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Intestinal ferritin H is required for an accurate control of iron absorption.
Cell Metab. 2010 Sep 08; 12(3):273-82.CM

Abstract

To maintain appropriate body iron levels, iron absorption by the proximal duodenum is thought to be controlled by hepcidin, a polypeptide secreted by hepatocytes in response to high serum iron. Hepcidin limits basolateral iron efflux from the duodenal epithelium by binding and downregulating the intestinal iron exporter ferroportin. Here, we found that mice with an intestinal ferritin H gene deletion show increased body iron stores and transferrin saturation. As expected for iron-loaded animals, the ferritin H-deleted mice showed induced liver hepcidin mRNA levels and reduced duodenal expression of DMT1 and DcytB mRNA. In spite of these feedback controls, intestinal ferroportin protein and (59)Fe absorption were increased more than 2-fold in the deleted mice. Our results demonstrate that hepcidin-mediated regulation alone is insufficient to restrict iron absorption and that intestinal ferritin H is also required to limit iron efflux from intestinal cells.

Authors+Show Affiliations

ISREC - Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20816093

Citation

Vanoaica, Liviu, et al. "Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption." Cell Metabolism, vol. 12, no. 3, 2010, pp. 273-82.
Vanoaica L, Darshan D, Richman L, et al. Intestinal ferritin H is required for an accurate control of iron absorption. Cell Metab. 2010;12(3):273-82.
Vanoaica, L., Darshan, D., Richman, L., Schümann, K., & Kühn, L. C. (2010). Intestinal ferritin H is required for an accurate control of iron absorption. Cell Metabolism, 12(3), 273-82. https://doi.org/10.1016/j.cmet.2010.08.003
Vanoaica L, et al. Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption. Cell Metab. 2010 Sep 8;12(3):273-82. PubMed PMID: 20816093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal ferritin H is required for an accurate control of iron absorption. AU - Vanoaica,Liviu, AU - Darshan,Deepak, AU - Richman,Larry, AU - Schümann,Klaus, AU - Kühn,Lukas C, PY - 2010/02/08/received PY - 2010/05/08/revised PY - 2010/06/16/accepted PY - 2010/9/7/entrez PY - 2010/9/8/pubmed PY - 2010/11/5/medline SP - 273 EP - 82 JF - Cell metabolism JO - Cell Metab VL - 12 IS - 3 N2 - To maintain appropriate body iron levels, iron absorption by the proximal duodenum is thought to be controlled by hepcidin, a polypeptide secreted by hepatocytes in response to high serum iron. Hepcidin limits basolateral iron efflux from the duodenal epithelium by binding and downregulating the intestinal iron exporter ferroportin. Here, we found that mice with an intestinal ferritin H gene deletion show increased body iron stores and transferrin saturation. As expected for iron-loaded animals, the ferritin H-deleted mice showed induced liver hepcidin mRNA levels and reduced duodenal expression of DMT1 and DcytB mRNA. In spite of these feedback controls, intestinal ferroportin protein and (59)Fe absorption were increased more than 2-fold in the deleted mice. Our results demonstrate that hepcidin-mediated regulation alone is insufficient to restrict iron absorption and that intestinal ferritin H is also required to limit iron efflux from intestinal cells. SN - 1932-7420 UR - https://www.unboundmedicine.com/medline/citation/20816093/Intestinal_ferritin_H_is_required_for_an_accurate_control_of_iron_absorption_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1550-4131(10)00268-8 DB - PRIME DP - Unbound Medicine ER -