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Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves.
Pharm Biol. 2010 Oct; 48(10):1130-6.PB

Abstract

CONTEXT

Cinnamomum osmophloeum Kaneh. (Lauraceae) is one of the indigenous tree species in Taiwan. This tree species has been of interest to researchers because the chemical constituents of its essential oil are similar to those of Cinnamomum cassia Presl. bark oil, known as cinnamon oil, which is commonly used in foods and beverages.

OBJECTIVE

The anti-inflammatory activities of the leaf essential oils and their major compounds from seven provenances of C. osmophloeum are investigated here for the first time.

MATERIALS AND METHODS

Chemical compositions of hydrodistilled essential oils obtained from C. osmophloeum leaves were analyzed by gas chromatography-mass spectrometry (GC-MS), and the effects of essential oils on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages were investigated.

RESULTS

The leaf essential oils of cinnamaldehyde type and mixed type strongly inhibited NO production, with IC(50) values ranging from 9.7-15.5 μg/mL. Furthermore, trans-cinnamaldehyde is responsible for the inhibitory activity of cinnamaldehyde type, and T-cadinol and α-cadinol are responsible for the inhibitory activity of mixed type.

DISCUSSION AND CONCLUSION

These findings demonstrate that the leaf essential oils and their constituents of C. osmophloeum have excellent anti-inflammatory activities and thus have great potential as a source for natural health products.

Authors+Show Affiliations

School of Forestry and Resource Conservation, National Taiwan University, Taipei 106, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20815702

Citation

Tung, Yu-Tang, et al. "Anti-inflammatory Activities of Essential Oils and Their Constituents From Different Provenances of Indigenous Cinnamon (Cinnamomum Osmophloeum) Leaves." Pharmaceutical Biology, vol. 48, no. 10, 2010, pp. 1130-6.
Tung YT, Yen PL, Lin CY, et al. Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves. Pharm Biol. 2010;48(10):1130-6.
Tung, Y. T., Yen, P. L., Lin, C. Y., & Chang, S. T. (2010). Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves. Pharmaceutical Biology, 48(10), 1130-6. https://doi.org/10.3109/13880200903527728
Tung YT, et al. Anti-inflammatory Activities of Essential Oils and Their Constituents From Different Provenances of Indigenous Cinnamon (Cinnamomum Osmophloeum) Leaves. Pharm Biol. 2010;48(10):1130-6. PubMed PMID: 20815702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves. AU - Tung,Yu-Tang, AU - Yen,Pei-Ling, AU - Lin,Chun-Ya, AU - Chang,Shang-Tzen, PY - 2010/9/7/entrez PY - 2010/9/8/pubmed PY - 2011/1/28/medline SP - 1130 EP - 6 JF - Pharmaceutical biology JO - Pharm Biol VL - 48 IS - 10 N2 - CONTEXT: Cinnamomum osmophloeum Kaneh. (Lauraceae) is one of the indigenous tree species in Taiwan. This tree species has been of interest to researchers because the chemical constituents of its essential oil are similar to those of Cinnamomum cassia Presl. bark oil, known as cinnamon oil, which is commonly used in foods and beverages. OBJECTIVE: The anti-inflammatory activities of the leaf essential oils and their major compounds from seven provenances of C. osmophloeum are investigated here for the first time. MATERIALS AND METHODS: Chemical compositions of hydrodistilled essential oils obtained from C. osmophloeum leaves were analyzed by gas chromatography-mass spectrometry (GC-MS), and the effects of essential oils on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages were investigated. RESULTS: The leaf essential oils of cinnamaldehyde type and mixed type strongly inhibited NO production, with IC(50) values ranging from 9.7-15.5 μg/mL. Furthermore, trans-cinnamaldehyde is responsible for the inhibitory activity of cinnamaldehyde type, and T-cadinol and α-cadinol are responsible for the inhibitory activity of mixed type. DISCUSSION AND CONCLUSION: These findings demonstrate that the leaf essential oils and their constituents of C. osmophloeum have excellent anti-inflammatory activities and thus have great potential as a source for natural health products. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/20815702/Anti_inflammatory_activities_of_essential_oils_and_their_constituents_from_different_provenances_of_indigenous_cinnamon__Cinnamomum_osmophloeum__leaves_ DB - PRIME DP - Unbound Medicine ER -