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The effect of pregabalin on pain-related sleep interference in diabetic peripheral neuropathy or postherpetic neuralgia: a review of nine clinical trials.
Curr Med Res Opin. 2010 Oct; 26(10):2411-9.CM

Abstract

OBJECTIVE

Postherpetic neuralgia and painful diabetic peripheral neuropathy are common chronic neuropathic pain conditions associated with sleep disturbances. Pregabalin is indicated in the treatment of neuropathic pain. The objective of this review is to summarize the efficacy and safety of pregabalin in painful diabetic peripheral neuropathy and postherpetic neuralgia and the effect of pregabalin on sleep interference in these patients.

METHODS

MEDLINE and ISI Web of Knowledge databases were searched for randomized double-blind, placebo-controlled clinical trials of pregabalin reporting sleep measures in addition to pain endpoints in patients with painful diabetic peripheral neuropathy and postherpetic neuralgia published from inception through March 2009.

RESULTS

Nine trials met the inclusion criteria, providing data for a total of 2399 patients with painful diabetic peripheral neuropathy or postherpetic neuralgia treated twice or three times per day with pregabalin (75-600 mg/day) or placebo on a fixed or flexible schedule. Interpretation of sleep outcomes in two studies may be limited by trial inclusion criteria which permitted benzodiazepines for sleep problems. Also, none of the studies reported objective sleep measures. Pregabalin was well tolerated. Pregabalin (150-600 mg/day) significantly reduced pain and improved pain-related sleep interference.

CONCLUSIONS

In addition to an analgesic benefit, pregabalin may decrease pain-related sleep interference in patients with painful diabetic peripheral neuropathy and postherpetic neuralgia.

Authors+Show Affiliations

Division of Sleep Medicine and Research Center, Henry Ford Health System, Detroit, MI 48202, USA. troth1@hfhs.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20812792

Citation

Roth, Thomas, et al. "The Effect of Pregabalin On Pain-related Sleep Interference in Diabetic Peripheral Neuropathy or Postherpetic Neuralgia: a Review of Nine Clinical Trials." Current Medical Research and Opinion, vol. 26, no. 10, 2010, pp. 2411-9.
Roth T, van Seventer R, Murphy TK. The effect of pregabalin on pain-related sleep interference in diabetic peripheral neuropathy or postherpetic neuralgia: a review of nine clinical trials. Curr Med Res Opin. 2010;26(10):2411-9.
Roth, T., van Seventer, R., & Murphy, T. K. (2010). The effect of pregabalin on pain-related sleep interference in diabetic peripheral neuropathy or postherpetic neuralgia: a review of nine clinical trials. Current Medical Research and Opinion, 26(10), 2411-9. https://doi.org/10.1185/03007995.2010.516142
Roth T, van Seventer R, Murphy TK. The Effect of Pregabalin On Pain-related Sleep Interference in Diabetic Peripheral Neuropathy or Postherpetic Neuralgia: a Review of Nine Clinical Trials. Curr Med Res Opin. 2010;26(10):2411-9. PubMed PMID: 20812792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of pregabalin on pain-related sleep interference in diabetic peripheral neuropathy or postherpetic neuralgia: a review of nine clinical trials. AU - Roth,Thomas, AU - van Seventer,Robert, AU - Murphy,T Kevin, PY - 2010/9/4/entrez PY - 2010/9/4/pubmed PY - 2011/2/10/medline SP - 2411 EP - 9 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 26 IS - 10 N2 - OBJECTIVE: Postherpetic neuralgia and painful diabetic peripheral neuropathy are common chronic neuropathic pain conditions associated with sleep disturbances. Pregabalin is indicated in the treatment of neuropathic pain. The objective of this review is to summarize the efficacy and safety of pregabalin in painful diabetic peripheral neuropathy and postherpetic neuralgia and the effect of pregabalin on sleep interference in these patients. METHODS: MEDLINE and ISI Web of Knowledge databases were searched for randomized double-blind, placebo-controlled clinical trials of pregabalin reporting sleep measures in addition to pain endpoints in patients with painful diabetic peripheral neuropathy and postherpetic neuralgia published from inception through March 2009. RESULTS: Nine trials met the inclusion criteria, providing data for a total of 2399 patients with painful diabetic peripheral neuropathy or postherpetic neuralgia treated twice or three times per day with pregabalin (75-600 mg/day) or placebo on a fixed or flexible schedule. Interpretation of sleep outcomes in two studies may be limited by trial inclusion criteria which permitted benzodiazepines for sleep problems. Also, none of the studies reported objective sleep measures. Pregabalin was well tolerated. Pregabalin (150-600 mg/day) significantly reduced pain and improved pain-related sleep interference. CONCLUSIONS: In addition to an analgesic benefit, pregabalin may decrease pain-related sleep interference in patients with painful diabetic peripheral neuropathy and postherpetic neuralgia. SN - 1473-4877 UR - https://www.unboundmedicine.com/medline/citation/20812792/The_effect_of_pregabalin_on_pain_related_sleep_interference_in_diabetic_peripheral_neuropathy_or_postherpetic_neuralgia:_a_review_of_nine_clinical_trials_ L2 - https://www.tandfonline.com/doi/full/10.1185/03007995.2010.516142 DB - PRIME DP - Unbound Medicine ER -