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Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease.
Free Radic Res. 2011 Jan; 45(1):73-88.FR

Abstract

The free radical theory of ageing proposes the accumulation of altered, less active and toxic molecules of DNA, RNA, proteins and lipids caused by reactive oxygen species and reactive nitrogen species. Neurodegenerative disorders are characterized by an abnormal accumulation of oxidatively damaged macromolecules inside cells and in the extracellular space. Proteins involved in the formation of aggregates are β-amyloid, tau, α-synuclein, parkin, prion proteins and proteins containing polyglutamine. These abnormal aggregated proteins influence normal cellular metabolism. Additionally, deposition of abnormal proteins induces oxidative stress and proteasomal as well as mitochondrial dysfunction that ultimately lead to neuronal cell death. This review focuses on the impact of oxidative and nitrative stress in the ageing brain and, consequently, on the generation of modified proteins, as these post-translational modifications are assumed to play an important role in the development of neurodegenerative diseases.

Authors+Show Affiliations

Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straβe 24, 07743 Jena, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20815785

Citation

Grimm, Stefanie, et al. "Protein Oxidative Modifications in the Ageing Brain: Consequence for the Onset of Neurodegenerative Disease." Free Radical Research, vol. 45, no. 1, 2011, pp. 73-88.
Grimm S, Hoehn A, Davies KJ, et al. Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease. Free Radic Res. 2011;45(1):73-88.
Grimm, S., Hoehn, A., Davies, K. J., & Grune, T. (2011). Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease. Free Radical Research, 45(1), 73-88. https://doi.org/10.3109/10715762.2010.512040
Grimm S, et al. Protein Oxidative Modifications in the Ageing Brain: Consequence for the Onset of Neurodegenerative Disease. Free Radic Res. 2011;45(1):73-88. PubMed PMID: 20815785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease. AU - Grimm,Stefanie, AU - Hoehn,Annika, AU - Davies,Kelvin J, AU - Grune,Tilman, Y1 - 2010/09/06/ PY - 2010/9/7/entrez PY - 2010/9/8/pubmed PY - 2011/5/21/medline SP - 73 EP - 88 JF - Free radical research JO - Free Radic. Res. VL - 45 IS - 1 N2 - The free radical theory of ageing proposes the accumulation of altered, less active and toxic molecules of DNA, RNA, proteins and lipids caused by reactive oxygen species and reactive nitrogen species. Neurodegenerative disorders are characterized by an abnormal accumulation of oxidatively damaged macromolecules inside cells and in the extracellular space. Proteins involved in the formation of aggregates are β-amyloid, tau, α-synuclein, parkin, prion proteins and proteins containing polyglutamine. These abnormal aggregated proteins influence normal cellular metabolism. Additionally, deposition of abnormal proteins induces oxidative stress and proteasomal as well as mitochondrial dysfunction that ultimately lead to neuronal cell death. This review focuses on the impact of oxidative and nitrative stress in the ageing brain and, consequently, on the generation of modified proteins, as these post-translational modifications are assumed to play an important role in the development of neurodegenerative diseases. SN - 1029-2470 UR - https://www.unboundmedicine.com/medline/citation/20815785/Protein_oxidative_modifications_in_the_ageing_brain:_consequence_for_the_onset_of_neurodegenerative_disease_ L2 - http://www.tandfonline.com/doi/full/10.3109/10715762.2010.512040 DB - PRIME DP - Unbound Medicine ER -