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On the effects of a plant extract of Orthosiphon stamineus on sebum-related skin imperfections.
Int J Cosmet Sci 2011; 33(1):44-52IJ

Abstract

Overproduction of sebum is very common and results in an undesirable oily, shiny complexion with enlarged pores. Sebum secretion is basically under the control of 5-α reductase, and more particularly under that of type 1 isozyme. But it is also highly sensitive to environmental factors such as temperature, humidity and food. Moreover, in Asia, the edicts of a flawless facial skin turn oily skin into a major concern for Asian women. We identified Orthosiphon stamineus leaf extract as an interesting ingredient for reducing the oily appearance of skin thanks to its ability to reduce 5-α reductase type 1 expression in normal human epidermal keratinocytes in vitro. This was confirmed ex vivo, where Orthosiphon stamineus leaf extract was shown to reduce 5-α reductase activity as well as the production of squalene, one of the main components of sebum that was used as a tracer of sebum. To evaluate the efficacy of Orthosiphon stamineus leaf extract at reducing sebum-related skin imperfections in vivo, we performed two different clinical studies, one in France on a panel of Caucasian volunteers and the other one in Thailand on a panel of Asian volunteers. Using instrumental techniques as well as clinical evaluation and self-evaluation, we could highlight that an O/W cosmetic formula containing 2% of Orthosiphon stamineus leaf extract could visibly reduce the oily appearance of skin as well as the size of pores, thus leading to a significant improvement of complexion evenness and radiance. Overall, the results obtained were better than those observed with the same formula containing 1% of zinc gluconate, an ingredient frequently used in oily skin care products.

Authors+Show Affiliations

BASF Beauty Care Solutions France SAS, 32 rue Saint-Jean-de-Dieu, Lyon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20807263

Citation

Vogelgesang, B, et al. "On the Effects of a Plant Extract of Orthosiphon Stamineus On Sebum-related Skin Imperfections." International Journal of Cosmetic Science, vol. 33, no. 1, 2011, pp. 44-52.
Vogelgesang B, Abdul-Malak N, Reymermier C, et al. On the effects of a plant extract of Orthosiphon stamineus on sebum-related skin imperfections. Int J Cosmet Sci. 2011;33(1):44-52.
Vogelgesang, B., Abdul-Malak, N., Reymermier, C., Altobelli, C., & Saget, J. (2011). On the effects of a plant extract of Orthosiphon stamineus on sebum-related skin imperfections. International Journal of Cosmetic Science, 33(1), pp. 44-52. doi:10.1111/j.1468-2494.2010.00581.x.
Vogelgesang B, et al. On the Effects of a Plant Extract of Orthosiphon Stamineus On Sebum-related Skin Imperfections. Int J Cosmet Sci. 2011;33(1):44-52. PubMed PMID: 20807263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On the effects of a plant extract of Orthosiphon stamineus on sebum-related skin imperfections. AU - Vogelgesang,B, AU - Abdul-Malak,N, AU - Reymermier,C, AU - Altobelli,C, AU - Saget,J, Y1 - 2010/08/30/ PY - 2010/9/3/entrez PY - 2010/9/3/pubmed PY - 2011/5/3/medline SP - 44 EP - 52 JF - International journal of cosmetic science JO - Int J Cosmet Sci VL - 33 IS - 1 N2 - Overproduction of sebum is very common and results in an undesirable oily, shiny complexion with enlarged pores. Sebum secretion is basically under the control of 5-α reductase, and more particularly under that of type 1 isozyme. But it is also highly sensitive to environmental factors such as temperature, humidity and food. Moreover, in Asia, the edicts of a flawless facial skin turn oily skin into a major concern for Asian women. We identified Orthosiphon stamineus leaf extract as an interesting ingredient for reducing the oily appearance of skin thanks to its ability to reduce 5-α reductase type 1 expression in normal human epidermal keratinocytes in vitro. This was confirmed ex vivo, where Orthosiphon stamineus leaf extract was shown to reduce 5-α reductase activity as well as the production of squalene, one of the main components of sebum that was used as a tracer of sebum. To evaluate the efficacy of Orthosiphon stamineus leaf extract at reducing sebum-related skin imperfections in vivo, we performed two different clinical studies, one in France on a panel of Caucasian volunteers and the other one in Thailand on a panel of Asian volunteers. Using instrumental techniques as well as clinical evaluation and self-evaluation, we could highlight that an O/W cosmetic formula containing 2% of Orthosiphon stamineus leaf extract could visibly reduce the oily appearance of skin as well as the size of pores, thus leading to a significant improvement of complexion evenness and radiance. Overall, the results obtained were better than those observed with the same formula containing 1% of zinc gluconate, an ingredient frequently used in oily skin care products. SN - 1468-2494 UR - https://www.unboundmedicine.com/medline/citation/20807263/On_the_effects_of_a_plant_extract_of_Orthosiphon_stamineus_on_sebum_related_skin_imperfections_ L2 - https://doi.org/10.1111/j.1468-2494.2010.00581.x DB - PRIME DP - Unbound Medicine ER -