DB - PRIME DP - Unbound Medicine ER -