Tags

Type your tag names separated by a space and hit enter

Synthesis and in vitro antimicrobial activity of novel N-(6-chlorobenzo[d]thiazol-2-yl) hydrazine carboxamide derivatives of benzothiazole class.
J Enzyme Inhib Med Chem. 2011 Jun; 26(3):332-40.JE

Abstract

In this study, a series of novel 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole (6a-g) and 1,3,4-oxadiazole (7a-g, 8) were synthesized from N-(6-chlorobenzo[d]thiazol-2-yl) hydrazine carboxamide derivatives of benzothiazole class. Antimicrobial properties of the title compound derivatives were investigated against one Gram (+) bacteria (Staphylococcus aureus), three Gram (-) bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and five fungi (Candida albicans, Aspergillus niger, Aspergillus flavus, Monascus purpureus and Penicillium citrinum) using serial plate dilution method. The investigation of antibacterial and antifungal screening data revealed that all the tested compounds showed moderate to good inhibition at 12.5-100 µg/mL in DMSO. It has been observed that triazolo-thiadiazole derivatives are found to be more active than 1,3,4-oxadiazole derivatives against all pathogenic bacterial and fungal strains.

Authors+Show Affiliations

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, India. gilanisadaf@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20807086

Citation

Gilani, Sadaf J., et al. "Synthesis and in Vitro Antimicrobial Activity of Novel N-(6-chlorobenzo[d]thiazol-2-yl) Hydrazine Carboxamide Derivatives of Benzothiazole Class." Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 26, no. 3, 2011, pp. 332-40.
Gilani SJ, Khan SA, Siddiqui N, et al. Synthesis and in vitro antimicrobial activity of novel N-(6-chlorobenzo[d]thiazol-2-yl) hydrazine carboxamide derivatives of benzothiazole class. J Enzyme Inhib Med Chem. 2011;26(3):332-40.
Gilani, S. J., Khan, S. A., Siddiqui, N., Verma, S. P., Mullick, P., & Alam, O. (2011). Synthesis and in vitro antimicrobial activity of novel N-(6-chlorobenzo[d]thiazol-2-yl) hydrazine carboxamide derivatives of benzothiazole class. Journal of Enzyme Inhibition and Medicinal Chemistry, 26(3), 332-40. https://doi.org/10.3109/14756366.2010.508441
Gilani SJ, et al. Synthesis and in Vitro Antimicrobial Activity of Novel N-(6-chlorobenzo[d]thiazol-2-yl) Hydrazine Carboxamide Derivatives of Benzothiazole Class. J Enzyme Inhib Med Chem. 2011;26(3):332-40. PubMed PMID: 20807086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and in vitro antimicrobial activity of novel N-(6-chlorobenzo[d]thiazol-2-yl) hydrazine carboxamide derivatives of benzothiazole class. AU - Gilani,Sadaf J, AU - Khan,Suroor A, AU - Siddiqui,Nadeem, AU - Verma,Suraj P, AU - Mullick,Pooja, AU - Alam,Ozair, Y1 - 2010/08/31/ PY - 2010/9/3/entrez PY - 2010/9/3/pubmed PY - 2011/10/15/medline SP - 332 EP - 40 JF - Journal of enzyme inhibition and medicinal chemistry JO - J Enzyme Inhib Med Chem VL - 26 IS - 3 N2 - In this study, a series of novel 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole (6a-g) and 1,3,4-oxadiazole (7a-g, 8) were synthesized from N-(6-chlorobenzo[d]thiazol-2-yl) hydrazine carboxamide derivatives of benzothiazole class. Antimicrobial properties of the title compound derivatives were investigated against one Gram (+) bacteria (Staphylococcus aureus), three Gram (-) bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and five fungi (Candida albicans, Aspergillus niger, Aspergillus flavus, Monascus purpureus and Penicillium citrinum) using serial plate dilution method. The investigation of antibacterial and antifungal screening data revealed that all the tested compounds showed moderate to good inhibition at 12.5-100 µg/mL in DMSO. It has been observed that triazolo-thiadiazole derivatives are found to be more active than 1,3,4-oxadiazole derivatives against all pathogenic bacterial and fungal strains. SN - 1475-6374 UR - https://www.unboundmedicine.com/medline/citation/20807086/Synthesis_and_in_vitro_antimicrobial_activity_of_novel_N__6_chlorobenzo[d]thiazol_2_yl__hydrazine_carboxamide_derivatives_of_benzothiazole_class_ L2 - https://www.tandfonline.com/doi/full/10.3109/14756366.2010.508441 DB - PRIME DP - Unbound Medicine ER -