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Variety in fruit and vegetable consumption and the risk of lung cancer in the European prospective investigation into cancer and nutrition.
Cancer Epidemiol Biomarkers Prev 2010; 19(9):2278-86CE

Abstract

BACKGROUND

We investigated whether a varied consumption of vegetables and fruits is associated with lower lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study.

METHODS

After a mean follow-up of 8.7 years, 1,613 of 452,187 participants with complete information were diagnosed with lung cancer. Diet diversity scores (DDS) were used to quantify the variety in fruit and vegetable consumption. Multivariable proportional hazards models were used to assess the associations between DDS and lung cancer risk. All models were adjusted for smoking behavior and the total consumption of fruit and vegetables.

RESULTS

With increasing variety in vegetable subgroups, risk of lung cancer decreases [hazard ratios (HR), 0.77; 95% confidence interval (CI), 0.64-0.94 highest versus lowest quartile; P trend = 0.02]. This inverse association is restricted to current smokers (HR, 0.73; 95% CI, 0.57-0.93 highest versus lowest quartile; P trend = 0.03). In continuous analyses, in current smokers, lower risks were observed for squamous cell carcinomas with more variety in fruit and vegetable products combined (HR/two products, 0.88; 95% CI, 0.82-0.95), vegetable subgroups (HR/subgroup, 0.88; 95% CI, 0.79-0.97), vegetable products (HR/two products, 0.87; 95% CI, 0.79-0.96), and fruit products (HR/two products, 0.84; 95% CI, 0.72-0.97).

CONCLUSION

Variety in vegetable consumption was inversely associated with lung cancer risk among current smokers. Risk of squamous cell carcinomas was reduced with increasing variety in fruit and/or vegetable consumption, which was mainly driven by the effect in current smokers.

IMPACT

Independent from quantity of consumption, variety in fruit and vegetable consumption may decrease lung cancer risk.

Authors+Show Affiliations

National Institute ofPublicHealth and the Environment, Bilthoven, The Netherlands. frederike.buchner@rivm.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20807832

Citation

Büchner, Frederike L., et al. "Variety in Fruit and Vegetable Consumption and the Risk of Lung Cancer in the European Prospective Investigation Into Cancer and Nutrition." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 19, no. 9, 2010, pp. 2278-86.
Büchner FL, Bueno-de-Mesquita HB, Ros MM, et al. Variety in fruit and vegetable consumption and the risk of lung cancer in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev. 2010;19(9):2278-86.
Büchner, F. L., Bueno-de-Mesquita, H. B., Ros, M. M., Overvad, K., Dahm, C. C., Hansen, L., ... Riboli, E. (2010). Variety in fruit and vegetable consumption and the risk of lung cancer in the European prospective investigation into cancer and nutrition. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 19(9), pp. 2278-86. doi:10.1158/1055-9965.EPI-10-0489.
Büchner FL, et al. Variety in Fruit and Vegetable Consumption and the Risk of Lung Cancer in the European Prospective Investigation Into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev. 2010;19(9):2278-86. PubMed PMID: 20807832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variety in fruit and vegetable consumption and the risk of lung cancer in the European prospective investigation into cancer and nutrition. AU - Büchner,Frederike L, AU - Bueno-de-Mesquita,H Bas, AU - Ros,Martine M, AU - Overvad,Kim, AU - Dahm,Christina C, AU - Hansen,Louise, AU - Tjønneland,Anne, AU - Clavel-Chapelon,Françoise, AU - Boutron-Ruault,Marie-Christine, AU - Touillaud,Marina, AU - Kaaks,Rudolf, AU - Rohrmann,Sabine, AU - Boeing,Heiner, AU - Nöthlings,Ute, AU - Trichopoulou,Antonia, AU - Zylis,Dimosthenis, AU - Dilis,Vardis, AU - Palli,Domenico, AU - Sieri,Sabina, AU - Vineis,Paolo, AU - Tumino,Rosario, AU - Panico,Salvatore, AU - Peeters,Petra H M, AU - van Gils,Carla H, AU - Lund,Eiliv, AU - Gram,Inger T, AU - Braaten,Tonje, AU - Sánchez,María-José, AU - Agudo,Antonio, AU - Larrañaga,Nerea, AU - Ardanaz,Eva, AU - Navarro,Carmen, AU - Argüelles,Marcial V, AU - Manjer,Jonas, AU - Wirfält,Elisabet, AU - Hallmans,Göran, AU - Rasmuson,Torgny, AU - Key,Tim J, AU - Khaw,Kay-Tee, AU - Wareham,Nick, AU - Slimani,Nadia, AU - Vergnaud,Anne-Claire, AU - Xun,Wei W, AU - Kiemeney,Lambertus A L M, AU - Riboli,Elio, Y1 - 2010/08/31/ PY - 2010/9/3/entrez PY - 2010/9/3/pubmed PY - 2011/2/9/medline SP - 2278 EP - 86 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 19 IS - 9 N2 - BACKGROUND: We investigated whether a varied consumption of vegetables and fruits is associated with lower lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study. METHODS: After a mean follow-up of 8.7 years, 1,613 of 452,187 participants with complete information were diagnosed with lung cancer. Diet diversity scores (DDS) were used to quantify the variety in fruit and vegetable consumption. Multivariable proportional hazards models were used to assess the associations between DDS and lung cancer risk. All models were adjusted for smoking behavior and the total consumption of fruit and vegetables. RESULTS: With increasing variety in vegetable subgroups, risk of lung cancer decreases [hazard ratios (HR), 0.77; 95% confidence interval (CI), 0.64-0.94 highest versus lowest quartile; P trend = 0.02]. This inverse association is restricted to current smokers (HR, 0.73; 95% CI, 0.57-0.93 highest versus lowest quartile; P trend = 0.03). In continuous analyses, in current smokers, lower risks were observed for squamous cell carcinomas with more variety in fruit and vegetable products combined (HR/two products, 0.88; 95% CI, 0.82-0.95), vegetable subgroups (HR/subgroup, 0.88; 95% CI, 0.79-0.97), vegetable products (HR/two products, 0.87; 95% CI, 0.79-0.96), and fruit products (HR/two products, 0.84; 95% CI, 0.72-0.97). CONCLUSION: Variety in vegetable consumption was inversely associated with lung cancer risk among current smokers. Risk of squamous cell carcinomas was reduced with increasing variety in fruit and/or vegetable consumption, which was mainly driven by the effect in current smokers. IMPACT: Independent from quantity of consumption, variety in fruit and vegetable consumption may decrease lung cancer risk. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/20807832/Variety_in_fruit_and_vegetable_consumption_and_the_risk_of_lung_cancer_in_the_European_prospective_investigation_into_cancer_and_nutrition_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=20807832 DB - PRIME DP - Unbound Medicine ER -