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Alcoholic beverages and prostate cancer in a prospective US cohort study.
Am J Epidemiol 2010; 172(7):773-80AJ

Abstract

Despite numerous investigations, the correlation between alcohol consumption and prostate cancer risk remains uncertain. This report investigated the association between alcohol use and prostate cancer risk in a prospective cohort study of 294,707 US men aged 50-71 years in 1995-1996. Cox proportional hazards regression models with hazard ratios and 95% confidence intervals were adjusted for characteristics including age, race, body mass index, physical activity, and family history of prostate cancer, as well as testing for prostate-specific antigen and a digital rectal examination. There were 15,327 nonadvanced and 1,900 advanced prostate cancers identified through 2003 and 514 fatal cases through 2005. Risk of nonadvanced prostate cancer was 25% higher for men consuming ≥6 drinks daily (hazard ratio = 1.25, 95% confidence interval: 1.13, 1.37), 19% higher for men consuming 3-<6 drinks daily, and 6% higher for men consuming up to 3 drinks daily, compared with nondrinkers. The association between alcohol consumption and nonadvanced prostate cancer risk did not differ appreciably by age, family history of prostate cancer, smoking status, body mass index, or self-reported prostate-specific antigen testing and digital rectal examination (the latter available for >60% of respondents). The authors observed no association between alcohol intake and advanced prostate cancer and an inverse association with fatal prostate cancer among heavy drinkers. These findings suggest that higher alcohol consumption modestly increases nonadvanced prostate cancer risk.

Authors+Show Affiliations

Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. wattersj@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

20813803

Citation

Watters, Joanne L., et al. "Alcoholic Beverages and Prostate Cancer in a Prospective US Cohort Study." American Journal of Epidemiology, vol. 172, no. 7, 2010, pp. 773-80.
Watters JL, Park Y, Hollenbeck A, et al. Alcoholic beverages and prostate cancer in a prospective US cohort study. Am J Epidemiol. 2010;172(7):773-80.
Watters, J. L., Park, Y., Hollenbeck, A., Schatzkin, A., & Albanes, D. (2010). Alcoholic beverages and prostate cancer in a prospective US cohort study. American Journal of Epidemiology, 172(7), pp. 773-80. doi:10.1093/aje/kwq200.
Watters JL, et al. Alcoholic Beverages and Prostate Cancer in a Prospective US Cohort Study. Am J Epidemiol. 2010 Oct 1;172(7):773-80. PubMed PMID: 20813803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcoholic beverages and prostate cancer in a prospective US cohort study. AU - Watters,Joanne L, AU - Park,Yikyung, AU - Hollenbeck,Albert, AU - Schatzkin,Arthur, AU - Albanes,Demetrius, Y1 - 2010/09/02/ PY - 2010/9/4/entrez PY - 2010/9/4/pubmed PY - 2010/10/13/medline SP - 773 EP - 80 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 172 IS - 7 N2 - Despite numerous investigations, the correlation between alcohol consumption and prostate cancer risk remains uncertain. This report investigated the association between alcohol use and prostate cancer risk in a prospective cohort study of 294,707 US men aged 50-71 years in 1995-1996. Cox proportional hazards regression models with hazard ratios and 95% confidence intervals were adjusted for characteristics including age, race, body mass index, physical activity, and family history of prostate cancer, as well as testing for prostate-specific antigen and a digital rectal examination. There were 15,327 nonadvanced and 1,900 advanced prostate cancers identified through 2003 and 514 fatal cases through 2005. Risk of nonadvanced prostate cancer was 25% higher for men consuming ≥6 drinks daily (hazard ratio = 1.25, 95% confidence interval: 1.13, 1.37), 19% higher for men consuming 3-<6 drinks daily, and 6% higher for men consuming up to 3 drinks daily, compared with nondrinkers. The association between alcohol consumption and nonadvanced prostate cancer risk did not differ appreciably by age, family history of prostate cancer, smoking status, body mass index, or self-reported prostate-specific antigen testing and digital rectal examination (the latter available for >60% of respondents). The authors observed no association between alcohol intake and advanced prostate cancer and an inverse association with fatal prostate cancer among heavy drinkers. These findings suggest that higher alcohol consumption modestly increases nonadvanced prostate cancer risk. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/20813803/Alcoholic_beverages_and_prostate_cancer_in_a_prospective_US_cohort_study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwq200 DB - PRIME DP - Unbound Medicine ER -