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Alcoholic beverages and prostate cancer in a prospective US cohort study.

Abstract

Despite numerous investigations, the correlation between alcohol consumption and prostate cancer risk remains uncertain. This report investigated the association between alcohol use and prostate cancer risk in a prospective cohort study of 294,707 US men aged 50-71 years in 1995-1996. Cox proportional hazards regression models with hazard ratios and 95% confidence intervals were adjusted for characteristics including age, race, body mass index, physical activity, and family history of prostate cancer, as well as testing for prostate-specific antigen and a digital rectal examination. There were 15,327 nonadvanced and 1,900 advanced prostate cancers identified through 2003 and 514 fatal cases through 2005. Risk of nonadvanced prostate cancer was 25% higher for men consuming ≥6 drinks daily (hazard ratio = 1.25, 95% confidence interval: 1.13, 1.37), 19% higher for men consuming 3-<6 drinks daily, and 6% higher for men consuming up to 3 drinks daily, compared with nondrinkers. The association between alcohol consumption and nonadvanced prostate cancer risk did not differ appreciably by age, family history of prostate cancer, smoking status, body mass index, or self-reported prostate-specific antigen testing and digital rectal examination (the latter available for >60% of respondents). The authors observed no association between alcohol intake and advanced prostate cancer and an inverse association with fatal prostate cancer among heavy drinkers. These findings suggest that higher alcohol consumption modestly increases nonadvanced prostate cancer risk.

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  • Authors+Show Affiliations

    ,

    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. wattersj@mail.nih.gov

    , , ,

    Source

    American journal of epidemiology 172:7 2010 Oct 01 pg 773-80

    MeSH

    Age Distribution
    Aged
    Alcohol Drinking
    Alcoholic Beverages
    Confidence Intervals
    Follow-Up Studies
    Humans
    Incidence
    Male
    Middle Aged
    Prognosis
    Proportional Hazards Models
    Prospective Studies
    Prostate-Specific Antigen
    Prostatic Neoplasms
    Risk Factors
    Survival Rate
    United States

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    20813803

    Citation

    Watters, Joanne L., et al. "Alcoholic Beverages and Prostate Cancer in a Prospective US Cohort Study." American Journal of Epidemiology, vol. 172, no. 7, 2010, pp. 773-80.
    Watters JL, Park Y, Hollenbeck A, et al. Alcoholic beverages and prostate cancer in a prospective US cohort study. Am J Epidemiol. 2010;172(7):773-80.
    Watters, J. L., Park, Y., Hollenbeck, A., Schatzkin, A., & Albanes, D. (2010). Alcoholic beverages and prostate cancer in a prospective US cohort study. American Journal of Epidemiology, 172(7), pp. 773-80. doi:10.1093/aje/kwq200.
    Watters JL, et al. Alcoholic Beverages and Prostate Cancer in a Prospective US Cohort Study. Am J Epidemiol. 2010 Oct 1;172(7):773-80. PubMed PMID: 20813803.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcoholic beverages and prostate cancer in a prospective US cohort study. AU - Watters,Joanne L, AU - Park,Yikyung, AU - Hollenbeck,Albert, AU - Schatzkin,Arthur, AU - Albanes,Demetrius, Y1 - 2010/09/02/ PY - 2010/9/4/entrez PY - 2010/9/4/pubmed PY - 2010/10/13/medline SP - 773 EP - 80 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 172 IS - 7 N2 - Despite numerous investigations, the correlation between alcohol consumption and prostate cancer risk remains uncertain. This report investigated the association between alcohol use and prostate cancer risk in a prospective cohort study of 294,707 US men aged 50-71 years in 1995-1996. Cox proportional hazards regression models with hazard ratios and 95% confidence intervals were adjusted for characteristics including age, race, body mass index, physical activity, and family history of prostate cancer, as well as testing for prostate-specific antigen and a digital rectal examination. There were 15,327 nonadvanced and 1,900 advanced prostate cancers identified through 2003 and 514 fatal cases through 2005. Risk of nonadvanced prostate cancer was 25% higher for men consuming ≥6 drinks daily (hazard ratio = 1.25, 95% confidence interval: 1.13, 1.37), 19% higher for men consuming 3-<6 drinks daily, and 6% higher for men consuming up to 3 drinks daily, compared with nondrinkers. The association between alcohol consumption and nonadvanced prostate cancer risk did not differ appreciably by age, family history of prostate cancer, smoking status, body mass index, or self-reported prostate-specific antigen testing and digital rectal examination (the latter available for >60% of respondents). The authors observed no association between alcohol intake and advanced prostate cancer and an inverse association with fatal prostate cancer among heavy drinkers. These findings suggest that higher alcohol consumption modestly increases nonadvanced prostate cancer risk. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/20813803/Alcoholic_beverages_and_prostate_cancer_in_a_prospective_US_cohort_study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwq200 DB - PRIME DP - Unbound Medicine ER -