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Physical activity and Alzheimer disease course.
Am J Geriatr Psychiatry 2011; 19(5):471-81AJ

Abstract

OBJECTIVES

To examine the association between physical activity (PA) and Alzheimer disease (AD) course.

BACKGROUND

PA has been related to lower risk for AD. Whether PA is associated with subsequent AD course has not been investigated.

METHODS

In a population-based study of individuals aged 65 years and older in New York who were prospectively followed up with standard neurologic and neuropsychological evaluations (every ~1.5 years), 357 participants i) were nondemented at baseline and ii) were diagnosed with AD during follow-up (incident AD). PA (sum of participation in a variety of physical activities, weighted by the type of activity [light, moderate, and severe]) obtained 2.4 (standard deviation [SD], 1.9) years before incidence was the main predictor of mortality in Cox models and of cognitive decline in generalized estimating equation models that were adjusted for age, gender, ethnicity, education, comorbidities, and duration between PA evaluation and dementia onset.

RESULTS

One hundred fifty incident AD cases (54%) died during the course of 5.2 (SD, 4.4) years of follow-up. When compared with incident AD cases who were physically inactive, those with some PA had lower mortality risk, whereas incident AD participants with much PA had an even lower risk. Additional adjustments for apolipoprotein genotype, smoking, comorbidity index, and cognitive performance did not change the associations. PA did not affect rates of cognitive or functional decline.

CONCLUSION

Exercise may affect not only risk for AD but also subsequent disease duration: more PA is associated with prolonged survival in AD.

Authors+Show Affiliations

Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, NY 10032, USA. ns257@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20808142

Citation

Scarmeas, Nikolaos, et al. "Physical Activity and Alzheimer Disease Course." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, vol. 19, no. 5, 2011, pp. 471-81.
Scarmeas N, Luchsinger JA, Brickman AM, et al. Physical activity and Alzheimer disease course. Am J Geriatr Psychiatry. 2011;19(5):471-81.
Scarmeas, N., Luchsinger, J. A., Brickman, A. M., Cosentino, S., Schupf, N., Xin-Tang, M., ... Stern, Y. (2011). Physical activity and Alzheimer disease course. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 19(5), pp. 471-81. doi:10.1097/JGP.0b013e3181eb00a9.
Scarmeas N, et al. Physical Activity and Alzheimer Disease Course. Am J Geriatr Psychiatry. 2011;19(5):471-81. PubMed PMID: 20808142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical activity and Alzheimer disease course. AU - Scarmeas,Nikolaos, AU - Luchsinger,Jose A, AU - Brickman,Adam M, AU - Cosentino,Stephanie, AU - Schupf,Nicole, AU - Xin-Tang,Ming, AU - Gu,Yian, AU - Stern,Yaakov, PY - 2010/9/3/entrez PY - 2010/9/3/pubmed PY - 2011/7/13/medline SP - 471 EP - 81 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry JO - Am J Geriatr Psychiatry VL - 19 IS - 5 N2 - OBJECTIVES: To examine the association between physical activity (PA) and Alzheimer disease (AD) course. BACKGROUND: PA has been related to lower risk for AD. Whether PA is associated with subsequent AD course has not been investigated. METHODS: In a population-based study of individuals aged 65 years and older in New York who were prospectively followed up with standard neurologic and neuropsychological evaluations (every ~1.5 years), 357 participants i) were nondemented at baseline and ii) were diagnosed with AD during follow-up (incident AD). PA (sum of participation in a variety of physical activities, weighted by the type of activity [light, moderate, and severe]) obtained 2.4 (standard deviation [SD], 1.9) years before incidence was the main predictor of mortality in Cox models and of cognitive decline in generalized estimating equation models that were adjusted for age, gender, ethnicity, education, comorbidities, and duration between PA evaluation and dementia onset. RESULTS: One hundred fifty incident AD cases (54%) died during the course of 5.2 (SD, 4.4) years of follow-up. When compared with incident AD cases who were physically inactive, those with some PA had lower mortality risk, whereas incident AD participants with much PA had an even lower risk. Additional adjustments for apolipoprotein genotype, smoking, comorbidity index, and cognitive performance did not change the associations. PA did not affect rates of cognitive or functional decline. CONCLUSION: Exercise may affect not only risk for AD but also subsequent disease duration: more PA is associated with prolonged survival in AD. SN - 1545-7214 UR - https://www.unboundmedicine.com/medline/citation/20808142/Physical_activity_and_Alzheimer_disease_course_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1064-7481(12)60051-7 DB - PRIME DP - Unbound Medicine ER -