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Common carotid intima-media thickness and framingham risk score predict incident carotid atherosclerotic plaque formation: longitudinal results from the study of health in Pomerania.
Stroke 2010; 41(10):2375-7S

Abstract

BACKGROUND AND PURPOSE

Cross-sectional studies describe a positive association between common carotid artery intima-media thickness (CCA-IMT) and carotid plaques (CP). However, longitudinal data on the predictive value of CCA-IMT for occurrence of CP are limited. Therefore, the role of increasing CCA-IMT in the atherosclerotic process is still discussed controversially.

METHODS

We investigated the predictive value of CCA-IMT and the Framingham risk score (FRS) for incident CP formation in a population-based longitudinal study of 1922 subjects aged 45 to 81 years who underwent ultrasonography of both carotid arteries and received vascular risk factor assessment at baseline and after 5 years. CP was defined as any protruding focal thickening of the intima-media complex. Incident CP formation during follow-up was defined as the appearance of at least 1 CP in a previously plaque-free arterial segment (right and left common, internal, and external carotid arteries and carotid bifurcation).

RESULTS

Among the 636 subjects without CP at baseline, 418 (66%) had at least 1 incident CP during follow-up. In a multivariable negative binominal regression model adjusted for age, gender, and the FRS, the number of arterial segments affected by incident CP was 1.53-fold higher (CI, 1.12-2.07; P<0.01) for subjects in the highest quartile of the overall CCA-IMT distribution compared to those in the lowest quartile.

CONCLUSIONS

Both CCA-IMT and FRS independently predict incident CP formation. The risk of CP formation may actually be underestimated in subjects with low FRS and high IMT.

Authors+Show Affiliations

Department of Neurology, Institute for Community Medicine, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany. Bettina.vonSarnowski@uni-greifswald.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20814002

Citation

von Sarnowski, Bettina, et al. "Common Carotid Intima-media Thickness and Framingham Risk Score Predict Incident Carotid Atherosclerotic Plaque Formation: Longitudinal Results From the Study of Health in Pomerania." Stroke, vol. 41, no. 10, 2010, pp. 2375-7.
von Sarnowski B, Lüdemann J, Völzke H, et al. Common carotid intima-media thickness and framingham risk score predict incident carotid atherosclerotic plaque formation: longitudinal results from the study of health in Pomerania. Stroke. 2010;41(10):2375-7.
von Sarnowski, B., Lüdemann, J., Völzke, H., Dörr, M., Kessler, C., & Schminke, U. (2010). Common carotid intima-media thickness and framingham risk score predict incident carotid atherosclerotic plaque formation: longitudinal results from the study of health in Pomerania. Stroke, 41(10), pp. 2375-7. doi:10.1161/STROKEAHA.110.593244.
von Sarnowski B, et al. Common Carotid Intima-media Thickness and Framingham Risk Score Predict Incident Carotid Atherosclerotic Plaque Formation: Longitudinal Results From the Study of Health in Pomerania. Stroke. 2010;41(10):2375-7. PubMed PMID: 20814002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Common carotid intima-media thickness and framingham risk score predict incident carotid atherosclerotic plaque formation: longitudinal results from the study of health in Pomerania. AU - von Sarnowski,Bettina, AU - Lüdemann,Jan, AU - Völzke,Henry, AU - Dörr,Marcus, AU - Kessler,Christof, AU - Schminke,Ulf, Y1 - 2010/09/02/ PY - 2010/9/4/entrez PY - 2010/9/4/pubmed PY - 2010/10/20/medline SP - 2375 EP - 7 JF - Stroke JO - Stroke VL - 41 IS - 10 N2 - BACKGROUND AND PURPOSE: Cross-sectional studies describe a positive association between common carotid artery intima-media thickness (CCA-IMT) and carotid plaques (CP). However, longitudinal data on the predictive value of CCA-IMT for occurrence of CP are limited. Therefore, the role of increasing CCA-IMT in the atherosclerotic process is still discussed controversially. METHODS: We investigated the predictive value of CCA-IMT and the Framingham risk score (FRS) for incident CP formation in a population-based longitudinal study of 1922 subjects aged 45 to 81 years who underwent ultrasonography of both carotid arteries and received vascular risk factor assessment at baseline and after 5 years. CP was defined as any protruding focal thickening of the intima-media complex. Incident CP formation during follow-up was defined as the appearance of at least 1 CP in a previously plaque-free arterial segment (right and left common, internal, and external carotid arteries and carotid bifurcation). RESULTS: Among the 636 subjects without CP at baseline, 418 (66%) had at least 1 incident CP during follow-up. In a multivariable negative binominal regression model adjusted for age, gender, and the FRS, the number of arterial segments affected by incident CP was 1.53-fold higher (CI, 1.12-2.07; P<0.01) for subjects in the highest quartile of the overall CCA-IMT distribution compared to those in the lowest quartile. CONCLUSIONS: Both CCA-IMT and FRS independently predict incident CP formation. The risk of CP formation may actually be underestimated in subjects with low FRS and high IMT. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/20814002/Common_carotid_intima_media_thickness_and_framingham_risk_score_predict_incident_carotid_atherosclerotic_plaque_formation:_longitudinal_results_from_the_study_of_health_in_Pomerania_ L2 - http://www.ahajournals.org/doi/full/10.1161/STROKEAHA.110.593244?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -