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Exploring newer cardioprotective strategies: ω-3 fatty acids in perspective.
Thromb Haemost 2010; 104(4):664-80TH

Abstract

In the 1980s, observational retrospective studies showed an inverse relation between coronary heart disease (CHD) and consumption of fish containing fatty acids that belong to the omega (ω)-3 family. Large case-control studies and prospective intervention trials consistently showed that ω-3 fatty acids supplementation lowers fatal myocardial infarction (MI) and sudden cardiac death. By analysing the strengths of the results of individual studies and how the meta-analyses agree with them, putting together relevant backgrounds, and identifying open questions, the following findings/directions emerge. (i) Dietary and non-dietary intake of ω-3 fatty acids reduces overall mortality, mortality due to MI, and sudden death in patients with CHD; (ii) Fish oil consumption directly or indirectly affects cardiac electrophysiology. Fish oil reduces heart rate, a major risk factor for sudden death; (iii) Among patients with implantable cardioverter defibrillators, ω-3 fatty acids do not reduce the risk of ventricular tachycardia/ventricular fibrillation and may actually be pro-arrhythmic; (iv) The consumption of ω-3 fatty acids leads to a 10-33% net decrease of triglyceride levels. The effect is dose-dependent, larger in studies with higher mean baseline triglyceride levels, and consistent in different populations (healthy people, people with dyslipidaemia, diabetes, or known cardiovascular risk factors); (v) Outcomes for which a small beneficial effect ω-3 fatty acids is found include blood pressure (about 2 mmHg reduction), re-stenosis rates after coronary angioplasty (14% reduction), and exercise tolerance testing. Major experimental data provide strength (biological plausibility) for these findings, and define directions for newer clinical trials with ω-3 fatty acids.

Authors+Show Affiliations

Department of Experimental and Clinical Medicine, Federico II University, Naples, Italy. dario.diminno@hotmail.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20806105

Citation

Di Minno, Matteo Nicola Dario, et al. "Exploring Newer Cardioprotective Strategies: Ω-3 Fatty Acids in Perspective." Thrombosis and Haemostasis, vol. 104, no. 4, 2010, pp. 664-80.
Di Minno MN, Tremoli E, Tufano A, et al. Exploring newer cardioprotective strategies: ω-3 fatty acids in perspective. Thromb Haemost. 2010;104(4):664-80.
Di Minno, M. N., Tremoli, E., Tufano, A., Russolillo, A., Lupoli, R., & Di Minno, G. (2010). Exploring newer cardioprotective strategies: ω-3 fatty acids in perspective. Thrombosis and Haemostasis, 104(4), pp. 664-80. doi:10.1160/TH10-01-0008.
Di Minno MN, et al. Exploring Newer Cardioprotective Strategies: Ω-3 Fatty Acids in Perspective. Thromb Haemost. 2010;104(4):664-80. PubMed PMID: 20806105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exploring newer cardioprotective strategies: ω-3 fatty acids in perspective. AU - Di Minno,Matteo Nicola Dario, AU - Tremoli,Elena, AU - Tufano,Antonella, AU - Russolillo,Anna, AU - Lupoli,Roberta, AU - Di Minno,Giovanni, Y1 - 2010/08/30/ PY - 2010/01/04/received PY - 2010/05/29/accepted PY - 2010/9/1/entrez PY - 2010/9/2/pubmed PY - 2011/5/12/medline SP - 664 EP - 80 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 104 IS - 4 N2 - In the 1980s, observational retrospective studies showed an inverse relation between coronary heart disease (CHD) and consumption of fish containing fatty acids that belong to the omega (ω)-3 family. Large case-control studies and prospective intervention trials consistently showed that ω-3 fatty acids supplementation lowers fatal myocardial infarction (MI) and sudden cardiac death. By analysing the strengths of the results of individual studies and how the meta-analyses agree with them, putting together relevant backgrounds, and identifying open questions, the following findings/directions emerge. (i) Dietary and non-dietary intake of ω-3 fatty acids reduces overall mortality, mortality due to MI, and sudden death in patients with CHD; (ii) Fish oil consumption directly or indirectly affects cardiac electrophysiology. Fish oil reduces heart rate, a major risk factor for sudden death; (iii) Among patients with implantable cardioverter defibrillators, ω-3 fatty acids do not reduce the risk of ventricular tachycardia/ventricular fibrillation and may actually be pro-arrhythmic; (iv) The consumption of ω-3 fatty acids leads to a 10-33% net decrease of triglyceride levels. The effect is dose-dependent, larger in studies with higher mean baseline triglyceride levels, and consistent in different populations (healthy people, people with dyslipidaemia, diabetes, or known cardiovascular risk factors); (v) Outcomes for which a small beneficial effect ω-3 fatty acids is found include blood pressure (about 2 mmHg reduction), re-stenosis rates after coronary angioplasty (14% reduction), and exercise tolerance testing. Major experimental data provide strength (biological plausibility) for these findings, and define directions for newer clinical trials with ω-3 fatty acids. SN - 2567-689X UR - https://www.unboundmedicine.com/medline/citation/20806105/Exploring_newer_cardioprotective_strategies:_ω_3_fatty_acids_in_perspective_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1160/TH10-01-0008 DB - PRIME DP - Unbound Medicine ER -