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A cereal-based evening meal rich in indigestible carbohydrates increases plasma butyrate the next morning.
J Nutr 2010; 140(11):1932-6JN

Abstract

Epidemiological studies have shown an inverse relation between a whole grain consumption and risk of type-2 diabetes and cardiovascular disease. One tentative mechanism relates to colonic metabolism of indigestible carbohydrates. In a previous study, we reported a positive relation between colonic fermentation and improved glucose tolerance. This work can be seen as an extension of that study, focusing on the tentative role of specific colonic metabolites, i.e. SCFA. Plasma concentrations of acetate, propionate, and butyrate were determined in the morning in healthy participants (5 women and 10 men, mean ± SD: 25.9 ± 3.2 y, BMI < 25) following 8 different cereal-based evening meals (50 g available starch) varying in content of indigestible carbohydrates. Each participant consumed all test meals in a random order on separate evenings. At a standardized breakfast following evening test meals, the postprandial glucose response (incremental area under the curve, 0-120 min) was inversely related to plasma butyrate (r = -0.26; P < 0.01) and acetate (r = -0.20; P < 0.05) concentrations. Evening meals composed of high-amylose barley kernels or high-β-glucan barley kernels resulted in higher plasma butyrate concentrations the following morning compared with an evening meal with white wheat bread (P < 0.05). The results support the view that cereal products rich in indigestible carbohydrates may improve glucose tolerance through a mechanism involving colonic fermentation and generation of SCFA, where in particular butyric acid may be involved. This mechanism may be one explanation by which whole grain is protective against type 2 diabetes and cardiovascular disease.

Authors+Show Affiliations

Division of Applied Nutrition and Food Chemistry, Department of Food Technology, Engineering and Nutrition, Lund University, SE-22100 Lund, Sweden. anne.nilsson@appliednutrition.lth.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20810606

Citation

Nilsson, Anne C., et al. "A Cereal-based Evening Meal Rich in Indigestible Carbohydrates Increases Plasma Butyrate the Next Morning." The Journal of Nutrition, vol. 140, no. 11, 2010, pp. 1932-6.
Nilsson AC, Östman EM, Knudsen KE, et al. A cereal-based evening meal rich in indigestible carbohydrates increases plasma butyrate the next morning. J Nutr. 2010;140(11):1932-6.
Nilsson, A. C., Östman, E. M., Knudsen, K. E., Holst, J. J., & Björck, I. M. (2010). A cereal-based evening meal rich in indigestible carbohydrates increases plasma butyrate the next morning. The Journal of Nutrition, 140(11), pp. 1932-6. doi:10.3945/jn.110.123604.
Nilsson AC, et al. A Cereal-based Evening Meal Rich in Indigestible Carbohydrates Increases Plasma Butyrate the Next Morning. J Nutr. 2010;140(11):1932-6. PubMed PMID: 20810606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A cereal-based evening meal rich in indigestible carbohydrates increases plasma butyrate the next morning. AU - Nilsson,Anne C, AU - Östman,Elin M, AU - Knudsen,Knud Erik Bach, AU - Holst,Jens J, AU - Björck,Inger M E, Y1 - 2010/09/01/ PY - 2010/9/3/entrez PY - 2010/9/3/pubmed PY - 2010/11/10/medline SP - 1932 EP - 6 JF - The Journal of nutrition JO - J. Nutr. VL - 140 IS - 11 N2 - Epidemiological studies have shown an inverse relation between a whole grain consumption and risk of type-2 diabetes and cardiovascular disease. One tentative mechanism relates to colonic metabolism of indigestible carbohydrates. In a previous study, we reported a positive relation between colonic fermentation and improved glucose tolerance. This work can be seen as an extension of that study, focusing on the tentative role of specific colonic metabolites, i.e. SCFA. Plasma concentrations of acetate, propionate, and butyrate were determined in the morning in healthy participants (5 women and 10 men, mean ± SD: 25.9 ± 3.2 y, BMI < 25) following 8 different cereal-based evening meals (50 g available starch) varying in content of indigestible carbohydrates. Each participant consumed all test meals in a random order on separate evenings. At a standardized breakfast following evening test meals, the postprandial glucose response (incremental area under the curve, 0-120 min) was inversely related to plasma butyrate (r = -0.26; P < 0.01) and acetate (r = -0.20; P < 0.05) concentrations. Evening meals composed of high-amylose barley kernels or high-β-glucan barley kernels resulted in higher plasma butyrate concentrations the following morning compared with an evening meal with white wheat bread (P < 0.05). The results support the view that cereal products rich in indigestible carbohydrates may improve glucose tolerance through a mechanism involving colonic fermentation and generation of SCFA, where in particular butyric acid may be involved. This mechanism may be one explanation by which whole grain is protective against type 2 diabetes and cardiovascular disease. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/20810606/A_cereal_based_evening_meal_rich_in_indigestible_carbohydrates_increases_plasma_butyrate_the_next_morning_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.110.123604 DB - PRIME DP - Unbound Medicine ER -