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Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis.
Am J Clin Nutr 2010; 92(5):1189-96AJ

Abstract

BACKGROUND

The Mediterranean diet has long been reported to be protective against the occurrence of several different health outcomes.

OBJECTIVE

We aimed to update our previous meta-analysis of published cohort prospective studies that investigated the effects of adherence to the Mediterranean diet on health status.

DESIGN

We conducted a comprehensive literature search through electronic databases up to June 2010.

RESULTS

The updated review process showed 7 prospective studies published in the past 2 y that were not included in the previous meta-analysis (1 study for overall mortality, 3 studies for cardiovascular incidence or mortality, 1 study for cancer incidence or mortality, and 2 studies for neurodegenerative diseases). These recent studies included 2 health outcomes not previously investigated (ie, mild cognitive impairment and stroke). The meta-analysis for all studies with a random-effects model that was conducted after the inclusion of these recent studies showed that a 2-point increase in adherence to the Mediterranean diet was associated with a significant reduction of overall mortality [relative risk (RR) = 0.92; 95% CI: 0.90, 0.94], cardiovascular incidence or mortality (RR = 0.90; 95% CI: 0.87, 0.93), cancer incidence or mortality (RR = 0.94; 95% CI: 0.92, 0.96), and neurodegenerative diseases (RR = 0.87; 95% CI: 0.81, 0.94). The meta-regression analysis showed that sample size was the most significant contributor to the model because it significantly influenced the estimate of the association for overall mortality.

CONCLUSION

This updated meta-analysis confirms, in a larger number of subjects and studies, the significant and consistent protection provided by adherence to the Mediterranean diet in relation to the occurrence of major chronic degenerative diseases.

Authors+Show Affiliations

Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy. francescosofi@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

20810976

Citation

Sofi, Francesco, et al. "Accruing Evidence On Benefits of Adherence to the Mediterranean Diet On Health: an Updated Systematic Review and Meta-analysis." The American Journal of Clinical Nutrition, vol. 92, no. 5, 2010, pp. 1189-96.
Sofi F, Abbate R, Gensini GF, et al. Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am J Clin Nutr. 2010;92(5):1189-96.
Sofi, F., Abbate, R., Gensini, G. F., & Casini, A. (2010). Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. The American Journal of Clinical Nutrition, 92(5), pp. 1189-96. doi:10.3945/ajcn.2010.29673.
Sofi F, et al. Accruing Evidence On Benefits of Adherence to the Mediterranean Diet On Health: an Updated Systematic Review and Meta-analysis. Am J Clin Nutr. 2010;92(5):1189-96. PubMed PMID: 20810976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. AU - Sofi,Francesco, AU - Abbate,Rosanna, AU - Gensini,Gian Franco, AU - Casini,Alessandro, Y1 - 2010/09/01/ PY - 2010/9/3/entrez PY - 2010/9/3/pubmed PY - 2010/11/10/medline SP - 1189 EP - 96 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 92 IS - 5 N2 - BACKGROUND: The Mediterranean diet has long been reported to be protective against the occurrence of several different health outcomes. OBJECTIVE: We aimed to update our previous meta-analysis of published cohort prospective studies that investigated the effects of adherence to the Mediterranean diet on health status. DESIGN: We conducted a comprehensive literature search through electronic databases up to June 2010. RESULTS: The updated review process showed 7 prospective studies published in the past 2 y that were not included in the previous meta-analysis (1 study for overall mortality, 3 studies for cardiovascular incidence or mortality, 1 study for cancer incidence or mortality, and 2 studies for neurodegenerative diseases). These recent studies included 2 health outcomes not previously investigated (ie, mild cognitive impairment and stroke). The meta-analysis for all studies with a random-effects model that was conducted after the inclusion of these recent studies showed that a 2-point increase in adherence to the Mediterranean diet was associated with a significant reduction of overall mortality [relative risk (RR) = 0.92; 95% CI: 0.90, 0.94], cardiovascular incidence or mortality (RR = 0.90; 95% CI: 0.87, 0.93), cancer incidence or mortality (RR = 0.94; 95% CI: 0.92, 0.96), and neurodegenerative diseases (RR = 0.87; 95% CI: 0.81, 0.94). The meta-regression analysis showed that sample size was the most significant contributor to the model because it significantly influenced the estimate of the association for overall mortality. CONCLUSION: This updated meta-analysis confirms, in a larger number of subjects and studies, the significant and consistent protection provided by adherence to the Mediterranean diet in relation to the occurrence of major chronic degenerative diseases. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20810976/Accruing_evidence_on_benefits_of_adherence_to_the_Mediterranean_diet_on_health:_an_updated_systematic_review_and_meta_analysis_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2010.29673 DB - PRIME DP - Unbound Medicine ER -