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Metabolic syndrome in adolescents with polycystic ovary syndrome.
Gynecol Endocrinol. 2011 Oct; 27(10):820-2.GE

Abstract

The aim of the presented study is to evaluate metabolic features in adolescents with polycystic ovary syndrome (PCOS) in comparison with age- and BMI-matched subjects. Forty-three adolescents with PCOS according to ESHRE criteria were prospectively evaluated and compared with 48 control subjects. Blood sampling was done in the early follicular phase of menstrual cycle, between 1st and 5th day, for plasma glucose, total and high-density lipoprotein (HDL)-cholesterol, triglycerides, insulin and C peptide. The diagnosis of metabolic syndrome was done according to IDF adolescent criteria. Adolescents with PCOS have increased low-density lipoprotein (LDL)-cholesterol (p < 0.002), decreased HDL-cholesterol (p <0.0007) and increased C peptide levels (p < 0.02) in comparison with healthy adolescents. Total cholesterol, triglycerides, fasting blood glucose, fasting insulin, HOMA-IR, waist-to-hip ratio, systolic and diastolic blood pressure did not differ between the groups. There was no difference when we compared the prevalence of adolescents with at least one feature of metabolic syndrome between PCOS (17 from 43) and healthy controls (27 from 48). In conclusion, adolescents with PCOS have less favourable blood lipid profiles with higher LDL-cholesterol and lower levels of HDL-cholesterol and are more insulin resistant than their healthy counterparts having higher fasting C peptide levels.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Vrbíková J
Department of Clinical Endocrinology, Institute of Endocrinology, Národní 8, Prague 1, 116 94 Czech Republic. jvrbikova@endo.cz
Zamrazilová H
No affiliation info available
Sedláčková B
No affiliation info available
Šnajderová M
No affiliation info available

MeSH

AdolescentAdultBody Mass IndexC-PeptideCholesterol, HDLCholesterol, LDLCzech RepublicFemaleFollicular PhaseHumansHypercholesterolemiaInsulin ResistanceMetabolic SyndromeObesityPolycystic Ovary SyndromePrevalenceProspective StudiesYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20807165

Citation

Vrbíková, Jana, et al. "Metabolic Syndrome in Adolescents With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 27, no. 10, 2011, pp. 820-2.
Vrbíková J, Zamrazilová H, Sedláčková B, et al. Metabolic syndrome in adolescents with polycystic ovary syndrome. Gynecol Endocrinol. 2011;27(10):820-2.
Vrbíková, J., Zamrazilová, H., Sedláčková, B., & Šnajderová, M. (2011). Metabolic syndrome in adolescents with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 27(10), 820-2. https://doi.org/10.3109/09513590.2010.508851
Vrbíková J, et al. Metabolic Syndrome in Adolescents With Polycystic Ovary Syndrome. Gynecol Endocrinol. 2011;27(10):820-2. PubMed PMID: 20807165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome in adolescents with polycystic ovary syndrome. AU - Vrbíková,Jana, AU - Zamrazilová,Hana, AU - Sedláčková,Barbora, AU - Šnajderová,Marta, Y1 - 2010/09/01/ PY - 2010/9/3/entrez PY - 2010/9/3/pubmed PY - 2012/3/1/medline SP - 820 EP - 2 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 27 IS - 10 N2 - The aim of the presented study is to evaluate metabolic features in adolescents with polycystic ovary syndrome (PCOS) in comparison with age- and BMI-matched subjects. Forty-three adolescents with PCOS according to ESHRE criteria were prospectively evaluated and compared with 48 control subjects. Blood sampling was done in the early follicular phase of menstrual cycle, between 1st and 5th day, for plasma glucose, total and high-density lipoprotein (HDL)-cholesterol, triglycerides, insulin and C peptide. The diagnosis of metabolic syndrome was done according to IDF adolescent criteria. Adolescents with PCOS have increased low-density lipoprotein (LDL)-cholesterol (p < 0.002), decreased HDL-cholesterol (p <0.0007) and increased C peptide levels (p < 0.02) in comparison with healthy adolescents. Total cholesterol, triglycerides, fasting blood glucose, fasting insulin, HOMA-IR, waist-to-hip ratio, systolic and diastolic blood pressure did not differ between the groups. There was no difference when we compared the prevalence of adolescents with at least one feature of metabolic syndrome between PCOS (17 from 43) and healthy controls (27 from 48). In conclusion, adolescents with PCOS have less favourable blood lipid profiles with higher LDL-cholesterol and lower levels of HDL-cholesterol and are more insulin resistant than their healthy counterparts having higher fasting C peptide levels. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/20807165/Metabolic_syndrome_in_adolescents_with_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -