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Lymphocytic adenohypophysitis and adrenalitis in a dog with adrenal and thyroid atrophy.
Vet Pathol. 2010 Nov; 47(6):1082-5.VP

Abstract

A 4.5-year-old spayed female Great Pyrenees with hypothyroidism and hypoadrenocorticism had a slightly enlarged pituitary gland and bilaterally atrophic adrenal and thyroid glands. Lymphocytic adenohypophysitis and adrenalitis were found in which B lymphocytes and plasma cells dominated the adenohypophysitis but T cells dominated the adrenalitis. The thyroid gland had extensive follicular atrophy and collapse. The combination of primary hypothyroidism and hypoadrenocorticism resembles type II autoimmune polyendocrine syndrome or Schmidt syndrome in humans. Adenohypophysitis is rare in dogs and not reported in polyendocrine disease in animals.

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Authors+Show Affiliations

Adissu HA
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, N1G 2W1, Canada. hadissu@uoguelph.ca
Hamel-Jolette A
No affiliation info available
Foster RA
No affiliation info available

MeSH

Adrenal GlandsAnimalsAtrophyAutoimmune DiseasesDog DiseasesDogsFemaleHypothyroidismLymphocytesPituitary DiseasesPituitary GlandPlasma CellsThyroid Gland

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20807820

Citation

Adissu, H A., et al. "Lymphocytic Adenohypophysitis and Adrenalitis in a Dog With Adrenal and Thyroid Atrophy." Veterinary Pathology, vol. 47, no. 6, 2010, pp. 1082-5.
Adissu HA, Hamel-Jolette A, Foster RA. Lymphocytic adenohypophysitis and adrenalitis in a dog with adrenal and thyroid atrophy. Vet Pathol. 2010;47(6):1082-5.
Adissu, H. A., Hamel-Jolette, A., & Foster, R. A. (2010). Lymphocytic adenohypophysitis and adrenalitis in a dog with adrenal and thyroid atrophy. Veterinary Pathology, 47(6), 1082-5. https://doi.org/10.1177/0300985810382520
Adissu HA, Hamel-Jolette A, Foster RA. Lymphocytic Adenohypophysitis and Adrenalitis in a Dog With Adrenal and Thyroid Atrophy. Vet Pathol. 2010;47(6):1082-5. PubMed PMID: 20807820.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lymphocytic adenohypophysitis and adrenalitis in a dog with adrenal and thyroid atrophy. AU - Adissu,H A, AU - Hamel-Jolette,A, AU - Foster,R A, Y1 - 2010/08/31/ PY - 2010/9/3/entrez PY - 2010/9/3/pubmed PY - 2011/3/12/medline SP - 1082 EP - 5 JF - Veterinary pathology JO - Vet Pathol VL - 47 IS - 6 N2 - A 4.5-year-old spayed female Great Pyrenees with hypothyroidism and hypoadrenocorticism had a slightly enlarged pituitary gland and bilaterally atrophic adrenal and thyroid glands. Lymphocytic adenohypophysitis and adrenalitis were found in which B lymphocytes and plasma cells dominated the adenohypophysitis but T cells dominated the adrenalitis. The thyroid gland had extensive follicular atrophy and collapse. The combination of primary hypothyroidism and hypoadrenocorticism resembles type II autoimmune polyendocrine syndrome or Schmidt syndrome in humans. Adenohypophysitis is rare in dogs and not reported in polyendocrine disease in animals. SN - 1544-2217 UR - https://www.unboundmedicine.com/medline/citation/20807820/Lymphocytic_adenohypophysitis_and_adrenalitis_in_a_dog_with_adrenal_and_thyroid_atrophy_ L2 - https://journals.sagepub.com/doi/10.1177/0300985810382520?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -